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territrem A

territrem A Struktur
70407-19-1
CAS-Nr.
70407-19-1
Englisch Name:
territrem A
Synonyma:
territrem A;TERRITREM A(RG);Territrem A(95%);PubChem ID: 115079;(4aR)-4a,6,6a,12,12a,12b-Hexahydro-4aβ,12aβ-dihydroxy-9-(7-methoxy-1,3-benzodioxol-5-yl)-4,4,6aα,12bα-tetramethyl-4H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-1,11(5H)-dione;4H,11H-Naphtho[2,1-b]pyrano[3,4-e]pyran-1,11(5H)-dione, 4a,6,6a,12,12a,12b-hexahydro-4a,12a-dihydroxy-9-(7-methoxy-1,3-benzodioxol-5-yl)-4,4,6a,12b-tetramethyl-, (4aR,6aR,12aS,12bS)-
CBNumber:
CB61359936
Summenformel:
C28H30O9
Molgewicht:
510.536
MOL-Datei:
70407-19-1.mol

territrem A Eigenschaften

storage temp. 
Store at -20°C
L?slichkeit
DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
Aggregatzustand
A solid

Sicherheit

territrem A Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Territrem A is a mycotoxin originally isolated from A. terreus that irreversibly inhibits acetylcholinesterase (AChE; IC50 = 24 nM for the electric eel enzyme). It is toxic to mice, inducing tremors with a median tremulous dose of 0.31 mg/kg, and has an LD50 value of 17.6 mg/kg.

Verwenden

Territrem A is an α-pyrone tremorgenic mycotoxin first identified from an Aspergillus terreus strain by Ling and colleagues at Taiwan National University in 1979. Territrem A is a potent insecticide acting via irreversible inhibition of acetylcholinesterase (AChE). The binding mechanism is very different from typical irreversible AChE inhibitors like neostigmine and the organophospates.

Einzelnachweise

Territrems, tremorgenic mycotoxins of Aspergillus terreus. Ling K.L. et al., Appl. Env. Microbiol. 1979, 37, 355.
Toxicity and anticholinesterase activity of the fungal metabolites territrems to the corn earworm, Helicoverpa zea. Dowd P.F. et al., Entomol. Exp. Appl. 1992, 65, 57.
Territrem B, a tremorgenic mycotoxin that inhibits acetylcholinesterase with a noncovalent yet irreversible binding mechanism. Jen-Wei Chen J-W. et al., J. Biol. Chem. 1999, 274, 34916.

territrem A Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


territrem A Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 18)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
info@efebio.com China 9806 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774
sales@glpbio.cn China 6777 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
sales@chemegen.com China 11218 58
Chengdu Jiuding Chemical Technology Co., Ltd. - Song Bo 18584079237
312074905@qq.com China 2505 58
Meng Cheng Technology (Shanghai) Co., LTD 400-820-6829
sales@mitachieve.com China 8860 58
TargetMol Chemicals Inc. 4008200310
marketing@tsbiochem.com China 24644 58
Shanghai Saikerui Biotechnology Co. , Ltd. 021-58000709 15900491054
info@scrbio.com China 10329 58
Nanjing Shizhou Biology Technology Co.,Ltd 025-85560043 15850508050
rose.shi@synzest.com China 6210 58
Nanjing Shizhou Biology Technology Co.,Ltd 025-85560043 15850508050
cindy.huang@synzest.com China 12000 58

70407-19-1()Verwandte Suche:


  • territrem A
  • (4aR)-4a,6,6a,12,12a,12b-Hexahydro-4aβ,12aβ-dihydroxy-9-(7-methoxy-1,3-benzodioxol-5-yl)-4,4,6aα,12bα-tetramethyl-4H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-1,11(5H)-dione
  • TERRITREM A(RG)
  • PubChem ID: 115079
  • 4H,11H-Naphtho[2,1-b]pyrano[3,4-e]pyran-1,11(5H)-dione, 4a,6,6a,12,12a,12b-hexahydro-4a,12a-dihydroxy-9-(7-methoxy-1,3-benzodioxol-5-yl)-4,4,6a,12b-tetramethyl-, (4aR,6aR,12aS,12bS)-
  • Territrem A(95%)
  • 70407-19-1
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