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Silymarin

Silymarin Struktur
65666-07-1
CAS-Nr.
65666-07-1
Englisch Name:
Silymarin
Synonyma:
Silybum marianum;MilkthistleP.E.exsemencardui;ymarin;Legalon;NSC4733;NSC 4733;NSC-4733;Silymarin;SILYBIN(P);Ccris 7096
CBNumber:
CB5348848
Summenformel:
C25H22O10
Molgewicht:
482.44
MOL-Datei:
65666-07-1.mol

Silymarin Eigenschaften

Schmelzpunkt:
158 °C
storage temp. 
-20°C
L?slichkeit
Acetone (Slightly), DMSO (Slightly), Methanol (Very Slightly)
Aggregatzustand
Solid
Farbe
Light Orange to Brown
InChI
InChI=1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-18-7-12(3-5-16(18)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3
InChIKey
FDQAOULAVFHKBX-UHFFFAOYSA-N
SMILES
C1(C2=CC=C3OC(C4=CC=C(O)C(OC)=C4)C(CO)OC3=C2)OC2=CC(O)=CC(O)=C2C(=O)C1O
CAS Datenbank
65666-07-1(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
S-S?tze: 22-24/25
WGK Germany  3
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H361 Kann vermutlich die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. Reproduktionstoxizit?t Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
H373 Kann die Organe sch?digen bei l?ngerer oder wiederholter Exposition. Spezifische Zielorgan-Toxizit?t (wiederholte Exposition) Kategorie 2 Warnung P260, P314, P501
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P260 Dampf/Aerosol/Nebel nicht einatmen.
P281 Vorgeschriebene pers?nliche Schutzausrüstung verwenden.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.
P314 Bei Unwohlsein ?rztlichen Rat einholen / ?rztliche Hilfe hinzuziehen.
P405 Unter Verschluss aufbewahren.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Silymarin Chemische Eigenschaften,Einsatz,Produktion Methoden

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Verwenden

Silymarin a flavonolignan complex extracted from milk thistle, has been shown to provide cytoprotective, antioxidant and hepatoprotective effects. Provides extracts such as (+)-taxifolin as an inhibitor of β-amyloid aggregation.

Indications

Milk thistle (Silybum [Carduus] marianus) is a spiny European plant with white-veined leaves and milky sap, the seed of which is used to treat liver disease.Milk thistle seed extract is used orally in the treatment of alcoholic and other cirrhoses and in Europe intravenously for its hepatoprotective effect in Amanita and other mushroom poisonings. It is grown in this country primarily as a “l(fā)iver cleanser” and is reputed to protect this organ from a wide array of toxins.Milk thistle seed contains the active principle silymarin, a complex of flavonolignan compounds including silibinin (silybin), silidianin, and silychristin.

Allgemeine Beschreibung

Silymarin is a flavonolignan, obtained from milk thistle (Silybum marianum) plant.

Mechanism of action

Silymarin is thought to protect the liver by preventing the entry of toxins into the hepatocyte and by stimulating nucleolar polymerase A, which, in turn, increases protein synthesis and liver regeneration. Silymarin undergoes enterohepatic circulation, increasing its concentration in hepatocytes. It is also an antioxidant in its own right and is considered to have some cytoprotective effect against carcinogens.

Clinical Use

Alcoholic cirrhosis has been improved (faster return of liver enzymes to baseline) in at least three trials, although one multicenter Spanish study failed to demonstrate any change in the clinical course.There is no evidence to support the use of milk thistle to increase alcohol tolerance, although it is certainly being used for this purpose. The effectiveness of silymarin for viral hepatitis is not clear, although several trials demonstrated enough benefit to encourage further studies.
Intravenous silymarin has been demonstrated to lower mortality from Amanita mushroom poisonings, but this formulation is available only in Europe.Animal studies have demonstrated hepatic protection against alcohol, acetaminophen, and mushroom toxins and protection against hepatic fibrosis with bile duct occlusion. There is also evidence of silybin protecting against cisplatin- induced nephrotoxicity in rats. It is not yet clear whether milk thistle extract offers any renal protection to humans.

