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6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE

6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE Struktur
49843-98-3
CAS-Nr.
49843-98-3
Englisch Name:
6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE
Synonyma:
Selisistat;EX 527 (SEN0014196);SIRT1 Inhibitor III;CS-1862;Selisista;SEN0014196;(S)-EX-527;EX 527, >=98%;EX 527; EX527;Selisistat - EX 527
CBNumber:
CB6230650
Summenformel:
C13H13ClN2O
Molgewicht:
248.71
MOL-Datei:
49843-98-3.mol

6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE Eigenschaften

Schmelzpunkt:
179.0 to 183.0 °C
Siedepunkt:
531.7±38.0 °C(Predicted)
Dichte
1.388
storage temp. 
2-8°C
L?slichkeit
Soluble in dimethyl sulfoxide, ethanol and dimethyl formamide.
Aggregatzustand
powder
pka
16.12±0.40(Predicted)
Farbe
white to beige
Stabilit?t:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 22-36
S-S?tze: 26
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
HS Code  2933998090
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizit?t oral Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P264, P270, P301+P310, P321, P330,P405, P501
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P337+P313 Bei anhaltender Augenreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

A selective inhibitor of SIRT1 over SIRT2 and SIRT3

Allgemeine Beschreibung

A cell-permeable indole compound that acts as a potent and highly selective inhibitor of SIRT1 (IC50 = 98 nM). It inhibits other sirtuin family deacetylases only at much higher concentrations (IC50 = 19.6 and 48.7 μM for SIRT2 and SIRT3, respectively) and shows no inhibitory effect against class I and II HDACs or NAD glycohydrolase even at concentrations as high as 100 μM. Shown to be orally bioavailable with a serum half-life of 136 minutes in mice in vivo.

Biologische Aktivit?t

Selective inhibitor of SIRT1 that does not inhibit histone deacetylase (HDAC) or other sirtuin deacetylase family members (IC 50 values are 98, 19600, 48700, > 100000 and > 100000 nM for SIRT1, SIRT2, SIRT3, HDAC and NADase respectively). Enhances p53 acetylation in response to DNA damaging agents.

6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 204)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32820 60
career henan chemical co 		+86-0371-86658258 +8613203830695
 sales@coreychem.com China 29886 58
Biochempartner 		0086-13720134139
candy@biochempartner.com CHINA 965 58
Changzhou PBpharmaceutical R&D Co.,Ltd 		0519-83990708
info@pbpharm.com CHINA 498 58
Hubei xin bonus chemical co. LTD 		86-13657291602
linda@hubeijusheng.com CHINA 22963 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873
 sales@chemdad.com China 39894 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 31991 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250
 1026@dideu.com China 23325 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471
 sales@sarms4muscle.com China 10473 58
CD Chemical Group Limited 		+8615986615575
 info@codchem.com China 20342 58

49843-98-3()Verwandte Suche:

  • 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE
  • 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE, >95%
  • (S)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
  • SEN0014196
  • 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide EX-527 Selisistat
  • EX 527, >=98%
  • EX 527 (Selisistat)
  • Selisistat 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxaMide
  • Selisistat - EX 527
  • EX 527; EX527
  • CS-1862
  • Selisistat (SEN0014196
  • SELISISTAT;EX 527;EX527;SEN0014196
  • EX-527; EX-527; EX-527; SELISISTAT.
  • 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide >
  • (S)-EX-527
  • 1H-Carbazole-1-carboxamide, 6-chloro-2,3,4,9-tetrahydro-
  • 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE USP/EP/BP
  • Selisistat
  • EX 527 (SEN0014196)
  • SIRT1 Inhibitor III
  • SIRT1 Inhibitor III EX-527 EX527
  • EX-527/SEN0014196, EX527
  • Selisista
  • 49843-98-3
  • C13H13ON2Cl
  • Inhibitors
  • Inhibitor
  • Other enzyme inhibitors and activators
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