Ramatroban
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- CAS-Nr.
- 116649-85-5
- Englisch Name:
- Ramatroban
- Synonyma:
- Baynas;CS-1350;BAY-U3405;RAMATROBAN;RaMantroban;Ray ma music class;BAY U3405; BAY-U3405;RaMatroban(BAY-u3405);Ramatroban for research;RAFFINOSE UNDECAACETATE, D-(+)-(RG)
- CBNumber:
- CB5735921
- Summenformel:
- C21H21FN2O4S
- Molgewicht:
- 416.47
- MOL-Datei:
- 116649-85-5.mol
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Ramatroban Eigenschaften
- Schmelzpunkt:
- 134-135°
- alpha
- D +70.1° (c = 1.0 in methanol)
- Siedepunkt:
- 654.7±65.0 °C(Predicted)
- Dichte
- 1.43±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- L?slichkeit
- DMSO: ≥40mg/mL
- Aggregatzustand
- solid
- pka
- 4.60±0.10(Predicted)
- Farbe
- white
- CAS Datenbank
- 116649-85-5(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P271 |
Nur im Freien oder in gut belüfteten R?umen verwenden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Ramatroban Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Ramatroban, originally developed for the treatment of cardiovascular pathologies as
thromboembolism, was finally introduced in Japan for the treatment of allergic rhinitis. It is
a (3R)-enantiomer that can be synthesized in 5 steps from 3-oxo-1,2,3,4-
tetrahydrocarbazole by stereoselective reductive amination, using S-phenethylamine as
the chiral source, followed by hydrogenolysis, sulfonylation and finally 2-step Ncarboxyethylation.
Ramatroban is a potent antagonist of prostaglandin receptors (PGD
2,
PGH
2) and thromboxane receptors (TxA
2); accordingly, it blocks the contractions induced
by thromboxane or TxA
2-mimetics in animal and human airway smooth muscle. It also
prevents, when administered i.v., p.o. or by aerosol, bronchoconstriction induced by PGD
2
or antigen. In animal models of nasal allergy, ramatroban inhibits antigen-induced
neutrophil infiltration into nasal mucosa and also inhibits nasal symptoms. In several
species including humans, it is well-absorbed, extensively protein-bound (>95%) and
eliminated mainly as a glucuro-conjugate; in man, its terminal half-life is 2 to 3 hours.
Chemische Eigenschaften
WHite to Off-White Solid
Verwenden
A thromboxane receptor antagonist for use in the treatment of coronary artery disease.
Biologische Aktivit?t
Potent dual antagonist of TP/DP 2 (CRTH2) prostanoid receptors (K i values are 4.3, 4.5 and > 10000 nM for hDP 2 , hTP and hDP 1 receptors respectively). Suppresses PGD 2 -induced migration of human eosinophils (IC 50 = 170 nM).
Ramatroban Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Benzenesulfonamide, N-[(3R)-9-(2-cyanoethyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]-4-fluoro-
5-OXO-TETRAHYDROCARBAZOLE ETHYLENE KETAL
1,2,4,9-TETRAHYDRO-CARBAZOL-3-ONE
(R)-3-Amino-1,2,3,4-tetrahydrocarbazole
1,4-Dioxaspiro[4.5]decan-8-one
Phenylhydrazin
Downstream Produkte
Ramatroban Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 188)Lieferanten
116649-85-5()Verwandte Suche:
- BAY-U3405
- 3R-[[(4-FLUOROPHENYL)SULFONYL]AMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-PROPANOIC ACID
- (3R)-3-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propionic acid
- 3-[(3R)-3-(4-Fluorophenylsulfonylamino)-1,2,3,4-tetrahydro-9H-carbazole-9-yl]propionic acid
- (R)-3-(3-(4-fluorophenylsulfonamido)-3,4-dihydro-1H-carbazol-9(2H)-yl)propanoic acid
- RAFFINOSE UNDECAACETATE, D-(+)-(RG)
- (3R)-3-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propanoicacid
- RaMatroban(BAY-u3405)
- 9H-Carbazole-9-propanoic acid, 3-[[(4-fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-, (3R)- (9CI)
- 9H-Carbazole-9-propanoic acid, 3-[[(4-fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-, (R)-
- Baynas
- 3R-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-
- Ramatroban for research
- RaMantroban
- RAMATROBAN
- BAY U3405; BAY-U3405
- CS-1350
- 3-(1,2,3,4-tetrahydrocarbazol-9-yl)propanoic acid [(4-fluorophenyl)sulfonylamino] ester
- 9H-Carbazole-9-propanoic acid, 3-[[(4-fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-, (3R)-
- (R)-3-[3-[(4-Fluorophenyl)sulfonamido]-1,2,3,4-tetrahydro-9H-carbazol-9-yl]propanoic Acid
- Ray ma music class
- 116649-85-5
- C21H21FN2O4S
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