Nebenwirkungen

Milk thistle appears to be remarkably safe, with loose stools due to increased bile solubility and occasional allergic reactions being the common side effects. It has not been evaluated in children or in pregnant women.There are no known serious drug or herb interactions.

Silymarin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Silymarin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 377)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Xi'an ZB Biotech Co.,Ltd
+8618591943808
sales01@xazbbio.com China 815 58
Lewoo Pharmatech(Shanghai)Co.,Ltd
+86-15800805830 +86-15800805830
miao@lewoopharma.com.cn China 184 58
Shaanxi Haibo Biotechnology Co., Ltd
+undefined18602966907
qinhe02@xaltbio.com China 997 58
Shaanxi Dideu Medichem Co. Ltd
+86-29-81148696 +86-15536356810
1022@dideu.com China 3882 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5889 58
ZhenYiBio Technology Inc
+8615309206328
alexxue@zhenyibio.com China 296 58
Nantong Guangyuan Chemicl Co,Ltd
+undefined17712220823
admin@guyunchem.com China 615 58
BINBO BIOLOGICAL CO.,LTD
+8618629063126
info@binbobiological.com China 423 58
Aurora Industry Co., Ltd.
+86-13591747876 +86-13591747876
alex1_auco@126.com China 299 58
Hebei Zhuanglai Chemical Trading Co Ltd
+86-16264648883 +86-16264648883
niki@zlchemi.com China 2691 58

65666-07-1()Verwandte Suche:


  • silybin or silybinin
  • Milkthistleextract/Silymarin
  • Milkthistleseedextract,powder=Silymarin/Silybin
  • Silybummarianumextract,seed
  • Milkthistleseedextract,fluid=Silymarin/Silybin
  • Silybummarianumseedextract,fluid
  • SILYBIN SNAP-N-SHOOT 0.1mg/mL(P)
  • SILYBIN(MIX)(RG)
  • SILYBIN(P)
  • SILYCHRISTIN SNAP-N-SHOOT 0.1mg/mL(P)
  • SILYCHRISTIN(P)
  • SILYMARINEXTRACT
  • Silymarin
  • 2-(2,3-Dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-1,4-benzodioxin-6-yl)-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one
  • Ccris 7096
  • Legalon
  • Legalon 70
  • Milk thistle (silybum marianum) extract or powder
  • Milk thistle (silybum marianum) extract or powder [seed]
  • Silymarin P.E.
  • SilyMarin(Silybin B)
  • SilyMarin, SilyMarine , Milk Thistle Extract, Milk Thistle P.E.
  • silybin or
  • 4H-1-Benzopyran-4-one, 2-[2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-
  • Milk Thistle Extract, Silymarin 80%
  • Acetone extract silymarin
  • Silymarin, >=60%
  • Silymarin 65666-07-1
  • 65666-07-1 Silymarin
  • Water-soluble silymarin
  • BioActive Silymarin
  • NanoActive Silymarin
  • Soluble Silymarin
  • Silymarin (>80%)
  • ymarin
  • Silymarin (>
  • Silymarin, Silymarine , Milk Thistle Extract
  • Silymarin 80% by UV
  • Summarily,Marilyn,MilkThistleExtract
  • Silymarin (Mixture of isomers)Q: What is Silymarin (Mixture of isomers) Q: What is the CAS Number of Silymarin (Mixture of isomers) Q: What is the storage condition of Silymarin (Mixture of isomers) Q: What are the applications of Silymarin (Mixture of isomers)
  • 80% Silymarin
  • NSC 4733
  • NSC4733
  • NSC-4733
  • Silybum marianum
  • MilkthistleP.E.exsemencardui
  • Milk Thistle Seed Extract (Silymarin 80% by UV)
  • 65666-07-1
  • 65666-01-1
  • Angiogenesis
  • Angiogenesis Inhibitors
  • BioChemical
  • Cancer Research
  • Inhibitors
  • NMN
  • 65666-07-1
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