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Alpelisib (BYL719)

Alpelisib (BYL719) Struktur
1217486-61-7
CAS-Nr.
1217486-61-7
Englisch Name:
Alpelisib (BYL719)
Synonyma:
Alpelisib;Piqray;BYL-719;CS-614;100803;BLV-719;BYL-719 /BYL719;Alpelisib (BYL719);BYL-719(Alpelisib);Alpelisib (BLY-719
CBNumber:
CB52604234
Summenformel:
C19H22F3N5O2S
Molgewicht:
441.47
MOL-Datei:
1217486-61-7.mol

Alpelisib (BYL719) Eigenschaften

Dichte
1.391
storage temp. 
Store at -20°C
L?slichkeit
≥22.07 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
Aggregatzustand
White solid.
pka
6.29±0.70(Predicted)
Farbe
Off-white to light yellow
InChIKey
STUWGJZDJHPWGZ-LBPRGKRZSA-N
SMILES
N1(C(NC2=NC(C)=C(C3C=CN=C(C(C)(C)C(F)(F)F)C=3)S2)=O)CCC[C@H]1C(N)=O
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
HS Code  29341000
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H373 Kann die Organe sch?digen bei l?ngerer oder wiederholter Exposition. Spezifische Zielorgan-Toxizit?t (wiederholte Exposition) Kategorie 2 Warnung P260, P314, P501
Sicherheit
P260 Dampf/Aerosol/Nebel nicht einatmen.
P314 Bei Unwohlsein ?rztlichen Rat einholen / ?rztliche Hilfe hinzuziehen.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Alpelisib (BYL719) Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

BYL719 is an inhibitor of phosphoinositide 3-kinase α (PI3Kα; IC50s = 4.6, 4, and 4.8 nM for wild-type, E545K mutant, and H1047R mutant PI3K, respectively). It is selective for PI3Kα over PI3Kβ, PI3Kδ, PI3Kγ, and PI4Kβ (IC50s = 1,156, 290, 250, and 581 nM, respectively), as well as VPS34, mTOR, DNA-PK, and ATR (IC50s = >9,100 nM for all). BYL719 (12.5, 25, and 50 mg/kg) reduces tumor volume in a PI3Kα-dependent Rat1-myr-p110α mouse xenograft model. It also reduces tumor burden in THP-1 acute myeloid leukemia (AML) and MCF-7 breast cancer mouse xenograft models. Formulations containing BYL719 have been used in the treatment of advanced or metastatic breast cancer.

Trademarks

Piqray

Alpelisib (BYL719) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Acetamide,N-[4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]- 4-Methyl-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine 4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine 4-methyl-2-(2,2,2-trifluoro-1-methyl-1-trimethylsilanyloxy-ethyl)pyridine 1,1,1-trifluoro-2-(4-methylpyridin-2-yl)propan-2-ol 1,1,1-trifluoro-2-(4-methylpyridin-2-yl)propan-2-yl methanesulfonate N-(4-Methyl-5-(2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)-1H-iMidazole-1-carboxaMide phenyl 4-methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-ylcarbamate (S)-Pyrrolidin-2-carboxamid 1-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)propan-2-one 2-Acetyl-4-methylpyridine 2,4-Dimethylpyridin

Downstream Produkte

Alpelisib (BYL719) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 221)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Wuhan Fortuna Chemical Co., Ltd 		+86-027-59207850
info@fortunachem.com China 5986 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8617865335152
 Mandy@hangyubiotech.com China 10986 58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. 		+86-18600796368 +86-18600796368
 sales@sjar-tech.com China 375 58
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714
 fandachem@gmail.com China 9220 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32820 60
career henan chemical co 		+86-0371-86658258 +8613203830695
 sales@coreychem.com China 29886 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254
linda@hubeijusheng.com CHINA 28172 58
BOC Sciences 		+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873
 sales@chemdad.com China 39894 58
Xi'an Yutbon Pharmaceutical Technology Co., Ltd 		029-81140587 +8618717328141
 sales@yutbon.com China 454 58

1217486-61-7()Verwandte Suche:

  • (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide
  • BYL-719 /BYL719
  • BLV-719
  • (S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxaMide
  • 1,2-Pyrrolidinedicarboxamide, N1-[4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-, (2S)-
  • Alpelisib (BYL719)
  • (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide BYL-719
  • BYL-719 (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide
  • BYL-719(Alpelisib)
  • (S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)-pyridin-4-yl)thiazol-2-yl)pyrrolid
  • ALPELISIB;BYL-719; BYL 719
  • CS-614
  • Alpelisib - NVP-BYL719 | BYL-719
  • 100803
  • (2S)-1-N-[4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide
  • Alpelisib, 98%, a potent and selective PI3Kα inhibitor
  • (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide ISO 9001：2015 REACH
  • Alpelisib (BLY-719
  • (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidine
  • BYL-719
  • Alpelisib
  • Piqray
  • Inhibitor,Phosphoinositide 3-kinase,PI3K,Alpelisib,inhibit,phosphorylation,p110α,cancer,BYL 719,antineoplastic,AKT,metastasis,mutant,BYL719,PIK3CA,breast
  • Biopterin Impurity 2
  • (2S) - N1- [4-methyl-5- [2- (2,2,2-trifluoro-1,1-dimethylethyl) -4-pyridyl] -2-thiazolyl] -1,2-pyrrolidine dicarboxylamide
  • 1217486-61-7
  • C19H22F3N5O2S
  • Inhibitors
  • Akt
  • mTOR
  • PI3K
  • PI3K/Akt/mTOR
  • Api
  • API
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