Diclofenac
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Diclofenac Eigenschaften
- Schmelzpunkt:
- 156-158°
- Siedepunkt:
- 412.0±45.0 °C(Predicted)
- Dichte
- 1.431±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- L?slichkeit
- soluble in Methanol
- Aggregatzustand
- powder to crystal
- pka
- pKa 4 (Uncertain)
- Farbe
- White to Almost white
- Wasserl?slichkeit
- 1.278mg/L(30 ºC)
- Merck
- 14,3081
- InChIKey
- DCOPUUMXTXDBNB-UHFFFAOYSA-N
- CAS Datenbank
- 15307-86-5(CAS DataBase Reference)
- NIST chemische Informationen
- Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-(15307-86-5)
- EPA chemische Informationen
- Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]- (15307-86-5)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
RIDADR | 3249 | ||
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RTECS-Nr. | AG6310000 | ||
HS Code | 2922.49.2600 | ||
HazardClass | 6.1(b) | ||
PackingGroup | III | ||
Giftige Stoffe Daten | 15307-86-5(Hazardous Substances Data) |
Bildanzeige (GHS) |
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Sicherheit |
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Diclofenac Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
prostaglandin synthetic inhibitorIndications
Diclofenac (Voltaren, Cataflam) is approved for use in rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, dysmenorrhea, and topically for the treatment treatment of ocular inflammation and actinic keratosis. Diclofenac exhibits approximately equal selectivity for COX-1 and COX-2. The most common adverse reactions are GI disturbances and headache.A reversible elevation of serum transaminases occurs in 15% of patients.Biologische Funktion
Diclofenac (Voltaren) is a phenylacetic acid derivative that is a potent inhibitor of COX and that has analgesic, antiinflammatory, and antipyretic effects. Its use is accompanied by side effects similar to those of other NSAIDs. Indications for the drug include rheumatoid arthritis, osteoarthritis, and ophthalmic inflammation (use of an ophthalmic preparation).Mechanism of action
Diclofenac is unique among the NSAIDs in that it possesses three possible mechanisms of action: 1) inhibition of the arachidonic acid cyclooxygenase system (3 to 1,000 times more potent than other NSAIDs on a molar basis), resulting in a decreased production of prostaglandins and thromboxanes; 2) inhibition of the lipoxygenase pathway, resulting in decreased production of leukotrienes, particularly the pro-inflammatory LKB4; and 3) inhibition of arachidonic acid release and stimulation of its reuptake, resulting in a reduction of arachidonic acid availability.Pharmakokinetik
Diclofenac is rapidly and completely (~100%) absorbed on oral administration, with peak plasma levels being reached within 1.5 to 2.5 hours. The free acid (pKa = 4.0) is highly bound to serum proteins (99.5%), primarily albumin. Only 50 to 60% of an oral dose is bioavailable because of extensive hepatic metabolism.Clinical Use
Diclofenac is synthesized from N-phenyl-2,6-dichloroaniline. It is available in 120 different countries and, perhaps, is the most widely used NSAID in the world. It was introduced in the United States in 1989 but was first marketed in Japan in 1974. It ranks among the top prescription drugs in the United States. Diclofenac possesses structural characteristics of both arylalkanoic acid and the anthranilic acid classes of anti-inflammatory drugs, and it displays anti-inflammatory, analgetic, and antipyretic properties.Stoffwechsel
