AUY954 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

AUY954 is an orally bioavailable and selective agonist of the sphingosine-1-phosphate receptor 1 (S1P₁; EC₅₀ = 1.2 nM for stimulating GTPγS binding to S1P₁ in CHO cells). It is highly selective for the S1P₁ receptor with EC₅₀ values of >10,000, 1,210, >1,000, and 340 nM for S1P₂, S1P₃, S1P₄, and S1P₅ receptors, respectively. AUY954 reduces circulating lymphocytes and prevents rejection of rat heart allografts. In a rat model of experimental autoimmune neuritis, chronic treatment with AUY954 (10 mg/kg), starting on the day of immunization, almost completely prevents peripheral paralysis. In the same model, it also decreases T cell, B cell, and macrophage infiltration and perivascular demyelination in sciatic nerves.

AUY954 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

AUY954 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32002	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38460	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9806	58
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6777	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11217	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24649	58
Shanghai Yiyan Biotechnology Co. , Ltd.	021-69985186 13611928337	3427709316@qq.com	China	7979	58
Nanjing Tengyi Biotechnology Co., Ltd	025-58851786 17714337195	sales@tybiochem.com	China	7414	58

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• AUY954
• β-Alanine, N-[[2-[2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]benzo[b]thien-5-yl]methyl]-
• AUY-954 free base
• AUY 954 free base,AUY954 free base
• N-[[2-[2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]benzo[b]thien-5-yl]methyl]-β-alanine
• 820240-77-5
• C25H20F3NO2S