1-Bromo-3-fluoro-5-methylbenzene
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- CAS-Nr.
- 202865-83-6
- Englisch Name:
- 1-Bromo-3-fluoro-5-methylbenzene
- Synonyma:
- Fluoro-5-bromotoluene;3-BROMO-5-FLUOROTOLUENE;3-FLUORO-5-BROMOTOLUENE;3-Bromo-5-fluorotoluene98%;3-Bromo-5-fluorotoluene 98%;3-Bromine-5-Fluoride Toluene;1-BROMO-3-FLUORO-5-METHYLBENZENE;Benzene, 1-bromo-3-fluoro-5-methyl-;3-Bromo-5-Fluorotoluene/5-Bromo-3-Fluorotoluene
- CBNumber:
- CB5684465
- Summenformel:
- C7H6BrF
- Molgewicht:
- 189.02
- MOL-Datei:
- 202865-83-6.mol
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1-Bromo-3-fluoro-5-methylbenzene Eigenschaften
- Siedepunkt:
- 183.4±20.0 °C(Predicted)
- Dichte
- 1.498±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- Aggregatzustand
- Liquid
- Farbe
- Colorless
- InChI
- InChI=1S/C7H6BrF/c1-5-2-6(8)4-7(9)3-5/h2-4H,1H3
- InChIKey
- CTNFNUQREIIROB-UHFFFAOYSA-N
- SMILES
- C1(Br)=CC(C)=CC(F)=C1
- CAS Datenbank
- 202865-83-6(CAS DataBase Reference)
1-Bromo-3-fluoro-5-methylbenzene Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R10:Entzündlich.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S16:Von Zündquellen fernhalten - Nicht rauchen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Verwenden
3-Bromo-5-fluorotoluene is an important halotoluene compound used as a structural component of many organic heterocyclic compounds. It has reactive groups, bromine and fluorine atoms, which can be used in substitution reactions.
Synthese
2-Bromo-6-fluoro-4-methylaniline (11.2 g, 55 mmol), diluted hydrochloric acid (28.5 mL, 6 M) and acetonitrile (300 mL) were added to a 500 mL single-neck flask, then to the mixture in flask was added dropwise slowly a solution of sodium nitrite (5.69 g, 82.4 mmol) in water (40 mL) at 0 °C. After the addition, the reaction mixture was stirred at 0 °C for 1 h; then a solution of potassium iodide (18.3 g, 110 mmol) was added to the flask in water (30 mL). After the addition, the mixture was stirred at 0 °C for 0.5 h, then stirred at rt overnight. The reaction mixture was added saturated aqueous sodium sulfite (300 mL), and the resulting mixture was concentrated in vacuo to remove acetonitrile. The residue was extracted with ethyl acetate (100 mL x 2), combining the organic layers. The combined organic layers were washed with saturated brine (100 mL), dried over anhydrous sodium sulfate, and filtered. The filtrate was concentrated in vacuo. The residue was purified by silica-gel column chromatography (ethyl acetate/petroleum ether (v/v) = 1/100) to give 1-Bromo-3-fluoro-5-methylbenzene as a white solid (13.2 g, 76%).
1-Bromo-3-fluoro-5-methylbenzene Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
1-Bromo-3-fluoro-5-methylbenzene Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 251)Lieferanten
202865-83-6()Verwandte Suche:
4-Chlor-α,α,α-trifluortoluol
4-Fluortoluol
2-Fluortoluol
4-Bromtoluol
α,α,α,3-Tetrafluortoluol
α,α,α-Trifluortoluol
2-Brom-α,α,α-trifluortoluol
3-Bromo-2-fluorotoluene
2-Brom-5-fluortoluol
Fluor
Brom
4-Brom-α,α,α-trifluor-m-toluidin
2-Brom-3-fluortoluol
4-Brom-2-fluortoluol
6-Brom-α,α,α-trifluor-m-toluidin
2-Brom-4-trifluormethylanilin
5-Brom-2-fluortoluol
3-Brom-α,α,α-trifluortoluol
- 3-FLUORO-5-BROMOTOLUENE
- 3-BROMO-5-FLUOROTOLUENE
- 3-Bromo-5-fluorotoluene 98%
- 3-Bromo-5-fluorotoluene98%
- 3-Bromo-5-Fluorotoluene/5-Bromo-3-Fluorotoluene
- Fluoro-5-bromotoluene
- 3-Bromine-5-Fluoride Toluene
- Benzene, 1-bromo-3-fluoro-5-methyl-
- 1-BROMO-3-FLUORO-5-METHYLBENZENE
- 202865-83-6
- C7H6BrFNA
- Fluorine series
- Fluorobenzene
- Halogen toluene
- Bromine Compounds
- Fluorine Compounds
