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Nafarelin Acetate

Nafarelin Acetate Struktur
86220-42-0
CAS-Nr.
86220-42-0
Englisch Name:
Nafarelin Acetate
Synonyma:
NAFARELIN ACETATE;Nafarelin impurity;NAFARELIN ACETATE HYDRATE;Nafarelin Acetate n-Hydrate;Nafarelin acetate naphthalene;Nafarelin acetate salt hydrate;Nafarelin Acetate Hydrate (1:x:x);Luteinizing hormone-releasing factor (pig), 6-(3-(2-naphthalenyl)-D-alanine)-, acetate (salt), hydrate;Luteinizing hormone-releasing factor (swine), 6-(3-(2-naphthalenyl)-D-alanine)-, acetate (salt), hydrate;5-OXO-L-PROLYL-L-HISTIDYL-L-TRYPTOPHYL-L-SERYL-L-TYROSYL-3-(2-NAPHTHYL)-D-ALANYL-L-LEUCYL-L-ARGINYL-L-PROLYLGLYCINAMIDE ACETATE HYDRATE
CBNumber:
CB6154226
Summenformel:
C68H89N17O16
Molgewicht:
1400.54
MOL-Datei:
86220-42-0.mol

Nafarelin Acetate Eigenschaften

Schmelzpunkt:
>181oC (dec.)
storage temp. 
2-8°C
L?slichkeit
H2O: >5mg/mL
Aggregatzustand
solid
Farbe
white
EPA chemische Informationen
Nafarelin acetate (86220-42-0)

Sicherheit

WGK Germany  3

Nafarelin Acetate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Nafarelin acetate is a synthetic decapeptide agonist analog of the natural gonadotropin-releasing hormone, differing in the amino acid at position 6 where D-naphthylalanine has been substituted for glycine. This substitution gives nafarelin greater potency and a substantially longer half-life than the endogenous hormone. Nafarelin acetate administered as a nasal spray, suppresses estrogen levels on repeated dosing and is indicated for the management of endometriosis. It also has orphan drug status for use in precocious puberty.

Verwenden

Nafarelin Acetate is a gonadotropin-releasing hormone agonist. Treatment with Nafarelin improves sleep disturbances and anxiety-depression. Nafarelin is also used in the treatment of estrogen-dependent gynecologic disorders such as endometriosis and uterine leiomyomas.

Clinical Use

Nafarelin acetate, contains D Nal(2)6 [Nal = 3-(2-naphthyl)-Ala] in place of Gly6, but the C-terminus, Gly10-NH2, is identical with natural GnRH. Nafarelin acetate is available as a 0.2% nasal spray for the relief of endometriosis. Estrogen, of course, is needed for the growth of endometrial tissue; thus, decreased estrogen leads to shrinkage of errant endometrial tissue. The observed side effects of nafarelin acetate are related to falling estrogen levels and include decreased libido, amenorrhea, hot flashes, and vaginal dryness. When used consistently, nafarelin acetate will inhibit ovulation and stop menstruation.
Nafarelin acetate also is used in children, male and female, for the treatment of central precocious puberty. By suppressing the release of LH, the estradiol or testosterone levels fall to prepubertal levels; early secondary sexual development is arrested, linear growth and skeletal maturation are slowed, and in girls, menstruation stops.

Nafarelin Acetate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Nafarelin Acetate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 65)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Zibo Hangyu Biotechnology Development Co., Ltd
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Cellmano Biotech Limited
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Wuhan Jingkang en Biomedical Technology Co., Ltd
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Watson Biotechnology Co.,Ltd
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sales01@watsonbiotech.cn China 5819 58

86220-42-0()Verwandte Suche:


  • NAFARELIN ACETATE HYDRATE
  • 5-OXO-L-PROLYL-L-HISTIDYL-L-TRYPTOPHYL-L-SERYL-L-TYROSYL-3-(2-NAPHTHYL)-D-ALANYL-L-LEUCYL-L-ARGINYL-L-PROLYLGLYCINAMIDE ACETATE HYDRATE
  • Luteinizing hormone-releasing factor (pig), 6-(3-(2-naphthalenyl)-D-alanine)-, acetate (salt), hydrate
  • Luteinizing hormone-releasing factor (swine), 6-(3-(2-naphthalenyl)-D-alanine)-, acetate (salt), hydrate
  • Nafarelin acetate naphthalene
  • 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-3-(2-naphthyl)-D-alanyl-L-leucyl-L-arginyl-L-prolylglycinamide acetate salt hydrate
  • Nafarelin acetate salt hydrate
  • NAFARELIN ACETATE
  • Nafarelin Acetate n-Hydrate
  • Nafarelin Acetate Hydrate (1:x:x)
  • Nafarelin impurity
  • 5-OXO-L-PROLYL-L-HISTIDYL-L-TRYPTOPHYL-L-SERYL-L-TYROSYL-3-(2-NAPHTHYL)-D-ALANYL-L-LEUCYL-L-ARGINYL-L-PROLYLGLYCINAMIDE ACETATE HYDRATE
  • 86220-42-0
  • 86220-42-1
  • C66H83N17O13C2H4O2H2O
  • C68H89N17O16
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