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Papain

Papain Struktur
9001-73-4
CAS-Nr.
9001-73-4
Bezeichnung:
Papain
Englisch Name:
Papain
Synonyma:
arbuz;apain;Velardon;IMMOBILIZED PAPAIN;Papain, Suspension;Papain;caroid;Papase;Vermizym;papainum
CBNumber:
CB6135333
Summenformel:
C9H14N4O3
Molgewicht:
226.23246
MOL-Datei:
9001-73-4.mol

Papain Eigenschaften

Flammpunkt:
29 °C
storage temp. 
2-8°C
L?slichkeit
H2O: soluble1.2mg/mL
Aggregatzustand
lyophilized powder
Farbe
almost white
Wasserl?slichkeit
Soluble in water, insoluble in most organic solvents.
Merck 
7016
Stabilit?t:
Hygroscopic
InChI
InChI=1S/C9H14N4O3/c10-2-1-8(14)13-7(9(15)16)3-6-4-11-5-12-6/h4-5,7H,1-3,10H2,(H,11,12)(H,13,14)(H,15,16)
InChIKey
CQOVPNPJLQNMDC-UHFFFAOYSA-N
SMILES
C(O)(=O)C(NC(=O)CCN)CC1NC=NC=1
EPA chemische Informationen
Papain (9001-73-4)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 42/43-42-36/37/38-20/21/22-10
S-S?tze: 36-36/37-26-24-22-45-23-36/37/39
WGK Germany  3
RTECS-Nr. RU4950000
TSCA  Yes
HS Code  35079090
Toxizit?t TDLo orl-man: 71 mg/kg:GIT JCGADC 9,127,87
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H334 Kann bei Einatmen Allergie, asthmaartige Symptome oder Atembeschwerden verursachen. Sensibilisierung der Atemwege Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS08.jpg" width="20" height="20" /> P261, P285, P304+P341, P342+P311,P501
Sicherheit
P261 Einatmen von Staub vermeiden.
P284 Atemschutz tragen.
P304+P340 BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.
P342+P311 Bei Symptomen der Atemwege: GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Papain Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R42/43:Sensibilisierung durch Einatmen und Hautkontakt m?glich.
R42:Sensibilisierung durch Einatmen m?glich.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S24:Berührung mit der Haut vermeiden.
S22:Staub nicht einatmen.

Chemische Eigenschaften

cream to light brown powder

Verwenden

Papain may cause allergic manifestation .Person handling this material should be protected against inhalation of dust and contact with the skin or eyes.

Application

Papain (EC 3.4.22.2) is a protease derived from the latex portion of the papaya plant ( Carica papaya ), and is gathered by scoring the surface of the mature, unripe fruit, after which the latex is collected and dried (Schwimmer, 1981) . Drying can occur by one of several methods: sun, oven, or spray drying; end products having the highest activity are obtained by spray drying. Papain has broad-spectrum enzyme activity over a wide pH and temperature range, and it cleaves at basic amino acids or those having large hydrophobic side chains. Resulting peptides having terminal hydrophobic amino acids can result in a product with a bitter aftertaste. For this reason, papain is usually combined with other enzymes in the production of flavorings. Because papain is a thiol protease, oxidation of its cysteine residue under certain conditions can reduce the enzyme’s activity or potency. For this reason papain preparations often contain reducing agents such as sodium metabisulfite. Papain is economically available commercially in both liquid and powder forms. It has the longest history of use in meat systems and is the basis for some of the popular tenderizing sprinkle-on products that can be purchased by home consumers (Enzyme Development Corporation, 1999).

Definition

papain: A protein-digesting enzymeoccurring in the fruit of the West Indianpapaya tree (Carica papaya). It isused as a digestant and in the manufactureof meat tenderizers.

Allgemeine Beschreibung

Papain (Papase), the dried and purifiedlatex of the fruit of Carica papaya L. (Caricaceae), can digestprotein in either acidic or alkaline media; it is best at a pH between4 and 7 and at 65°C to 90°C. It occurs as light brownishgray to weakly reddish brown granules, or as a yellowishgray to weakly yellow powder. It has a characteristic odor andtaste and is incompletely soluble in water to form an opalescentsolution. The commercial material is prepared by evaporatingthe juice, but the pure enzyme has also been preparedand crystallized. In medicine, it has been used locally in variousconditions similar to those for which pepsin is used. Ithas the advantage of activity over a wider range of conditions,but it is often much less reliable. Intraperitoneal instillation ofa weak solution has been recommended to counteract a tendencyto develop adhesions after abdominal surgery, and severalenthusiastic reports have been made about its value underthese conditions. Papain has been reported to cause allergiesin persons who handle it, especially those who are exposed toinhalation of the powder.

