GSK 2801
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- CAS-Nr.
- 1619994-68-1
- Englisch Name:
- GSK 2801
- Synonyma:
- GSK 280;CS-1607;GSK2801;GSK-2801;GSK 2801;GSK2801, >98%;GSK-2801; GSK 280;GSK2801 GSK-2801;GSK2801;GSK-2801;GSK 2801;1-[1-[2-(Methylsulfonyl)phenyl]-7-propoxy-3-indolizinyl]ethanone
- CBNumber:
- CB52668513
- Summenformel:
- C20H21NO4S
- Molgewicht:
- 371.45
- MOL-Datei:
- 1619994-68-1.mol
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GSK 2801 Eigenschaften
- Dichte
- 1.23±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- L?slichkeit
- insoluble in H2O; ≥18.55 mg/mL in DMSO; ≥2.82 mg/mL in EtOH with gentle warming and ultrasonic
- Aggregatzustand
- solid
- Farbe
- Light yellow to khaki
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
22 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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GSK 2801 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
BAZ2A/B are bromodomain-containing proteins whose biological function is believed to function similarly to ACF1, the
Drosophila BAZ2B ortholog. ACF complexes play roles in establishing regular nucleosome spacing during chromatin assembly and influencing different remodeling outcomes at target loci. BAZ2A and BAZ2B constitute the central scaffolding protein of the nucleolar remodeling complex (NoRC) that regulates the expression of noncoding RNAs. GSK2801 is a selective, cell-permeable inhibitor of the BAZ2 family of bromodomain-containing proteins (IC
50s = 9-350 nM in a BAZ2B AlphaScreen). It binds to BAZ2A and BAZ2B with K
d values of 0.26 and 0.14 μM, respectively, and does not interact with the bromodomains of BRD4(BD1), CREBBP, TRIM24/TIF1α, PB1(BD5), PCAF, or ATAD2. See the
Structural Genomics Consortium (SGC) website for more information.
Verwenden
GSK2801 is a selective cell-permeable inhibitor of the BAZ2 (bromodomain-containing protein) interfering with nucleosome spacing during chromatin assembly.
GSK 2801 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
GSK 2801 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 84)Lieferanten
- GSK 2801
- GSK2801
- GSK-2801
- 1-(7-(2-Methylsulfonyl-phenyl)-4-propoxy-1-aza-bicyclo[4.3.0]nona-2,4,6,8-tetraen-9-yl)-ethanone
- 1-(1-(2-(methylsulfonyl)phenyl)-7-propoxyindolizin-3-yl)ethanone
- 1-[1-[2-(Methylsulfonyl)phenyl]-7-propoxy-3-indolizinyl]ethanone
- Ethanone, 1-[1-[2-(methylsulfonyl)phenyl]-7-propoxy-3-indolizinyl]-
- GSK-2801; GSK 280
- GSK 280
- GSK2801, >98%
- CS-1607
- GSK2801;GSK-2801;GSK 2801
- 1-[1-(2-Methanesulfonyl-phenyl)-7-propoxy-indolizin-3-yl]-ethanone
- GSK2801 GSK-2801
- inhibit,Inhibitor,GSK-2801,TNBC,BAZ2A,GSK2801,Epigenetic Reader Domain,Apoptosis,BAZ2B,cetyl-lysine,orally,GSK 2801
- 1619994-68-1
- Inhibitors
