EI1
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- CAS-Nr.
- 1418308-27-6
- Englisch Name:
- EI1
- Synonyma:
- EI1;CS-2378;EI1;EI 1;KB-145943;EI1 USP/EP/BP;EI1;EI-1;EI 1;EI1 (KB145943;Ezh2 inhibitor;EI1 (Ezh2 inhibitor;Histone Methyltransferase,Inhibitor,inhibit,Apoptosis,EI-1,EI1,KB145943,EI 1,KB 145943
- CBNumber:
- CB52655403
- Summenformel:
- C23H26N4O2
- Molgewicht:
- 390.48
- MOL-Datei:
- 1418308-27-6.mol
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EI1 Eigenschaften
- Siedepunkt:
- 675.9±55.0 °C(Predicted)
- Dichte
- 1.20±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- L?slichkeit
- insoluble in H2O; insoluble in EtOH; ≥19.5 mg/mL in DMSO
- Aggregatzustand
- Powder
- pka
- 11.88±0.10(Predicted)
- Farbe
- White to off-white
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
EI1 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
EZH2 is a histone methyltransferase and its activation leads to alteration in cell cycle regulation, proliferation, and cancer progression [65]. High expression and mutation of EZH2 are in a variety of malignancies and usually portend for
a poor prognosis.
Pharmakologie
EZH2 has been shown to repress the cell cycle inhibitor p21 and other proapoptotic factors, thereby promoting cell cycling in SCLC cells. In various
SCLC cell lines, suppression of EZH2 leads to reduction of cells in S, G2/M phase
with increased p21 expression. EZH2 was also shown to prevent apoptosis by
inhibition of TGF-β via histone methyltransferase methylation of lysine 27?in histone H3 (H3K27me3). In addition, it has been shown that in platinum-resistant cancer cells, protein and mRNA expression EZH2 is upregulated and by
silencing EZH2 overcomes drug resistance, making EZH2 a target of interest in SCLC.
EI1 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
EI1 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 72)Lieferanten
1418308-27-6()Verwandte Suche:
- EI1
- Ezh2 inhibitor
- 6-Cyano-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-1-(1-ethylpropyl)-1H-indole-4-carboxamide
- EI1;EI-1;EI 1
- 6-cyano-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-(pentan-3-yl)-1H-indole-4-carboxamide
- CS-2378
- EI1 (Ezh2 inhibitor
- EI1;EI 1
- KB-145943
- 1H-Indole-4-carboxamide, 6-cyano-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-1-(1-ethylpropyl)-
- EI1 USP/EP/BP
- EI1 (KB145943
- Histone Methyltransferase,Inhibitor,inhibit,Apoptosis,EI-1,EI1,KB145943,EI 1,KB 145943
- 1418308-27-6
- Inhibitors
- API
