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Ropinirole hydrochloride

Ropinirole hydrochloride Struktur
91374-20-8
CAS-Nr.
91374-20-8
Englisch Name:
Ropinirole hydrochloride
Synonyma:
ROPINIROLE HCL;REQUIP;4-[2-(Di-n-propylamino)ethyl]-2(3H)-indolone Hydrochloride;Requi;SKF-101468A;Ropinirole HCl API;Ropinirole Hcl ,99%;Ropinirole hydrochlo;Ropinib hydrochloride;Ropinero hydrochloride
CBNumber:
CB5420618
Summenformel:
C16H25ClN2O
Molgewicht:
296.84
MOL-Datei:
91374-20-8.mol

Ropinirole hydrochloride Eigenschaften

Schmelzpunkt:
241-243°C
storage temp. 
2-8°C
L?slichkeit
H2O: >10mg/mL
Aggregatzustand
powder
Farbe
light yellow
InChI
InChI=1S/C16H24N2O.ClH/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15;/h5-7H,3-4,8-12H2,1-2H3,(H,17,19);1H
InChIKey
XDXHAEQXIBQUEZ-UHFFFAOYSA-N
SMILES
C12CC(=O)NC=1C=CC=C2CCN(CCC)CCC.Cl
CAS Datenbank
91374-20-8(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn,N,Xi
R-S?tze: 22-50/53-36/38
S-S?tze: 36-60-61-37/39-26
RIDADR  UN 3077 9/PG 3
WGK Germany  3
RTECS-Nr. NM3288250
HS Code  2933790002
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H400 Sehr giftig für Wasserorganismen. Kurzfristig (akut) gew?ssergef?hrdend Kategorie 1 Warnung GHS hazard pictogramssrc="/GHS09.jpg" width="20" height="20" /> P273, P391, P501
Sicherheit
P273 Freisetzung in die Umwelt vermeiden.

Ropinirole hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R22:Gesundheitssch?dlich beim Verschlucken.
R50/53:Sehr giftig für Wasserorganismen, kann in Gew?ssern l?ngerfristig sch?dliche Wirkungen haben.
R36/38:Reizt die Augen und die Haut.

S-S?tze Betriebsanweisung:

S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S60:Dieses Produkt und sein Beh?lter sind als gef?hrlicher Abfall zu entsorgen.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Beschreibung

ReQuip was launched in the UK as a monotherapy or in combination with low-dose levodopa for the treatment of early-stage idiopathic Parkinson's disease. An eight step (24% overall yield) synthesis from isochroman provides access to ropinirole. It is a non-ergot postsynaptic dopamine D2 agonist with activity in the extrapyramidal system. It has weak or no significant activity at α2-adrenergic, 5-HT2 receptors and is inactive at 5-HT1, benzodiazepine, GABA, α1 and β adrenoreceptors. Thus it has essentially no CNS side effects, fewer dyskinesias and on-off fluctuations. In animals, it was able to reverse all motor deficits induced by MPTP. Tolerance is not developed and ropinirole has similar postsynaptic potency to apomorphine but with significantly less stereotyped behavior.

Chemische Eigenschaften

Off-White Solid

Verwenden

An antiparkinsonian agent. A selective dopamine D2-receptor agonist

Allgemeine Beschreibung

Ropinirole hydrochloride,4-(2-(dipropylamino)ethyl)indolin-2-one hydrochloride(Requip), is a white to pale greenish yellow powder that isvery soluble in water. Ropinirole is rapidly absorbed afteroral administration with maximal plasma concentrationsgenerally reached after about 1.5 hours, and the eliminationhalf-life appears to be approximately 3 hours. Ropinirole isalso rapidly and extensively distributed from the vascularcompartment and shows low plasma protein binding that isindependent of its plasma concentration. This drug iscleared by metabolism in the liver, with only 10% being excretedunchanged. The main metabolite of ropinirole is theN-despropyl metabolite. The glucuronide of this metaboliteand the carboxylic acid metabolite, 4-carboxymethylindolin-2-one, account only for 10% of the administered dose.None of the metabolites is pharmacologically active, and theexcretion of ropinirole-derived products is mainly via theurine. The main CYP450 isozyme involved in the metabolismof ropinirole is CYP1A2. Inhibitors or inducers ofthis enzyme have been shown to alter the clearance ofropinirole.Ropinirole is believed to act as an agonist atpostsynaptic D2 receptors. Ropinirole is indicated for thetreatment of the signs and symptoms of idiopathic PD andmoderate to severe primary RLS.

Biologische Aktivit?t

Selective D 2 -like receptor agonist (D 3 > D 2 > D 4 ). Causes biphasic spontaneous locomotor activity and contralateral circling in 6-OHDA-lesioned mice. Displays antiParkinsonian activity.

Ropinirole hydrochloride Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Ropinirole hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 431)Lieferanten
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91374-20-8()Verwandte Suche:


  • Ropinirol hydrochloride
  • 4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one Hydrochloride
  • Requi
  • 1,3-dihydro-4-(2-(dipropylamino)ethyl)-2h-indol-2-onemonohydrochloride
  • 1,3-dihydro-4-(2-(dipropylamino)ethyl)-2h-indol-2-onmonohydrochloride
  • 4-(2-(dipropylamino)ethyl)-2-indolinonemonohydrochloride
  • SKF-101468A
  • ROPINIROLE HYDROCHLORIDE
  • SKF 101468 hydrochloride, 4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one hydrochloride
  • 4-[2-(Dipropylamino)ethyl]-2-indolinone·hydrochloride
  • 4-[2-(Dipropylamino)ethyl]indoline-2-one·hydrochloride
  • Ropinirole Hcl ,99%
  • SKF 101468 hydrochloride
  • 4-(2-dipropylaminoethyl)-1,3-dihydroindol-2-one hydrochloride
  • Ropinirole hydrochlo
  • Ropinirole HCl API
  • 2H-Indol-2-one, 4-[2-(dipropylaMino)ethyl]-1,3-dihydro-, hydrochloride (1:1)
  • 4-(2-(DipropylaMino)ethyl)indolin-2-one hydrochloride
  • Ropinirole (as hydrochloride)
  • Ropinirole hydrochloride###Ropinirole
  • 4(2DIPROPYLAMINOETHYL)1,3DHINDOLE2ONEHCL
  • Ropinirole for peak identification 1 CRS
  • Ropinirole hydrochloride CRS
  • Ropinirole for peak identification 2 CRS
  • Ropinirole for peak identification 1
  • Ropinirole for peak identification 2
  • Ropinirole hydrochloride USP/EP/BP
  • Ropinirole HydrochlorideQ: What is Ropinirole Hydrochloride Q: What is the CAS Number of Ropinirole Hydrochloride Q: What is the storage condition of Ropinirole Hydrochloride Q: What are the applications of Ropinirole Hydrochloride
  • TIANFU-CHEM Ropinirole hydrochloride
  • Ropinirole Hydrochloride (1605205)
  • 4-[2-(Di-n-propylamino)ethyl]-2(3H)-indolone Hydrochloride
  • REQUIP
  • ROPINIROLE HCL
  • Ropinero hydrochloride
  • Ropinib hydrochloride
  • Ropiniero hydrochloride
  • 91374-20-8
  • 1374-20-8
  • 91347-20-8
  • C16H24N2OHCl
  • Ropinirole
  • Medicine intermediate
  • Inhibitors
  • Amine
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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