SR1824 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Peroxisome proliferator-
activated receptor γ (PPARγ) is activated by the anti-
diabetes drugs known as thiazolidinediones, including rosiglitazone and pioglitazone . Phosphorylation of PPARγ by cyclin-
dependent kinase 5 (Cdk5) causes dysregulation of genes whose expression is altered in obesity, including adiponectin. SR 1824 is a non-
agonist PPARγ ligand (K
i = 10 nM) which blocks Cdk5-
mediated phosphorylation. It does not inhibit activation of PPARγ by rosiglitazone .
Verwenden
SR 1824 is a non-agonist Peroxisome proliferator-activated receptor γ (PPARγ) ligand.
SR1824 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte