Tacedinaline
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- CAS-Nr.
- 112522-64-2
- Englisch Name:
- Tacedinaline
- Synonyma:
- acetyldinaline;CI 994;CS-617;Cl-994;Goe 5549;PD 123654;CI994, >=99%;Tacedinaline;N-Acetyldinaline;CI994 (Tacedinaline)
- CBNumber:
- CB5855542
- Summenformel:
- C15H15N3O2
- Molgewicht:
- 269.3
- MOL-Datei:
- 112522-64-2.mol
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Tacedinaline Eigenschaften
- Schmelzpunkt:
- 216.1 °C
- Siedepunkt:
- 450.6±30.0 °C(Predicted)
- Dichte
- 1.322±0.06 g/cm3(Predicted)
- RTECS-Nr.
- CU8702023
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- L?slichkeit
- Soluble in DMSO
- pka
- 13.15±0.70(Predicted)
- Aggregatzustand
- powder
- Farbe
- off-white
- Sensitive
- Air Sensitive
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
- InChIKey
- VAZAPHZUAVEOMC-UHFFFAOYSA-N
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xi |
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| R-S?tze: |
36 |
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| S-S?tze: |
26 |
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| WGK Germany |
3 |
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| HS Code |
2924.29.7790 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Tacedinaline Chemische Eigenschaften,Einsatz,Produktion Methoden
Definition
ChEBI: A benzamide obtained by formal condensation of the carboxy group of 4-acetamidobenzoic acid with one of the amino groups of 1,2-phenylenediamine. An oral cytostatic drug with impressive differential activity against leukemic cells and normal stem-cells. Al
o used in combination therapy for selected tumors including non-smoll cell lung, pancreatic, breast, and colorectal cancers.
Biologische Aktivit?t
Orally active histone deacetylase (HDAC) inhibitor (K i values are 0.41, 0.75, >100 and >100 μ M for HDAC1, HDAC3, HDAC6 and HDAC8 respectively). Mediates G 1 cell cycle arrest, inhibits proliferation and induces apoptosis in vitro and in vivo .
Tacedinaline Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Tacedinaline Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 199)Lieferanten
112522-64-2()Verwandte Suche:
- Benzamide, 4-(acetylamino)-N-(2-aminophenyl)-
- Tacedinaline
- CI 994
- N-Acetyldinaline
- 4-AcetaMido-N-(2-aMinophenyl)benzaMide
- Cl-994(Tacedinalin,N-Acetyldinalin)
- CI994 (Tacedinaline)
- CI-994 4-Acetylamino-N-(2'-aminophenyl)benzamide
- Goe 5549
- PD 123654
- CI994, >=99%
- 4-acetylamino-n-(2'-aminophenyl)benzamide
- CI 994 - PD 123654 | Tacedinaline
- -aminophenyl)benzamide
- PD-123654;CI-994;PD123654
- CS-617
- Cl-994
- CI-994 (Acetyldinaline,PD123654)
- 4-Acetamido-N-(2-aminophenyl)benzamide >
- Tacedinaline (CI994)
- Tacedinaline USP/EP/BP
- Tacedinaline (GOE-5549, PD-123654, CI-994
- acetyldinaline
- Goe5549,CI-994,Tacedinaline,inhibit,HDAC,CI 994,Inhibitor,Histone deacetylases,Apoptosis,Goe 5549
- 112522-64-2
- Inhibitors
- Inhibitor
- Apoptosis Inducers
