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4-Aminohippursure

4-Aminohippuric acid Struktur
61-78-9
CAS-Nr.
61-78-9
Bezeichnung:
4-Aminohippursure
Englisch Name:
4-Aminohippuric acid
Synonyma:
PAH;P-AMINOHIPPURIC ACID;POLYNUCLEAR AROMATIC HYDROCARBONS;paha;Nefrotest;N-glycine;Aminohippuric;pah(aminoacid);AKOS BBS-00006940;p-amino-hippuricaci
CBNumber:
CB5348161
Summenformel:
C9H10N2O3
Molgewicht:
194.19
MOL-Datei:
61-78-9.mol

4-Aminohippursure Eigenschaften

Schmelzpunkt:
199-200 °C (dec.)(lit.)
Siedepunkt:
330.62°C (rough estimate)
Dichte
1.356
Brechungsindex
1.5600 (estimate)
storage temp. 
Store below +30°C.
L?slichkeit
DMF: 33 mg/ml; DMF:PBS (pH7.2) (1:30): 0.03 mg/ml; DMSO: 20 mg/ml
pka
pKa 3.8 (Uncertain)
Aggregatzustand
Crystalline Powder
Farbe
Off-white to grayish
PH
3.0-3.5 (20g/l, H2O, 20℃)
Wasserl?slichkeit
Soluble in alcohol, chloroform, benzene, and acetone. Insoluble in water, ether, carbon, and tetrachloride.
Merck 
14,442
BRN 
1213676
InChIKey
HSMNQINEKMPTIC-UHFFFAOYSA-N
CAS Datenbank
61-78-9(CAS DataBase Reference)
EPA chemische Informationen
P-Aminohippuric acid (61-78-9)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi,Xn
R-S?tze: 36/37/38-20/21/22
S-S?tze: 37/39-26-36
WGK Germany  3
8-9-23
TSCA  Yes
HS Code  29242990
Giftige Stoffe Daten 61-78-9(Hazardous Substances Data)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

4-Aminohippursure Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.

S-S?tze Betriebsanweisung:

S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

4-Aminohippuric acid is a substrate for various renal transporters that has been used in the study of anion uptake in the kidney. It is a substrate for organic anion transporter 1 (OAT1; Km = 14.3 μM in X. laevis oocytes), the human inorganic phosphate transporter (NPT1; Km = 2.66 mM in HEK293 cells), and apical multidrug resistance protein (MDR2; Km = 880 μM in HEK293 cells). 4-Aminohippuric acid is a glycine amide form of 4-aminobenzoic acid . Formulations containing 4-aminohippuric acid have been used as markers to determine renal plasma flow.

Chemische Eigenschaften

off-white to greyish crystalline powder

Verwenden

4-Aminohippuric Acid is used in the measurement of renal plasma flow as a diagnostic tool which may be applied towards kidney disorders.

Definition

ChEBI: P-aminohippuric acid is an N-acylglycine that is the 4-amino derivative of hippuric acid; used as a diagnostic agent in the measurement of renal plasma flow. It has a role as a Daphnia magna metabolite. It is a conjugate acid of a p-aminohippurate.

Allgemeine Beschreibung

Renal tubules secretes para amino hippuric acid/PAH.

Biochem/physiol Actions

Para-aminohippuric acid(PAH) is used as a marker in nutrition studies to measure the flow of blood in pigs, which inturn helps to determine the portal-drained viscera (PDV) flux of nutrients.

Synthese

4-Aminohippuric acid is prepared by reacting p-nitrobenzoyl chloride with glycine, followed by reducing the p-nitro group with tin and hydrochloric acid.

l?uterung methode

Crystallise the acid from H2O. It is soluble in organic solvents. [Cohen & McGilvery J Biol Chem 169 119 1945, 171 121 1947, Meunzen et al. J Biol Chem 26 469 1926, Beilstein 14 III 1069, 14 IV 1152.]

