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GW7647

GW7647 Struktur
265129-71-3
CAS-Nr.
265129-71-3
Englisch Name:
GW7647
Synonyma:
GW647;GW7647;CS-761;GW 7647X;GWalpha 7647;GW7647, >=98%;GW7647; GW 7647;GW7647 - CAS 265129-71-3 - Calbiochem;2-(4-(2-(1-CYCLOHEXANEBUTYL)-3-CYCLOHEXYLUREIDO)ETHYL)PHENYLTHIO)-2-METHYLPROPIONIC ACID;2-((4-(2-(3-Cyclohexyl-1-(4-cyclohexylbutyl)ureido)ethyl)phenyl)thio)-2-methylpropanoic acid
CBNumber:
CB5420133
Summenformel:
C29H46N2O3S
Molgewicht:
502.75
MOL-Datei:
265129-71-3.mol

GW7647 Eigenschaften

Schmelzpunkt:
156 - 157°C
Siedepunkt:
693.9±55.0 °C(Predicted)
Dichte
1.12
storage temp. 
Store at RT
L?slichkeit
DMSO: 16 mg/mL, soluble
Aggregatzustand
White solid
pka
3.79±0.10(Predicted)
Farbe
white
InChIKey
PKNYXWMTHFMHKD-UHFFFAOYSA-N

Sicherheit

WGK Germany  3

GW7647 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Peroxisome proliferator-activated receptor-α (PPARα) is a ligand-activated transcription factor involved in the regulation of lipid homeostasis. Activation of PPARα results in expression of a variety of genes, particularly those involved in fatty acid β-oxidation, binding, and transport. GW 7647 is a potent, selective agonist of human and murine PPARα It activates human PPARα, PPARγ, and PPARδ with EC50 values of 0.006, 1.1 and 6.2 μM, respectively, in a GAL4-PPAR binding assay. Similar EC50 values of 0.001, 1.3, and 2.9 were observed with the murine receptors. GW 7647 lowered triglycerides 93% and 60% in fat-fed hamsters and rats, respectively, at a dose of 3 mg/kg.

Verwenden

GW7647 has been used as a peroxisome proliferator-activated receptor α (PPAR α) ligand:
  • in defatting medium to treat primary human hepatocytes
  • to test its effect on the glycolytic function in cardiomyocytes
  • to test its effect on infant mouse heart
  • in breast cancer MDA-MB-231 cells to activate PPARs

Definition

ChEBI: A monocarboxylic acid that is 2-(phenylsulfanyl)isobutyric acid in which the phenyl group is substituted at the para- position by a 3-aza-7-cyclohexylhept-1-yl group in which the nitrogen is acylated by a (cyclohexylamino)carbonyl group.

Allgemeine Beschreibung

A cell-permeable urea-substituted thioisobutyric acid (ureido-TiBA) compound that acts as a potent and selective PPARα agonist (PPARα, γ and δ - EC50 = 6 nM, 1.1 μM and 6.2 μM for human; 1 nM, 1.3 μM and 2.9 μM for murine, respectively). Also displays in vivo lipid-lowering activity in rats.

Biologische Aktivit?t

Potent and highly selective PPAR α agonist (EC 50 values are 6, 1100 and 6200 nM for human PPAR α , PPAR γ and PPAR δ receptors respectively). Modulates oleate metabolism and mitochondrial enzyme gene expression in mature myotubules in vitro . Has lipid-lowering effects following oral administration in vivo .

GW7647 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


GW7647 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 128)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32070 58
Career Henan Chemica Co
+86-0371-86658258 +8613203830695
laboratory@coreychem.com China 30241 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471
sales@sarms4muscle.com China 10473 58
InvivoChem
+1-708-310-1919 +1-13798911105
sales@invivochem.cn United States 6391 58
LEAP CHEM CO., LTD.
+86-852-30606658
market18@leapchem.com China 24727 58
Hangzhou MolCore BioPharmatech Co.,Ltd.
+86-057181025280; +8617767106207
sales@molcore.com China 49734 58
ShenZhen Trendseen Biological Technology Co.,Ltd.
13417589054
trendseenbio@gmail.com China 11681 58
Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525
masar@topule.com China 8467 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
Amadis Chemical Company Limited
571-89925085
sales@amadischem.com China 131957 58

265129-71-3()Verwandte Suche:


  • 2-[[4-[2-[[(Cyclohexylamino)carbonyl](4-cyclohexylbutyl)amino]ethyl]phenyl]thio]-2-methylpropa
  • GW7647, >=98%
  • Propanoic acid, 2-[[4-[2-[[(cyclohexylaMino)carbonyl](4-cyclohexylbutyl)aMino]ethyl]phenyl]thio]-2-Methyl-
  • GWalpha 7647
  • GW 7647X
  • 2-((4-(2-(((Cyclohexylamino)carbonyl)-(4-cyclohexylbutyl)amino)ethyl)phenyl)thio)-2-methylpropanoicacid
  • 2-[[4-[2-[[(CYCLOHEXYLAMINO)CARBONYL](4-CYCLOHEXYLBUTYL)AMINO]ETHYL]PHENYL]THIO]-2-METHYLPROPANOIC ACID
  • 2-(4-(2-(1-CYCLOHEXANEBUTYL)-3-CYCLOHEXYLUREIDO)ETHYL)PHENYLTHIO)-2-METHYLPROPIONIC ACID
  • GW7647
  • GW647
  • GW7647; GW 7647
  • CS-761
  • GW7647 - CAS 265129-71-3 - Calbiochem
  • 2-((4-(2-(3-Cyclohexyl-1-(4-cyclohexylbutyl)ureido)ethyl)phenyl)thio)-2-methylpropanoic acid
  • 265129-71-3
  • C29H46N2O3S
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • PPAR and RXR Regulators
  • Gene Regulation and Expression
  • Intracellular receptor
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