N-palMitoyl-1-deoxysphinganine (M18:0/16:0) Chemische Eigenschaften,Einsatz,Produktion Methoden
Allgemeine Beschreibung
N-C16-deoxysphinganine Commonly referred to as 1-deoxydihydroceramide (1-deoxyDHCer), is the
N-acylated form of 1-deoxysphinganine, a potent inhibitor of sphingolipid metabolism. The
N-acyl group can be 16, 20 and 24 carbon chain.
N-acylsphinganines (dihydroceramides) are synthesized by the acylation of sphingoid bases in the presence of ceramide synthases (CerS).
Biochem/physiol Actions
N-acylsphinganines (dihydroceramides) levels are lower during ceramide synthase inhibition. They are intermediates of ceramide and dihydrosphingolipids synthesis. Treatment of MCF7 cancer cells with fenretinide alters sphingolipid metabolism.
N-palMitoyl-1-deoxysphinganine (M18:0/16:0) Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
