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RS-102895 hydrochloride

RS-102895 hydrochloride Struktur
1173022-16-6
CAS-Nr.
1173022-16-6
Englisch Name:
RS-102895 hydrochloride
Synonyma:
3-trihydroxybenzene;RS-102895;RS 102895;RS102895;1'-(4-(Trifluoromethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one hydrochloride;Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one, 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-, hydrochloride;Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one, 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-, hydrochloride (1:1)
CBNumber:
CB52729375
Summenformel:
C21H22ClF3N2O2
Molgewicht:
426.86
MOL-Datei:
1173022-16-6.mol

RS-102895 hydrochloride Eigenschaften

storage temp. 
Inert atmosphere,Room Temperature
L?slichkeit
DMF: 25 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml; Ethanol: 2 mg/ml
Aggregatzustand
Powder
Farbe
White to off-white

Sicherheit

RS-102895 hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

The chemokine CCL2, also known as monocyte chemotactic protein-1 (MCP-1), stimulates leukocyte chemotaxis to sites of inflammation via signaling through the MCP-1 receptor, CCR2. RS 102895 is a spiropiperidine compound that acts as a CCR2 antagonist (IC50 = 0.36 μM). It inhibits the related CCR1 receptor with an IC50 value of 17.8 μM and inhibits adrenergic α1a, α1d, and 5HT1A receptors with IC50 values of 0.13, 0.32, and 47 μM, respectively. RS 102895 prevents chemotaxis of THP-1 cells (IC50 = 1.7 μM) when MCP-1 is presented as a chemoattractant.

Verwenden

RS 102895 Hydrochloride is used as a leukocyte infiltrate marker for rosacea diagnosis.

RS-102895 hydrochloride Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

RS-102895 hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 55)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32951 60
Biochempartner 		0086-13720134139
candy@biochempartner.com CHINA 965 58
career henan chemical co 		+86-0371-86658258 +8613203830695
 factory@coreychem.com China 29814 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32077 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
 sales@hzclap.com CHINA 6312 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
LEAP CHEM CO., LTD. 		+86-852-30606658
market18@leapchem.com China 24727 58
Henan Aochuang Chemical Co.,Ltd. 		+86-0371-63689365 +8618638391208
 sales@aochuangchem.com China 9237 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38468 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054
 trendseenbio@gmail.com China 11681 58

1173022-16-6()Verwandte Suche:

  • Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one, 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-, hydrochloride
  • 3-trihydroxybenzene
  • Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one, 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-, hydrochloride (1:1)
  • RS-102895;RS 102895;RS102895
  • 1'-(4-(Trifluoromethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one hydrochloride
  • 1173022-16-6
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