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Diloxanid

diloxanide Struktur
579-38-4
CAS-Nr.
579-38-4
Bezeichnung:
Diloxanid
Englisch Name:
diloxanide
Synonyma:
RD3803;RD 3803;RD-3803;Diloxanid;diloxanide;Diloxanida;diloxanide USP/EP/BP;α,α-Dichloro-4'-hydroxy-N-methylacetanilide;2,2-dichloro-N-(4-hydroxyphenyl)-N-methylacetamide;2,2-dichloro-N-(4-hydroxyphenyl)-N-methyl-acetamide
CBNumber:
CB5875447
Summenformel:
C9H9Cl2NO2
Molgewicht:
234.08
MOL-Datei:
579-38-4.mol

Diloxanid Eigenschaften

Schmelzpunkt:
175°
Siedepunkt:
356.2±42.0 °C(Predicted)
Dichte
1.439±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
DMSO:33.33(Max Conc. mg/mL);142.39(Max Conc. mM)
Aggregatzustand
Solid
pka
9.95±0.15(Predicted)
Farbe
Light brown to brown

Sicherheit

Diloxanid Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Diloxanide is also active against cysts and trophozoites localized in the lumen of the intestine, and it is used for treating the carrier E. histolytica, as well as for treating asymptomatic or moderate forms of amebiasis. In the transition stage to trophozoites, the drug is less active than iodoquinol. A synonym of this drug is furamide.

Antimicrobial activity

Diloxanide inhibits E. histolytica with unusually high specificity at concentrations of 0.01–0.1 mg/L.

Acquired resistance

No resistance has been reported. Patients with dysentery have lower cure rates than cyst excreters.

Pharmazeutische Anwendungen

Dichloro(hydroxyphenyl)methylacetamide. Available as an insoluble ester, the furoate, for oral administration.

Pharmakokinetik

Human pharmacokinetic data are limited. Animal data show that diloxanide furoate is rapidly absorbed from the intestine. The furoate is hydrolyzed in the gut, leaving high intraluminal concentrations of free diloxanide. About 75% is excreted via the kidney within 48 h, mostly as a glucuronide.

Clinical Use

Furamide, or eutamide, is the 2-furoate ester of 2,2-dichloro-4 -hydroxy-N-methylacetanilide. It was developed as a resultof the discovery that various α,α-dichloroacetamidespossessed amebicidal activity in vitro. Diloxanide itself andmany of its esters are also active, and drug metabolism studiesindicate that hydrolysis of the amide is required for theamebicidal effect. Nonpolar esters of diloxanide are morepotent than polar ones. Diloxanide furoate has been used inthe treatment of asymptomatic carriers of E. histolytica. Itseffectiveness against acute intestinal amebiasis or hepaticabscesses, however, has not been established. Diloxanidefuroate is a white crystalline powder. It is administered orallyonly as 500-mg tablets and may be obtained in the UnitedStates from the CDC in Atlanta, Georgia.

Nebenwirkungen

It is well tolerated, but flatulence is common, and nausea and vomiting may occur.

Diloxanid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Diloxanid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 32)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418671 +8618949823763
sales@tnjchem.com China 34563 58
ANHUI WITOP BIOTECH CO., LTD
+8615255079626
eric@witopchemical.com China 23541 58
Shaanxi Didu New Materials Co. Ltd
+86-89586680 +86-13289823923
1026@dideu.com China 8670 58
TargetMol Chemicals Inc.

support@targetmol.com United States 38631 58
LEAPCHEM CO., LTD.
+86-852-30606658
market18@leapchem.com China 43340 58
Hebei Weibang Biotechnology Co., Ltd
+8615350571055
Sibel@weibangbio.com China 6087 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
info@efebio.com China 9806 58
Changzhou Hopschain Chemical Co.,Ltd. 0519-85528066 13775048983
sales@hopschem.com China 31553 55
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 18892239720
psaitong@jm-bio.com China 12306 58

579-38-4(Diloxanid)Verwandte Suche:


  • diloxanide
  • α,α-Dichloro-4'-hydroxy-N-methylacetanilide
  • 2,2-dichloro-N-(4-hydroxyphenyl)-N-methylacetamide
  • 2,2-dichloro-N-(4-hydroxyphenyl)-N-methyl-acetamide
  • 2,2-dichloro-N-(4-hydroxyphenyl)-N-methyl-ethanamide
  • Acetamide, 2,2-dichloro-N-(4-hydroxyphenyl)-N-methyl-
  • diloxanide USP/EP/BP
  • Diloxanid
  • Diloxanida
  • RD 3803
  • RD3803
  • RD-3803
  • infection,inhibit,Entamoeba histolytica,anti-protozoal,Parasite,amoebic colitis,Diloxanide,Inhibitor,luminal amebicide
  • 579-38-4
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