2-Amino-4-bromo-3-fluorobenzoic acid
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- CAS-Nr.
- 1416013-62-1
- Englisch Name:
- 2-Amino-4-bromo-3-fluorobenzoic acid
- Synonyma:
- 140622;Ethanol,5-diazenyl-;Oxymetazoline Impurity 10;3-BROMO-6-CARBOXY-2-FLUOROANILINE;2-amino-4-bromo-3-fluorobenzoicaci;2-Amino-3-fluoro-4-bromobenzoic acid;2-Amino-4-bromo-3-fluorobenzoic acid;Benzoic acid, 2-amino-4-bromo-3-fluoro-
- CBNumber:
- CB52697454
- Summenformel:
- C7H5BrFNO2
- Molgewicht:
- 234.02
- MOL-Datei:
- 1416013-62-1.mol
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2-Amino-4-bromo-3-fluorobenzoic acid Eigenschaften
- Siedepunkt:
- 332.0±42.0 °C(Predicted)
- Dichte
- 1.877±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 4.37±0.10(Predicted)
- Aggregatzustand
- powder
- Farbe
- Off white
- InChI
- InChI=1S/C7H5BrFNO2/c8-4-2-1-3(7(11)12)6(10)5(4)9/h1-2H,10H2,(H,11,12)
- InChIKey
- SFRJQFICUQFDFU-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC=C(Br)C(F)=C1N
2-Amino-4-bromo-3-fluorobenzoic acid Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
2-Amino-4-bromo-3-fluorobenzoic acid is an important pharmaceutical and organic intermediate ingredient used in the synthesis of avibactam sodium, an FDA-approved non-beta-lactam β-lactamase inhibitor used in combination with ceftazidime (Avycaz). It is used for the treatment of complicated intra-abdominal infections, urinary tract infections, and pyelonephritis.
Verwenden
2-Amino-4-Bromo-3-Fluorobenzoic Acid is used in preparation of Quinazoline compounds as KRAS modulators and antitumor agents.
Synthese
The synthesis of 2-Amino-4-bromo-3-fluorobenzoic acid is as follows:
To a mixture of 6-bromo-7-fluoroindoline-2,3-dione (18.9 g, 77.5 mmol) in 2 N NaOH (350 mL) at 0 oC, H2O2 (30%, 40 mL) was added. The mixture was stirred at room temperature for 16 h. The mixture was quenched with Na2SO3, and the mixture was acidified with conc. HCl to adjust pH to 2. The precipitate was collected by filtration and dried to afford the desired product as a white solid (17 g, 94% yield).
2-Amino-4-bromo-3-fluorobenzoic acid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2-Amino-4-bromo-3-fluorobenzoic acid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 168)Lieferanten
- 2-Amino-4-bromo-3-fluorobenzoic acid
- 3-BROMO-6-CARBOXY-2-FLUOROANILINE
- 140622
- Benzoic acid, 2-amino-4-bromo-3-fluoro-
- Ethanol,5-diazenyl-
- 2-amino-4-bromo-3-fluorobenzoicaci
- 2-Amino-3-fluoro-4-bromobenzoic acid
- Oxymetazoline Impurity 10
- 1416013-62-1
