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2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one

2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one Struktur
5291-32-7
CAS-Nr.
5291-32-7
Englisch Name:
2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one
Synonyma:
PRIMA-1MET;APR-246;Eprenetapopt;APR246;APR 246;PRIMA-1MET(APR-246);APR-246 (PRIMA-1MET);Eprenetapopt (APR246;PRIMA-1MET;2-(Hydroxymethyl)-2-(methoxymethyl)-3-quinuclidinone;2-(Hydroxymethyl)-2-(methoxymethyl)quinuclidin-3-one
CBNumber:
CB52518928
Summenformel:
C10H17NO3
Molgewicht:
199.25
MOL-Datei:
5291-32-7.mol

2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one Eigenschaften

Schmelzpunkt:
115-116 °C
Siedepunkt:
313.8±17.0 °C(Predicted)
Dichte
1.20±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
L?slichkeit
Soluble in DMSO (up to 20 mg/ml)
Aggregatzustand
powder
pka
13.99±0.10(Predicted)
Farbe
white to beige
Stabilit?t:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

2-(Hydroxymethyl)-2-(methoxymethyl)quinuclidin-3-one is a small molecule that has shown promising preclinical activity in various cancer types. 2-(Hydroxymethyl)-2-(methoxymethyl)quinuclidin-3-one shows antitumor activity in multiple myeloma by induction of p73 and Noxa.

Biochem/physiol Actions

PRIMA-1Met, also called APR-246, is converted to methylene quinuclidinone (MQ), a Michael acceptor. It interacts with p53 through the cysteine (Cys) residue. It blocks the thioredoxin reductase (TrxR1) enzyme. It is under clinical investigation and well-studied. PRIMA-1Met effect is tested on breast cancer specific gene expression.

2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 103)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
bruce@xrdchem.cn CHINA 566 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32957 60
Career Henan Chemica Co
+86-0371-86658258 +8613203830695
laboratory@coreychem.com China 30239 58
Chemia Biotechnology(Shanghai) Co., Ltd
+8613816753574
info@chemia-pharm.com CHINA 311 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471
sales@sarms4muscle.com China 10473 58
InvivoChem
+1-708-310-1919 +1-13798911105
sales@invivochem.cn United States 6391 58
Nantong HI-FUTURE Biology Co., Ltd.
+undefined18051384581
sales@chemhifuture.com China 3135 58
TargetMol Chemicals Inc.

support@targetmol.com United States 38631 58
Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525
masar@topule.com China 8467 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58

  • 2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one
  • APR-246
  • PRIMA-1MET
  • 2-(Hydroxymethyl)-2-(methoxymethyl)quinuclidin-3-one
  • 1-Azabicyclo[2.2.2]octan-3-one, 2-(hydroxymethyl)-2-(methoxymethyl)-
  • 2-(Hydroxymethyl)-2-(methoxymethyl)-3-quinuclidinone
  • PRIMA-1MET 2-(Hydroxymethyl)-2-(methoxymethyl)quinuclidin-3-one 2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one APR-246
  • APR246;APR 246
  • PRIMA-1MET(APR-246)
  • APR-246 (PRIMA-1MET)
  • PRIMA-1MET
  • Eprenetapopt
  • Eprenetapopt (APR246
  • 5291-32-7
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