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Allopregnanolone

Allopregnanolone Struktur
516-54-1
CAS-Nr.
516-54-1
Englisch Name:
Allopregnanolone
Synonyma:
Brexanolone;ALLOPREGNANOLONE;Anlotinib Dihydrochloride;(3a)-Allopregnanolone;allotetrahydroprogesterone;3α-hydroxy-5α-pregnan-20-one;1-((3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethan-1-one;5α-P;ASN16541;3α-OH-DHP
CBNumber:
CB5418550
Summenformel:
C21H34O2
Molgewicht:
318.49
MOL-Datei:
516-54-1.mol

Allopregnanolone Eigenschaften

Schmelzpunkt:
176-178°
alpha 
D +87.7° (abs alc)
Siedepunkt:
431.2±18.0 °C(Predicted)
Dichte
1.053±0.06 g/cm3(Predicted)
storage temp. 
Store at RT
L?slichkeit
chloroform: 20 mg/mL, clear, colorless
pka
15.12±0.70(Predicted)
Aggregatzustand
White solid
Farbe
white
Merck 
13,272
BRN 
3211363
Stabilit?t:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
InChIKey
AURFZBICLPNKBZ-SYBPFIFISA-N
CAS Datenbank
516-54-1(CAS DataBase Reference)

Sicherheit

S-S?tze: 22-24/25
WGK Germany  3
RTECS-Nr. TU4383000
F  10

Allopregnanolone Chemische Eigenschaften,Einsatz,Produktion Methoden

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Beschreibung

Allopregnanolone is an endogenous inhibitory pregnane neurosteroid that is synthesized from progesterone . It acts as a positive allosteric modulator of GABAA receptors at nM concentrations (exhibiting the greatest potentiation at isoforms containing δ subunits) and of GABAC receptors at μM concentrations. Allopregnanolone displays effects similar to other GABAA receptor potentiators such as benzodiazepines, including potent anticonvulsant, anxiolytic, and sedative activity.

Verwenden

(3α)-Allopregnanolone acts as a GABAA receptor positive allosteric modulator. (3α)-Allopregnanolone is a metabolite of Progesterone (P755900). (3α)-Allopregnanolone is a neuroactive steroid present in the blood and also the brain.

Biologische Aktivit?t

GABA A receptor positive allosteric modulator. Neuroactive steroid.

Allopregnanolone Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Allopregnanolone Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 230)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Yanxi Chemical Co., Ltd. 		+8617531190177
 peter@yan-xi.com China 5858 58
shandong perfect biotechnology co.ltd 		+86-53169958659; +8618596095638
 sales@sdperfect.com China 294 58
Hebei Xinsheng New Material Technology Co., LTD. 		+86-16632316109
 xinshengkeji@xsmaterial.com China 1085 58
Hangzhou FandaChem Co.,Ltd. 		+8615858145714
 FandaChem@Gmail.com China 9215 55
Shanghai Yingrui Biopharma Co., Ltd. 		+86-21-33585366 - 03@
sales03@shyrchem.com CHINA 738 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32951 60
Jinan Chenghui-Shuangda Chemical Co.,Ltd 		+86-531-58897082
ericqiao@jnchsd.com CHINA 158 58
Jinan Shengqi pharmaceutical Co,Ltd 		86+18663751872
christine@shengqipharm.com CHINA 491 58
HubeiwidelychemicaltechnologyCo.,Ltd 		18627774460
faith@widelychemical.com CHINA 742 58
career henan chemical co 		+86-0371-86658258 +8613203830695
 factory@coreychem.com China 29814 58

516-54-1()Verwandte Suche:

  • 1-[(3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
  • 3-A-5-A-TETRAHYDROPROGESTERONE
  • 3-alpha,5-alpha-pregnanolone
  • 3α-OH-DHP
  • Allopregnan-3a-ol-20-one
  • (3α)-Allopregnanolone
  • 3α,5α-Tetrahydroprogesterone
  • 3α,5α-THP
  • 3α-Hydroxy-5α-dihydroprogesterone
  • 3α-Hydroxy-5α-pregnane-20-one
  • 5α-P
  • 3-alpha,5-alpha-tetrahydroprogesterone
  • 3-alpha-hydroxy-5-alpha-pregnan-20-on
  • 5alpha-Pregnan-20-one, 3alpha-hydroxy-
  • Pregnan-20-one, 3-hydroxy-, (3alpha,5alpha)-
  • 5ALPHA-PREGNAN-3ALPHA-OL-20-ONE
  • 3ALPHA-HYDROXY-5ALPHA-20-ONE
  • 3ALPHA-HYDROXY-5ALPHA-PREGNAN-20-ONE
  • 3ALPHA-OH-DHP
  • ALLOPREGNAN-3ALPHA-OL-20-ONE
  • 1-[(3R,5S,8R,9S,10S,13R,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
  • 5a-Pregnan-3alpha-ol-3-one
  • 3α-Hydroxy-5α-pregnan-20-one, 3α-OH-DHP, Allopregnan-3α-ol-20-one
  • (3alpha,5alpha)-3-hydroxypregnan-20-one
  • Alpha - Pregnan - alpha - 3 ol - twenty - one, Brexanolone
  • 5α-Pregnan-3α-ol-20-one
  • (3α,5β)-3-Hydroxy-pregnan-20-one
  • Allopregnan-3α-ol-20-one
  • (3alpha)-Allopregnanolone
  • 1-[(3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-10
  • 5alpha progesterone 3alpha alcohol 20 one (tetrahydro progesterone)
  • Allopregnan-3 alpha-ol-20-one，Allopregnanolone
  • 3α,5α-THP
  • (3α)-Allopregnanolone
  • Allopregnanolone(Brexanolone)
  • LJPC-0712
  • 3Α;5Α-THP; SAGE547; SAGE 547; SAGE-547
  • 3A-HYDROXY-5A-PREGNAN-20-ONE
  • Allopregnanolone - CAS 516-54-1 - Calbiochem
  • Brexanolone（SAGE-547）
  • 1-((3R,5S,8R,9S,10S,13S,14S,17S)-3-Hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone
  • 5alpha-Pregnan-3alpha-ol-20-one,3α-hydroxy-5α-pregnan-20-one
  • 5alpha-Pregnan-3a-ol-20-one
  • Allopregnanolone (Solution)
  • 5alpha-Pregnan-3alpha-ol-20-one,Brexanolone
  • Anlotinib Dihydrochloride
  • allotetrahydroprogesterone
  • ALLOPREGNANOLONE
  • 3α-hydroxy-5α-pregnan-20-one
  • 1-((3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethan-1-one
  • Brexanolone
  • (3a)-Allopregnanolone
  • 3α-hydroxy-5α-pregnan-20-one
  • 3α-Hydroxy-AlloProgesterone
  • Brexanolone/Allopregnan-3alpha-ol-20-one
  • Allopregnalone
  • Pregnan-20-one, 3-hydroxy-, (3α,5α)-
  • ALLOPREGNANOLONE
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