Nafarelin Acetate Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Nafarelin acetate is a synthetic decapeptide agonist analog of the natural
gonadotropin-releasing hormone, differing in the amino acid at position 6 where
D-naphthylalanine has been substituted for glycine. This substitution gives nafarelin
greater potency and a substantially longer half-life than the endogenous hormone.
Nafarelin acetate administered as a nasal spray, suppresses estrogen levels on repeated
dosing and is indicated for the management of endometriosis. It also has orphan drug
status for use in precocious puberty.
Verwenden
Nafarelin Acetate is a gonadotropin-releasing hormone agonist. Treatment with Nafarelin improves sleep disturbances and anxiety-depression. Nafarelin is also used in the treatment of estrogen-dependent gynecologic disorders such as endometriosis and uterine leiomyomas.
Clinical Use
Nafarelin acetate, contains D Nal(2)6 [Nal = 3-(2-naphthyl)-Ala] in place of Gly6, but the C-terminus, Gly10-NH2, is identical
with natural GnRH. Nafarelin acetate is available as a 0.2% nasal spray for the relief
of endometriosis. Estrogen, of course, is needed for the growth of endometrial tissue; thus, decreased estrogen leads to shrinkage of errant endometrial tissue. The observed side effects of nafarelin acetate are related to falling estrogen levels and include decreased libido,
amenorrhea, hot flashes, and vaginal dryness. When used consistently, nafarelin acetate will
inhibit ovulation and stop menstruation.
Nafarelin acetate also is used in children, male and female, for the treatment of central
precocious puberty. By suppressing the release of LH, the estradiol or testosterone levels fall to
prepubertal levels; early secondary sexual development is arrested, linear growth and skeletal
maturation are slowed, and in girls, menstruation stops.
Nafarelin Acetate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte