4-HYDROXYISOLEUCINE
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- CAS-Nr.
- 55399-93-4
- Englisch Name:
- 4-HYDROXYISOLEUCINE
- Synonyma:
- HIL;4-Hydroxyisoleucine;HYDROXYISOLEUCINE, 4-;4 -Hydroxyisoleucic acid;HYDROXYISOLEUCINE, 4-(FG);(4S)-4-Hydroxy-L-isoleucine;Hydroxyisoleucine 55399-93-4;TIANFU-CHEM 4-HYDROXYISOLEUCINE;4-HYDROXYISOLEUCINECAS:55399-93-4;[DISCONTINUED] Replaced by KIT-00008502-0HK
- CBNumber:
- CB5274835
- Summenformel:
- C6H13NO3
- Molgewicht:
- 147.17
- MOL-Datei:
- 55399-93-4.mol
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4-HYDROXYISOLEUCINE Eigenschaften
- Schmelzpunkt:
- 223-224℃
- Siedepunkt:
- 331.6±32.0 °C(Predicted)
- Dichte
- 1.181±0.06 g/cm3 (20 ºC 760 Torr)
- Flammpunkt:
- 147℃
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- L?slichkeit
- Methanol (Slightly), Water (Slightly)
- pka
- 2.41±0.25(Predicted)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- Optische Aktivit?t
- [α]/D +32.5±2.0°, c = 1 in H2O
- BRN
- 4128096
- InChI
- InChI=1S/C6H13NO3/c1-3(4(2)8)5(7)6(9)10/h3-5,8H,7H2,1-2H3,(H,9,10)/t3-,4-,5-/m0/s1
- InChIKey
- OSCCDBFHNMXNME-YUPRTTJUSA-N
- SMILES
- C(O)(=O)[C@@H](N)[C@@H](C)[C@H](C)O
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xi |
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| R-S?tze: |
36/37/38 |
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| S-S?tze: |
26 |
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| WGK Germany |
3 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P271 |
Nur im Freien oder in gut belüfteten R?umen verwenden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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4-HYDROXYISOLEUCINE Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
4-Hydroxyisoleucine is an amino acid that has been found in fenugreek (
T. foenum graecum) seeds and has antidiabetic activity. It increases glucose-stimulated insulin release from isolated rat islets and isolated perfused rat pancreas when used at a concentration of 200 μM.
In vivo, 4-hydroxyisoleucine increases PI3K activity in muscle and liver in rats when administered at a dose of 18 mg/kg and in muscle in a rat model of type 2 diabetes induced by nicotinamide and streptozotocin (STZ; ) when administered at 25 mg/kg. 4-Hydroxyisoleucine (50 mg/kg per day for four weeks) decreases plasma glucose, triglyceride, LDL, HDL, and cholesterol levels in an STZ-induced rat model of type 1 diabetes.
Occurrence
4-hydroxyisoleucine has been extracted and purified from fenugreek seeds, which are known in traditional medicine for their antidiabetic properties.
Verwenden
(4S)-4-Hydroxy-L-isoleucine is 4S isomer of 4-Hydroxyisoleucine, which is used as a treatment for type II diabetes.
Definition
ChEBI: An L-isoleucine derivative that is L-isoleucine bearing a (4S)-hydroxy substituent.
Biologische Aktivit?t
4-Hydroxyisoleucine increases glucose-induced insulin release, in the concentration range of 100 micromol/l to 1 mmol/l, through a direct effect on isolated islets of Langerhans from both rats and humans.
4-HYDROXYISOLEUCINE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
4-HYDROXYISOLEUCINE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 188)Lieferanten
55399-93-4()Verwandte Suche:
- 4-HYDROXYISOLEUCINE; 4-HYDROXY-L-ISOLEUCINE
- HIL
- HYDROXYISOLEUCINE, 4-
- 2-AMINO-2,3,5-TRIDEOXY-3-METHYL-D-XYLONIC ACID
- (2S,3R,4S)-4-HYDROXYISOLEUCINE MAJOR ISOMER AND (2R,3R,4S)-4-HYDROXYISOLEUCINE MINOR ISOMER
- [DISCONTINUED] Replaced by KIT-00008502-0HK
- HYDROXYISOLEUCINE, 4-(FG)
- (2S,3R,4S)-2-Amino-4-hydroxy-3-methylpentanoic acid
- (4S)-4-Hydroxy-L-isoleucine
- L-Ribonic acid, 2-amino-2,3,5-trideoxy-3-methyl-
- (4S)-4-Hydroxy-L-isoleucine from fenugreek seed, >=98.0% (TLC)
- 4-HYDROXYISOLEUCINECAS:55399-93-4
- TIANFU-CHEM 4-HYDROXYISOLEUCINE
- 4 -Hydroxyisoleucic acid
- Hydroxyisoleucine 55399-93-4
- 4-Hydroxyisoleucine
- 55399-93-4
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
