TYRPHOSTIN AG 1024 Chemische Eigenschaften,Einsatz,Produktion Methoden

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Beschreibung

The binding of insulin-like growth factor 1 (IGF-1) to the IGF-1 receptor (IGF-1R) initiates a cascade of reactions that promote cell growth and transformation by activating the PI3K/Akt signaling pathway, inhibiting apoptotic pathways, and mediating mitogenic actions. Overexpression of IGF-1R confers tumorigenic potential to cells as well as protection from apoptosis. AG-1024 is a selective inhibitor of IGF-1R that inhibits insulin-stimulated cellular proliferation and IGF-1R autophosphorylation with IC₅₀ values of 0.4 and 7 μM, respectively. At 10 nM, AG-1024 can inhibit proliferation and induce apoptosis in human breast cancer MCF-7 cells, and it inhibits autocrine growth of human prostate cancer DU145 cells with an IC₅₀ value of 2.5 μM.

Verwenden

Tyrphostin AG 1024 is an insulin-like growth factor (IGF)-I receptor antagonist.

TYRPHOSTIN AG 1024 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

TYRPHOSTIN AG 1024 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32965	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29879	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22787	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24727	58
Coresyn Pharmatech Co., Ltd.	+86-571-86626709 +86-18157142896	cbc@coresyn.com	China	9984	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58

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• 2-[[3-Bromo-5-(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]propanedinitrile
• AGS 200
• Tyrphostin
• 2-[[3-Bromo-5-(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]propanedinitrile AGS 200
• AG-1024;HY-10253; AG 1024; AGS 200
• HY-10253
• AG-1024 (Tyrphostin)
• 2-(3-broMo-5-tert-butyl-4-hydroxybenzylidene)Malononitrile
• AG1024; TYRPHOSTIN AG 1024
• AG 1024 - CAS 65678-07-1 - Calbiochem
• CS-241
• AG-1024;TYRPHOSTIN AG1024;AGS 200
• Propanedinitrile, 2-[[3-bromo-5-(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-
• TYRPHOSTIN AG 1024 USP/EP/BP
• AG-1024 Selective IGF-1R inhibitor AG1024
• IGF-1R,IGF1R,DNA-PKcs,phosphorylation,growth,AG1024,Apoptosis,Tyrphostin AG1024,Tyrphostin AG-1024,AG-1024,BCR-ABL,AG 1024,factor-1,Insulin Receptor,anti-cancer,Inhibitor,Akt,inhibit
• AG1024, 10 mM in DMSO
• 65678-07-1