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JW74

JW74 Struktur
863405-60-1
CAS-Nr.
863405-60-1
Englisch Name:
JW74
Synonyma:
JW74;JW74;JW 74;JW74 >=98% (HPLC);Inhibitor,JW74,JW-74,JW 74,inhibit,Wnt;5-(((4-(4-Methoxyphenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)methyl)-3-(p-tolyl)-1,2,4-oxadiazole;4-[4-(4-Methoxyphenyl)-5-[[[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]thio]-4H-1,2,4-triazol-3-yl]-pyridine;Pyridine, 4-[4-(4-methoxyphenyl)-5-[[[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]thio]-4H-1,2,4-triazol-3-yl]-
CBNumber:
CB52731079
Summenformel:
C24H20N6O2S
Molgewicht:
456.52
MOL-Datei:
863405-60-1.mol

JW74 Eigenschaften

Siedepunkt:
699.4±65.0 °C(Predicted)
Dichte
1.35±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
L?slichkeit
DMSO: ≥20mg/mL
pka
1.63±0.10(Predicted)
Aggregatzustand
powder
Farbe
white to beige

Sicherheit

WGK Germany  3

JW74 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Tankyrases (TNKS) are poly(ADP-ribose) polymerases (PARPs) that cleave NAD+ to produce nicotinamide and ADP-ribose, which is then covalently attached to an acceptor protein in a process known as poly(ADP-ribosyl)ation. TNKS have key roles in the Wnt signaling pathway as part of the β-catenin destruction complex. JW 74 is an inhibitor of the catalytic PARP domain of TNKS1/2 that blocks canonical Wnt signaling with an IC50 value of 790 nM. It increases the levels of Axin2 and decreases β-catenin levels in colorectal cancer (CRC) cells, leading to down-regulation of Wnt target genes. JW 74 inhibits the growth of CRC xenograft tumors in mice. JW 74 induces apoptosis and differentiation in osteosarcoma cell lines.

Verwenden

JW 74 is an inhibitor that affects cell cycle progression and induces apoptosis and differentiation in osteosarcoma cell lines.

JW74 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

JW74 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 51)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32820 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32024 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695
 laboratory@coreychem.com China 30241 58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd 		+86-18791163155 +86-13119157289
 13119157289@163.com China 2971 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
MedChemexpress LLC 021-58955995
sales@medchemexpress.cn United States 4861 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185
 sales-cpd@caerulumpharma.com China 3466 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
 info@efebio.com China 9806 58
Changzhou Hopschain Chemical Co.,Ltd. 0519-85528066 13775048983
 sales@hopschem.com China 31553 55
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720
 klq@cw-bio.com China 4420 55
  • JW74
  • 4-[4-(4-Methoxyphenyl)-5-[[[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]thio]-4H-1,2,4-triazol-3-yl]-pyridine
  • JW74;JW 74
  • Pyridine, 4-[4-(4-methoxyphenyl)-5-[[[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]thio]-4H-1,2,4-triazol-3-yl]-
  • JW74 >=98% (HPLC)
  • Inhibitor,JW74,JW-74,JW 74,inhibit,Wnt
  • 5-(((4-(4-Methoxyphenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)methyl)-3-(p-tolyl)-1,2,4-oxadiazole
  • 863405-60-1
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