2,4-Diisocyanat-toluol, Mischungenmit 2,6-Diisocyanat-toluol Chemische Eigenschaften,Einsatz,Produktion Methoden
ERSCHEINUNGSBILD
FARBLOSE BIS SCHWACH GELBE FLüSSIGKEIT ODERKRISTALLE MIT STECHENDEM GERUCH. VERF?RBT SICH SCHWACH GELB BEI KONTAKT MIT LUFT.
CHEMISCHE GEFAHREN
Kann polymerisieren unter Einfluss von Basen, terti?ren Aminen und Acylchloriden. Feuer- und Explosionsgefahr. Beim Verbrennen Bildung giftiger D?mpfe und Gase mit Stickstoffoxiden und Isocyanaten. Reagiert leicht mit Wasser, S?uren und Alkoholen unter Druckanstieg und Explosionsgefahr.
ARBEITSPLATZGRENZWERTE
TLV: 0.005 ppm (als TWA); 0.02 ppm (als STEL); Sensibilisierung; Krebskategorie A4 (nicht klassifizierbar als krebserzeugend für den Menschen); (ACGIH 2005).
MAK: Sensibilisierung der Atemwege; Krebserzeugend Kategorie 3A; (DFG 2005).
AUFNAHMEWEGE
Aufnahme in den K?rper durch Inhalation der D?mpfe und des Aerosols und durch Verschlucken.
INHALATIONSGEFAHREN
Beim Verdampfen bei 20°C kann schnell eine gesundheitssch?dliche Kontamination der Luft eintreten.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION: Substanz, Dampf der Substanz und Aerosol reizen die Augen, die Haut und die Atemwege. Inhalation des Dampfes kann zu asthma?hnlichen Reaktionen führen. Inhalation des Dampfes kann zu chemischer Bronchitis, Lungenentzündung und Lungen?dem führen. Exposition weit oberhalb der Arbeitsplatzgrenzwerte kann zum Tod führen. Die Auswirkungen treten u.U. verz?gert ein. ?rztliche Beobachtung notwendig.
WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION
Wiederholter oder andauernder Kontakt kann zu Hautsensibilisierung führen. Wiederholte oder andauernde Inhalation kann asthmatische Beschwerden hervorrufen. M?glicherweise krebserzeugend für den Menschen.
R-S?tze Betriebsanweisung:
R26:Sehr giftig beim Einatmen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R40:Verdacht auf krebserzeugende Wirkung.
R42/43:Sensibilisierung durch Einatmen und Hautkontakt m?glich.
R52/53:Sch?dlich für Wasserorganismen, kann in Gew?ssern l?ngerfristig sch?dliche Wirkungen haben.
S-S?tze Betriebsanweisung:
S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
Beschreibung
Toluene diisocyanate (TDI), (OCN)2C6H3CH3, is a water-white to pale-yellow liquid with a sharp, pungent odor. It reacts with water to release carbon dioxide. The specific gravity is 1.22, which is heavier than water. TDI is toxic by inhalation and ingestion, and is a strong irritant to skin and other tissue, particularly the eyes. The TLV is 0.005 ppm in air, and the IDLH is 10 ppm. The target organs are the respiratory system and the skin. The four-digit UN identification number is 2078. The NFPA 704 designation is health 3, flammability 1, and reactivity 3. The white section at the bottom of the diamond has a W with a slash through it, indicating water reactivity. The primary uses of TDI are in the manufacture of polyurethane foams, elastomers, and coatings.
Chemische Eigenschaften
colourless to light yellow liquid
Physikalische Eigenschaften
Clear, colorless to light yellow liquid with a pungent, fruity odor. Odor threshold concentration in
air is 2.14 ppm
v (Leonardos et al., 1969).
Verwenden
Occupational asthma is the principal cause of work-related respiratory disease in the industrial world. Toluene-2,4-diisocyanate (TDI) is one of the most common respiratory sensitizers leading to occupational asthma.
Definition
ChEBI: A toluene meta-diisocyanate in which the isocyanato groups are at positions 2 and 4 relative to the methyl group on the benzene ring.
Allgemeine Beschreibung
2,4-TDI is an environmental contaminant belonging to the class of diisocyanates. It is commercially used as a starting material for varnishes, paints, elastomers, polyurethane foams, wire enamels, etc.
Air & Water Reaktionen
Reacts with water with the evolution of carbon dioxide and formation of insoluble polyureas that are relatively nontoxic and inert [Merck 11th ed. 1989)].
Reaktivit?t anzeigen
Tolylene-2,4-diisocyanate is explosive in the form of vapor when exposed to heat, flame or sparks. Undergoes potentially violent polymerization reaction with strong bases or acyl chlorides. Reacts with water to liberate carbon dioxide. Potential explosion if stored in polyethylene containers due to absorption of water through the plastic. Emits very toxic fumes of oxides of nitrogen when heated to decomposition [Lewis, 3rd ed., 1993, p. 1251].
Hazard
Toxic by ingestion and inhalation; strong
irritant to skin and tissue, especially to eyes. Respiratory
sensitization.
Health Hazard
Can cause death. Contact with skin may cause allergic eczema. Substance is very corrosive to eyes. Chronic exposure may cause chronic lung disease. As a vapor TDI is a powerful irritant to the respiratory tract. Chronic loss of respiratory function may occur. Acute asthmatic bronchitis or frank asthma may occur. A splash in the eyes of workmen has caused keratitis and conjunctivitis. Tolylene-2,4-diisocyanate causes inflammation of the skin, also chemical pneumonitis and pulmonary edema.