Einzelnachweise

[1] B. ZMBOVA . Synthesis of p-aminohippuric acid analog and its labeling by technetium-99m[J]. International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, 1989, 40 3: Pages 225-234. DOI:10.1016/0883-2889(89)90152-4.
[2] W P DEISS P P C. Studies in para-aminohippuric acid synthesis in the human: its application as a liver function test.[J]. Journal of Clinical Investigation, 1950, 29 8: 1014-1020. DOI:10.1172/JCI102332.
[3] M. SHEAT M. M Zenab F Saeed. Synthesis of Some of Azo, Triazines and Schiff Bases Compounds from 4-Aminohippuric Acid[J]. Journal of Education Science, 2009, 47 1: 1-8. DOI:10.33899/edusj.2009.57930.
[4] T SEKINE. Expression cloning and characterization of a novel multispecific organic anion transporter.[J]. The Journal of Biological Chemistry, 1997, 272 30: 18526-18529. DOI:10.1074/jbc.272.30.18526.
[5] HIROSHI UCHINO . p-Aminohippuric Acid Transport at Renal Apical Membrane Mediated by Human Inorganic Phosphate Transporter NPT1[J]. Biochemical and biophysical research communications, 2000, 270 1: Pages 254-259. DOI:10.1006/bbrc.2000.2407.

4-Aminohippursure Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


4-Aminohippursure Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 263)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shanghai Gubang New Materail Technology Co. LTD
21-51317962 +8618721305404
16728589@qq.com CHINA 272 58
Shaanxi Haibo Biotechnology Co., Ltd
+undefined18602966907
qinhe02@xaltbio.com China 997 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652
info@fdachem.com China 20284 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29791 60
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886
info@dakenam.com China 18751 58
Hangzhou FandaChem Co.,Ltd.
+8615858145714
FandaChem@Gmail.com China 9087 55
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29811 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58

61-78-9(4-Aminohippursure)Verwandte Suche:


  • |p|-AMinohippuric acid (PAH)
  • 2-[(4-aminophenyl)carbonylamino]ethanoic acid
  • 2-[[(4-aminophenyl)-oxomethyl]amino]acetic acid
  • Aminohippuric acid [USAN]
  • Hippuric acid, p-amino-
  • Hippuric acid, p-amino- (8CI)
  • Nefrotest
  • N-[(4-aminophenyl)carbonyl]glycine
  • p-Aminohippuric acid (PAH)
  • 4-Aminohippuric acid(p-Aminohippuric acid)
  • n-(4-aminobenzoyl)-glycin
  • n-(para-aminobenzoyl)glycine
  • pah(aminoacid)
  • 4-Aminohippuric acid;PAH
  • P-AMINOHIPPURIC ACID FREE ACID
  • 4-Aminohippuricacid,97%
  • Aminohippuric
  • Glycine, N-(4-aminobenzoyl)-
  • 2-[(4-aminobenzoyl)amino]acetic acid
  • N-(4-AMINOBENZOYL)GLYCINE / 4-AMINOHIPPURIC ACID
  • 4-AMINOHIPPURIC ACID BIOTECH
  • 4-Aminohippuric acid, N-(4-Aminobenzoyl)glycine, p-Aminohippuric acid
  • 4-Aminohippuric acid,99%
  • N-glycine
  • 4-AMINOHIPPURIC ACID FOR SYNTHESIS
  • 2-(4-AMinobenzaMido)acetic acid
  • Aminohippuric Acid (200 mg)
  • paha
  • p-amino-hippuricaci
  • para-aminohippuricacid
  • AKOS BBS-00006940
  • (4-AMINO-BENZOYLAMINO)-ACETIC ACID
  • 4-AMINOBENZOYL GLYCINE
  • 4-AMINOHIPPURIC ACID
  • 2-[4-AMINOPHENYLCARBOXYAMINO]-ACETIC ACID
  • LABOTEST-BB LT00053657
  • MIXTURE NO 6-POLYNUCLEAR AROMATIC HYDROCARBONS
  • N-4-AMINOHIPPURIC ACID
  • N-(4-AMINOBENZOYL)AMINOACETIC ACID
  • N-(4-AMINOBENZOYL)GLYCINE
  • N-(P-AMINOBENZOYL)-AMINOACETIC ACID
  • N-[P-AMINOBENZOYL]GLYCINE
  • P-AMINOBENZOYLGLYCINE
  • TIMTEC-BB SBB000329
  • 4-Aminohippuric Acid >
  • 4-AMINOHIPPURIC ACID USP/EP/BP
  • Aminohippuric Acid (1025351)
  • POLYNUCLEAR AROMATIC HYDROCARBONS
  • PAH
  • P-AMINOHIPPURIC ACID
  • 4-Aminohippuric Acid, ≥ 99.0%
  • 61-78-9
  • H2NC6H4CONHCH2COOH
  • H2NC6D4CONHCH2COOH
  • NH2C6H4CONHCH2COOH
  • AMINE
  • Peptide Synthesis
  • Modified Amino Acids
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