2-Fluorphenylessigsaeure
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- CAS-Nr.
- 451-82-1
- Bezeichnung:
- 2-Fluorphenylessigsaeure
- Englisch Name:
- 2-Fluorophenylacetic acid
- Synonyma:
- O-fluorine acid;RARECHEM AL BO 0110;2-Fluorophenylacetic;o-flurophenylacetic acid;2-Fluorphenylessigsaeure;2-fluoro-benzeneaceticaci;2-FLUOROPHENYLACETIC ACID;O-FLUOROPHENYLACETIC ACID;2-fluoro-benzeneacetic acid;2-Fluorophenylaceticacid97%
- CBNumber:
- CB5297100
- Summenformel:
- C8H7FO2
- Molgewicht:
- 154.14
- MOL-Datei:
- 451-82-1.mol
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2-Fluorphenylessigsaeure Eigenschaften
- Schmelzpunkt:
- 60-62 °C (lit.)
- Siedepunkt:
- 203.5°C (rough estimate)
- Dichte
- 1.1850 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- L?slichkeit
- Chloroform (Sparingly), Methanol (Slightly)
- Aggregatzustand
- Solid
- pka
- 4.01±0.10(Predicted)
- Farbe
- Off-White
- BRN
- 775955
- InChI
- InChI=1S/C8H7FO2/c9-7-4-2-1-3-6(7)5-8(10)11/h1-4H,5H2,(H,10,11)
- InChIKey
- RPTRFSADOICSSK-UHFFFAOYSA-N
- SMILES
- C1(CC(O)=O)=CC=CC=C1F
- CAS Datenbank
- 451-82-1(CAS DataBase Reference)
- NIST chemische Informationen
- O-fluorophenylacetic acid(451-82-1)
- EPA chemische Informationen
- Benzeneacetic acid, 2-fluoro- (451-82-1)
2-Fluorphenylessigsaeure Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R38:Reizt die Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S27:Beschmutzte, getr?nkte Kleidung sofort ausziehen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
white to off-white shiny crystals or crystalline
Verwenden
2-Fluorophenylacetic acid was used:
- in the synthesis of thiazolino[3,2-c]pyrimidin-5,7-diones and N-[2-(3,4-dichlorophenyl)-ethyl]-N′-[2-(2-fluorophenyl)-ethyl]-ethane-1,2-diamine
- as chiral derivatizing agent for determination of enantiomeric composition of chiral, nonracemic compounds by 19F NMR spectroscopy
Allgemeine Beschreibung
2-Fluorophenylacetic acid is chiral derivatizing agent for determination of enantiomeric composition of chiral, nonracemic compounds by
19F NMR spectroscopy.
Synthese
The Schlenk tube was heated under a high vacuum, pre-dried with calcium chloride, and filled with CO2 gas. Bis(4-methoxyphenyl)zinc magnesium chloride lithium chloride (12.8 ml, 0:39 M in THF, 5.0 mmol) was added, and CO2 was passed through the solution for 5 minutes. The reaction mixture was stirred at 25 °C for 6 hours. Diethyl ether (50 ml) was added, and the organic phase was extracted with 2M NaOH (3×50 ml). The combined aqueous phases were acidified with 2M HCl (pH <5) and extracted with diethyl ether (3×50 ml). The combined organic phases were dried over sodium sulfate, and the solvent was removed in vacuo. 2-Fluorophenylacetic acid was obtained in a yield of 100%.
2-Fluorphenylessigsaeure Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2-Fluorphenylessigsaeure Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 432)Lieferanten
451-82-1(2-Fluorphenylessigsaeure)Verwandte Suche:
- RARECHEM AL BO 0110
- O-FLUOROPHENYLACETIC ACID
- 2-FLUOROPHENYLACETIC ACID
- 2-fluoro-benzeneaceticaci
- Acetic acid, (o-fluorophenyl)-
- Benzeneacetic acid, 2-fluoro-
- o-Fluorophenylacetic Acid 2-Fluorophenylacetic Acid
- 2-Fluorophenylacetic acid, 98+%
- 2-Fluorophenylacetic acid 97%
- 2-Fluorophenylaceticacid97%
- 2-fluoro-benzeneacetic acid
- 2-Fluorophenylacetic
- O-fluorine acid
- o-flurophenylacetic acid
- 2-Fluorophenylacetic acid, 98% 10GR
- Orthofluorophenyl acetic acid
- Adjacent fluorine benzene acetic acid
- o-2-Fluorophenylacetic Acid
- 2-Fluorphenylessigsaeure
- 2-Fluorophenylacetic acid ISO 9001：2015 REACH
- 451-82-1
- FA - FL
- Organic Building Blocks
- C8
- Carbonyl Compounds
- Carboxylic Acids
- Building Blocks
- Analytical Standards
- Alphabetic
- Analytical Chromatography Product Catalog
- Aryl Fluorinated Building Blocks
- Building Blocks
- Phenylacetic acid series
- FA - FL
- F
- Alphabetic
- Carboxylic Acids
- Carbonyl Compounds
- C8
- Phenylacetic acid
- Fluorobenzene
- Aromatic Phenylacetic Acids and Derivatives
- Imidazoles
- Other Fluorinated Organic Building Blocks
- Organic Fluorinated Building Blocks
- Organic Building Blocks
- Fluorinated Building Blocks
- Chemical Synthesis
- Carboxylic Acids
- Carbonyl Compounds
- C7-C8