Sicherheitsprofil

Poison by intraperitoneal route. Human systemic effects by ingestion: changes in structure or function of esophagus. Experimental teratogenic and reproductive effects. An allergen. When heated to decomposition it emits toxic fumes of NOx.

l?uterung methode

A suspension of 50g of papain (freshly ground in a mortar) in 200mL of cold water is stirred at 4o for 4hours, then filtered through a Whatman No 1 filter paper. The clear yellow filtrate is cooled in an ice-bath while a rapid stream of H2S is passed through it for 3hours, and the suspension is centrifuged at 2000rpm for 20minutes. Sufficient cold MeOH is added slowly with stirring to the supernatant to give a final MeOH concentration of 70 vol%. The precipitate, collected by centrifugation for 20minutes at 2000rpm, is then dissolved in 200mL of cold water, the solution is saturated with H2S, centrifuged, and the enzyme is again precipitated with MeOH. The process is repeated four times. [Bennett & Niemann J Am Chem Soc 72 1798 1950.] Papain has also been purified by affinity chromatography on a column of GlyGlyTyrArg-agarose [Stewart et al. J Am Chem Soc 109 3480 1986].

Papain Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Papain Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 491)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shaanxi Dideu Medichem Co. Ltd
+86-29-81148696 +86-15536356810
1022@dideu.com China 3882 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12835 58
Hebei Weibang Biotechnology Co., Ltd
+8617732866630
bess@weibangbio.com China 18151 58
Hangzhou ICH Biofarm Co., Ltd
+86-0571-28186870; +undefined8613073685410
sales@ichemie.com China 1001 58
airuikechemical co., ltd.
+undefined86-15315557071
sales02@sdzhonghuimaterial.com China 983 58
BINBO BIOLOGICAL CO.,LTD
+8618629063126
info@binbobiological.com China 423 58
Hebei Zhuanglai Chemical Trading Co Ltd
+86-16264648883 +86-16264648883
niki@zlchemi.com China 2691 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Hangzhou FandaChem Co.,Ltd.
+8615858145714
FandaChem@Gmail.com China 9087 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
sales@fine-chemtech.com CHINA 885 55

9001-73-4(Papain)Verwandte Suche:


  • Papain Coarse-enzyme
  • Papain
  • Vermizym
  • Papain, for biochemistry
  • papain from carica papaya
  • papain from papaya latex
  • PAPAIN,POWDER,PURIFIED
  • PAPAIN-HYDROLYZEDPORKMEAT
  • ADOLPH'SMEATTENDERIZER
  • PAPAINPOWDER
  • papayotim
  • PAPAIN 2 X crystalline extrapure
  • papainum
  • Papayaze
  • Papain from papaya latex,Papainase
  • Papain (1 g)
  • caroid
  • nematolyt
  • PapainPowder[SodiumMetabisulfiteFree]
  • P-Nitrophenyl--D-Maltohexoside
  • PapainPurified
  • PapainExPapayaLatex(E.C.3.4.22.2)
  • PapainFreezeDried
  • summetrin
  • tromasin
  • vegetablepepsin
  • Papain food grade
  • PAPAIN 70
  • PARATHYROID HORMONE FRAGMENT*NLE8,18,TYR 34-AMIDE FR
  • PAPAIN ASEPTICALLY FILLED
  • PAPAIN LYOPHILIZED
  • PAPAIN FROM CARICA PAPAYA, POWDER, ~0.5 U/MG
  • PAPAIN CRUDE
  • Papain from Carica papaya, powder, >3 U/mg
  • PAPAIN FROM CARICA PAPAYA, ~12 U/MG
  • PAPAIN FROM CARICA PAPAYA, ~20 U/MG
  • PAPAIN FROM PAPAYA JUICE
  • FRUCTUS CHAENOMELIS
  • MultiPharM (TM) Papain 6000 U/Mg, Stabilized with SodiuM Disulfite, USP
  • Papain (1 g) (COLD SHIPMENT REQUIRED)
  • Papain, 2500 units/Mg
  • Papain from Carica papaya Latex(Suspension)
  • Papain 2x crystallized from papaya Latex
  • Papain from Carica papaya Latex(Lyophilized)
  • Papain, ≥3 units/mg
  • Papain, 2400 units/mg
  • Native Papaya latex Papain
  • Papain (Technical Grade)
  • Papain USP/EP/BP
  • papaya enzima
  • Papain, BC Grade
  • Enzyme Papain
  • Papain 1x USP ex. Papaya Latex, 6000USP U/mg
  • Papain 2x USP ex. Papaya Latex (cryst), 25U/mg
  • Papain 5x USP ex. Papaya Latex, 30000USP U/mg
  • PAPAIN Extra Pure
  • 2000units/mg,with casein as substrat
  • 1.5-10 units/mg solid
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