Brandgefahr
When heated to decomposition Tolylene-2,4-diisocyanate emits very toxic fumes of cyanide and nitrogen oxides. Reacts violently with amines, alcohol, bases and warm water causing fire and explosion hazards. Avoid strong oxidizers, water, acids, bases, amines, etc., cause foam and splatter. Avoid heating. Hazardous polymerization may occur. Concentrated alkaline compound such as sodium hydroxide or tertiary amines may cause run-away polymerization. Slow, not hazardous polymerization may occur above 235F.
Flammability and Explosibility
TDI is a combustible liquid (NFPA rating = 1). Explosive limits in air are 0.9 to
9.5% by volume. Carbon dioxide or dry chemical extinguishers should be used for
TDI fires.
Chemische Reaktivit?t
Reactivity with Water: A non violent reaction occurs forming carbon dioxide gas and an organic base; Reactivity with Common Materials: No reactions; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Slow polymerization occurs at temperatures above 113°F. The reaction is not hazardous; Inhibitor of Polymerization: Not pertinent.
Sicherheitsprofil
Confirmed carcinogen.
Poison by ingestion, inhalation, and
intravenous routes. Human systemic effects
by inhalation: unspecified changes to the
eyes and sense of smell, respiratory
obstruction, cough, sputum, and other
pulmonary and gastrointestinal changes.
Mutation data reported. A severe skin and
eye irritant. Capable of producing severe
dermatitis and bronchial spasm. A common
air contaminant. Combustible when exposed
to heat or flame. Explosive in the form of
vapor when exposed to heat or flame. To
fight fire, use dry chemical, CO2. Potentially
violent polymerization reaction with bases
or acyl chlorides. Reaction with water
releases carbon dioxide. Storage in
polyethylene containers is hazardous due to
absorption of water through the plastic.
When heated to decomposition it emits
highly toxic fumes of NOx. See also
ISOCYANATES.
Carcinogenicity
Acute toxicity. Industrial experience has demonstrated
that acute exposure to TDI vapors can produce severe irritant effects on mucous membranes, the respiratory
tract, and the eyes. An acute attack of an asthma-like
syndrome may occur. Exposure to high concentrations
may lead to chemical bronchitis with severe bronchospasm,
chemical pneumonitis, pulmonary edema, headache, and
insomnia.With sufficient exposure, all persons would appear
to experience these effects even on their first exposure.
Chronic and subchronic toxicity. Repeated
exposures at lower concentrations of TDI may produce a
chronic-like syndrome in many people. Symptoms may
include coughing, wheezing, tightness or congestion in the
chest, and shortness of breath and appear to be
related to hypersensitization. Interstitial pulmonary fibrosis
does not occur from moderately elevated exposures to TDI
(mean 0.07, peak 0.2 ppm).
Exposure to TDI may lead to immunological sensitization.
Some individuals become sensitized on first exposure; others
may develop symptoms after exposure over days, months, or
years. Other workers have experienced only minimal or
no respiratory symptoms for several months of low level
exposure, then suddenly develop acute asthmatic reactions to
the same level. The nature of the sensitization process is
unknown, and many authors have referred to it as an
“allergy;” the respiratory response in sensitized people is
referred to as true asthma, comparable to asthma excited by
pollens and other exoallergens. Some TDI-sensitized people,
however, have no history of prior allergic disease.
Environmental Fate
Chemical/Physical. Slowly reacts with water forming carbon dioxide and polyureas (NIOSH,
1997; Windholz et al., 1983).
Lager
work with TDI should be conducted in
a fume hood to prevent exposure by inhalation, and splash goggles and impermeable
gloves should be worn at all times to prevent eye and skin contact.
l?uterung methode
It is purified by fractionation in a vacuum and should be stored in a dry atmosphere. It is soluble in organic solvents but reacts with H2O, alcohols (slowly) and amines, all of which could cause explosive polymerisation. It darkens on exposure to light. It has a sharp pungent odour, is TOXIC and is IRRITATING TO THE EYES. [Siefken Justus Liebigs Ann Chem 562 75, 96, 127 1949, Bayer Angew Chem 59 257 1947.] It is a reagent for covalent crosslinking of proteins [Wold Methods Enzymol 25 623 1972.] [Beilstein 13 IV 243.]
Inkompatibilit?ten
Contact with strong oxidizers may cause fires and explosions. Contact with water,
acids, bases, and amines can lead to reactions that liberate heat and CO2 and cause
violent foaming and spattering. TDI will attack some forms of plastic, rubber, and
coatings.
Waste disposal
Excess TDI and waste material containing this substance should be placed in an
appropriate container, clearly labeled, and handled according to your institution's
waste disposal guidelines.
Vorsichtsma?nahmen
Occupational workers should be careful during use and waste disposal of toluene diisocyanate. Use and storage of toluene diisocyanate requires precautions. It polymerizes under the infl uence of bases, tertiary amines, and acyl chlorides with fi re or explosion hazard. On combustion, it forms toxic vapors and gases, including nitrogen oxides and isocyanates. Toluene diisocyanate reacts readily with water, acids, and alcohols, and causes explosion hazard. The development of any unusual signs or symptoms, such as headache, increased pain or a discharge from the eyes, increased redness or pain or a pus-like discharge in the area of a skin burn within 24 h after exposure to toluene diisocyanate, requires immediate medical support to the exposed worker.
2,4-Diisocyanat-toluol, Mischungenmit 2,6-Diisocyanat-toluol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
