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HYDROXYPROPYL METHYL CELLULOSE ACETATE SUCCINATE

HYDROXYPROPYL METHYL CELLULOSE ACETATE SUCCINATE Struktur
71138-97-1
CAS-Nr.
71138-97-1
Englisch Name:
HYDROXYPROPYL METHYL CELLULOSE ACETATE SUCCINATE
Synonyma:
HPMCAS;HyproMellose Acetate Succinate;HPMCAS AS-MF;acetic acid, methanol;Hypromellose Acetate Succinate (100 mg);Hypromellose Acetate Succinate (1335279);Acetate hydroxypropyl methylcellulose succinate;HYDROXYPROPYL METHYL CELLULOSE ACETATE SUCCINATE;Hydroxypropyl Methyl cellulose acetate succinate JPE;2-hydroxypropylmethylehter,acetatehydrogenbutanedioate
CBNumber:
CB5265556
Summenformel:
C10H22O9
Molgewicht:
0
MOL-Datei:
Mol file

HYDROXYPROPYL METHYL CELLULOSE ACETATE SUCCINATE Eigenschaften

Schmelzpunkt:
>203°C (dec.)
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
L?slichkeit
Practically insoluble in ethanol (95%), hexane, unbuffered water, and xylene. On the addition of acetone, or a mixture of ethanol (95%) and dichloromethane (1 : 1), a clear or turbid viscous solution is produced. Hypromellose acetate succinate also forms a clear or turbid solution in buffers of pH greater than 4.5 with the rank order of solubility for the various grades increasing with the ratio of acetyl over succinoyl substitution. The exact pH value at which the polymer starts to swell and dissolve depends on the buffer type and ionic strength, although the rank order for the different grades is independent of the buffer used. No solvent has been found to completely dissolve hypromellose acetate succinate polymer; the resulting clear or turbid solutions significantly scatter light in both static and dynamic light scattering experiments, indicating that the polymer may exist as colloids or aggregates. The data is collated from the Shin-Etsu Chemical Co. Ltd and the research work of the authors (R Chen, BC Hancock, and RM Shanker).
Aggregatzustand
Solid
Farbe
White to Off-White
Stabilit?t:
Hygroscopic
LogP
-0.591 (est)

Sicherheit

HS Code  3912390000

HYDROXYPROPYL METHYL CELLULOSE ACETATE SUCCINATE Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

soluble in organic solvents, including acetone, methanol, aqueous ethanol

Verwenden

Hypromellose Acetate Succinate HPMCAS;is a pharmaceutical compound comprising enzalutamide.

Vorbereitung Methode

Hypromellose acetate succinate is produced by the esterification of hypromellose with acetic anhydride and succinic anhydride, in a reaction medium of a carboxylic acid, such as acetic acid, and using an alkali carboxylate, such as sodium acetate, as catalyst. The fibrous reaction product is precipitated out by adding a large volume of water to the reaction medium. Purification is achieved by thorough washing with water. The granular grade of hypromellose acetate succinate that is so obtained can be pulverized to a fine powder if required.

Pharmazeutische Anwendungen

Hypromellose acetate succinate is commonly used in oral pharmaceutical formulations as a film coating, as well as an enteric coating material for tablets or granules. It is a solubility enhancing agent via solid dispersion. Hypromellose acetate succinate is insoluble in gastric fluid but will swell and dissolve rapidly in the upper intestine. For aqueous film-coating purposes, a dispersion of hypromellose acetate succinate fine powder and triethyl citrate (as a plasticizer) in water is commonly utilized. Organic solvents can also be used as vehicles for applying this polymer as a film coating.
Hypromellose acetate succinate may be used alone or in combination with other soluble or insoluble binders in the preparation of granules with sustained drug-release properties; the release rate is pH-dependent.
Dispersions of poorly soluble drugs with hypromellose acetate succinate are prepared using techniques such as mechanical grinding, solvent evaporation, and melt extrusion.

Sicherheit(Safety)

The safety and pharmacological profiles of hypromellose acetate succinate are similar to those of other ether and ester derivatives of cellulose. All nonclinical studies reported in the literature identify no target organs for toxicity by hypromellose acetate succinate. It has also been reported that hypromellose acetate succinate does not alter fertility in rats, does not produce any developmental anomalies in rats and rabbits, and does not alter perinatal and postnatal development in rats when assessed up to 2500 mg/kg body-weight

Lager

Hypromellose acetate succinate should be stored in a well-closed container, in a cool, dry place. In such storage conditions, hypromellose acetate succinate is a stable material. Hypromellose acetate succinate is hygroscopic. It is hydrolyzed to acetic acid and succinic acid, and the hypromellose polymer starts to form if dissolved in 1 mol/L sodium hydroxide for more than two hours. The hydrolysis is the main degradation pathway that is responsible for increasing amounts of free acids in storage, especially upon exposure to moisture.

Inkompatibilit?ten

Hypromellose acetate succinate is incompatible with strong acids or bases, oxidizing agents, and sustained levels of elevated humidity.

Regulatory Status

Included in the FDA Inactive Ingredients Database for use in oral preparations (capsules, and delayed-action preparations). Hypromellose acetate succinate has been approved for use in commercial pharmaceutical products in the USA and in Japan.

HYDROXYPROPYL METHYL CELLULOSE ACETATE SUCCINATE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


HYDROXYPROPYL METHYL CELLULOSE ACETATE SUCCINATE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 96)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12835 58
Hebei Weibang Biotechnology Co., Ltd
+8617732866630
bess@weibangbio.com China 18155 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21638 55
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22963 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
Hebei Zhanyao Biotechnology Co. Ltd
15369953316 +8615369953316
admin@zhanyaobio.com China 2123 58
ANHUI WITOP BIOTECH CO., LTD
+8615255079626
eric@witopchemical.com China 23541 58
Wuhan Fortuna Chemical Co., Ltd
+86-027-59207850
info@fortunachem.com China 5986 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739
info@dycnchem.com China 52849 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418684 +8618949823763
sales@tnjchem.com China 25356 58

71138-97-1()Verwandte Suche:


  • Cellulose,2-hydroxypropylmethylehter,acetatehydrogenbutanedioate
  • HYDROXYPROPYL METHYL CELLULOSE ACETATE SUCCINATE
  • Hypromellose Acetate Succinate (100 mg)
  • Hydroxypropyl Methyl cellulose acetate succinate JPE
  • 2-hydroxypropylmethylehter,acetatehydrogenbutanedioate
  • Hypromellose Acetate Succinate (1335279)
  • acetic acid, methanol
  • HYDROXYPROPYL METHYL CELLULOSE ACETATE SUCCINATE,(HPMCAS)
  • acetic acid, methanol, propane-1,2-diol, succinic acid
  • HPMCAS
  • HyproMellose Acetate Succinate
  • Acetate hydroxypropyl methylcellulose succinate
  • Cellulose 2-Hydroxypropylmethyl Ether Esterified with Acetate Esterified Succinic Acid Hydrogen Esterification
  • HPMCAS AS-MF
  • 71138-97-1
  • C10H22O9
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