Four major metabolites resulting from aromatic hydroxylation have been identified. The major metabolite via CYP3A4 is the 4′-hydroxy derivative and accounts for 20 to 30% of the dose excreted, whereas the 5-hydroxy, 3′-hydroxy, and 4′,5-dihydroxy metabolites via CYP2C9 account for 10 to 20% of the excreted dose. The remaining drug is excreted in the form of sulfate conjugates. Although the major metabolite is much less active than the parent compound, it may exhibit significant biological activity, because it accounts for 30 to 40% of all of the metabolic products.Diclofenac Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Diclofenac Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 429)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
Hebei Mujin Biotechnology Co.,Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12825 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5878 | 58 |
Anhui Ruihan Technology Co., Ltd | +8617756083858 |
daisy@anhuiruihan.com | China | 973 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20255 | 58 |
Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 |
admin@zlchemi.com | China | 3692 | 58 |
Hebei Shengyang Water Conservancy Engineering Co., Ltd. | +8615373025980 |
clara@hbshengyang.com | China | 896 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21631 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29865 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28172 | 58 |
Hebei Chuanghai Biotechnology Co., Ltd | +86-15531157085 +86-15531157085 |
abby@chuanghaibio.com | China | 8805 | 58 |
15307-86-5(Diclofenac)Verwandte Suche:
Phenylvalerat
Dichlor(methyl)(phenyl)silan
Phenylphosphonsaeuredichlorid
Phenylsalicylat
Diphenylether
α-Phenylglycin
o-Hydroxyphenylessigsure
(o-(-2,6-Dichloranilino)phenyl)-essigs?ure, Natrium-Salz
3,4'-DIAMINODIPHENYLMETHANE
ACETIC ACID
PHENYL RESIN
Phenylessigsure
2,6-dichlor-N-phenylanilin
Diclofenac diethylamine
Diclofenac potassium
Essigs?ureanhydrid
Mechitazin
Apfelsure, Verbindung mit 4-(9,10-Dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-yliden)-1-methylpiperidin (1:1)
- 1-(2,6-DICHLOROPHENYL)-1,3-DIHYDRO-INDOLE-2-ONE
- (N-1-(2,6-DICHLOROPHENYL) -2-INDOLIN-2-ONE
- 2-[[2,6-Dichlorophenyl] amino] benzeneacetic acid
- 1-(2,6-DICHLOROPHENYL)-2-INDOLINONE /MEQUITAZINE
- 1-(2,6-DICHLOROPHENYL)-2-INDOLINONE/INDOLINONE
- DICLOFENAC ACID/[2-(2,6-DICHLORO-PHENYLAMINO)-PHENY]-ACETIC ACID
- (o-(2,6-dichloroanilino)phenyl)-acetic acid
- [2-(2,6-Dichloroanilino)phenyl]-acetic acid
- 2-[2-(2,6-Dichlorophenyl)aminophenyl]ethanoic acid
- SodiuM2-[2-[(2-BroMo-6-chlorophenyl)aMino]phenyl]acetate
- IMp. D (EP) as SodiuM Salt: SodiuM 2-[2-[(2-BroMo-6-chlorophenyl)aMino]phenyl]acetate
- IMp. D (EP): 2-[2-[(2-BroMo-6-chlorophenyl)aMino]phenyl]acetic Acid
- Rhumalgan
- 2-(2-(2,6-dichlorophenylamino)phenyl)acetic acid
- [2-[(2,6-Dichlorophenyl)aMino]phenyl]-Methanol (Diclofenac alcohol)
- 2-[(2,6-Dichlorophenyl)aMino]benzaldehyde (Diclofenac aldehyde)
- 2-[2-[(2-broMo-6-chlorophenyl)aMino]phenyl]acetic acid
- Diclac
- DiclofenaMic acid
- DicloMelan
- DicloreuMa
- Transfenac
- Voltaflan
- Aceclofenac IMpurity-A(EP/BP)
- Diclofenac SodiuM IMp. D (EP)
- Diclofenac acid Solution, 100ppm
- Diciofenac solution,100ppm
- Benzeneacetic acid,2-[(2,6-dichlorophenyl)aMino]-
- 1-(2,6-Dichlorophenyl)-2-indolinone, 99%, 99%
- Diclofenac aci
- 2-[(2,6-Dichlorophenyl)amino]phenyl-acetic acid
- Aceclofenac EP impurity-A(Diclofenac)
- 2-(2,6-Dichloroanilino)phenylaceticAcid>
- Diclofenacum
- 1-(2,6-Dichlorophenyl)-2-indolinone USP/EP/BP
- Diclofenac D6
- DiclofenacQ: What is Diclofenac Q: What is the CAS Number of Diclofenac Q: What is the storage condition of Diclofenac
- Dielofenac
- Diclofenac Free Base
- 2-(2,6-dichloroanilino)-2-phenylacetic acid
- Diclofenac(2-(2,6-Dichloroanilino)phenylacetic Acid)
- Diciofenac
- dichlofenac
- Diclofenac
- Pennsaid
- DICLOFENAC FREE ACID
- Dichlofenac acid
- Diclofenac (Aceclofenac EP Impurity A)
- iclofenac
- Epolamine Impurity-4
- DICLOFENAC SODIUM 30% SR, 33% SR, 40% SR PELLETS
- Diclofenac in methanol
- C12537000 DiclofenaCacid
- Diclofenac, 10 mM in DMSO
- 15307-86-5
- 5307-86-5
- 15362-40-4
- 16362-40-0