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[(2R)-1-[(2S)-2-Amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid mesylate

[(2R)-1-[(2S)-2-Amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid mesylate Struktur
150080-09-4
CAS-Nr.
150080-09-4
Englisch Name:
[(2R)-1-[(2S)-2-Amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid mesylate
Synonyma:
CS-1219;PT100 mesylate;Unii-V8zg4Y1B51;Talabostat Mesilate;Talabostat mesylate;Val-boroPro mesylate;Adrafinil Impurity 6;Talabostat-mesylate, PT-100;[(2R)-1-(L-Valyl)-2-pyrrolidinyl]boronic acid methanesulfonate (1:1);[(2R)-1-[(2S)-2-Amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid mesylate
CBNumber:
CB52128758
Summenformel:
C10H23BN2O6S
Molgewicht:
310.17
MOL-Datei:
150080-09-4.mol

[(2R)-1-[(2S)-2-Amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid mesylate Eigenschaften

Schmelzpunkt:
>160°C (dec.)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
L?slichkeit
Soluble in DMSO (up to at least 25 mg/ml)
Aggregatzustand
solid
Farbe
White
Stabilit?t:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Sicherheit

[(2R)-1-[(2S)-2-Amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid mesylate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Talabostat is a non-selective inhibitor of dipeptidyl peptidases (DPPs), including DPP-4, DPP-7, DPP-8, DPP-9, fibroblast activation protein (FAP), and prolyl endopeptidase (PREP; IC50s = >4, 310, 4, 11, 560, and 390 nM, respectively). It inhibits proliferation of superantigen-stimulated human peripheral blood mononuclear cells (PBMCs; IC50 = ~10 nM). Talabostat (5 μg twice per day) increases expression of a variety of cytokines, including those encoding IL-1β, IL-6, and G-CSF, and chemokines in tumors and tumor-draining lymph nodes in a WEHI-164 fibrosarcoma mouse model. It reduces tumor growth in WEHI-164, MM45T.Sp, and MM52.T fibrosarcoma, EL-4 and A20/2J lymphoma, B16/F10 melanoma, and P815 mastocytoma syngeneic mouse models. Talabostat also increases the efficacy of the antitumor antibodies rituximab and trastuzumab in Namalwa B cell lymphoma and LS180 colon carcinoma mouse xenograft models, respectively.

Verwenden

Treatment of cancer; hematopoetic stimulant.

Biochem/physiol Actions

Cell permeable: yes

[(2R)-1-[(2S)-2-Amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid mesylate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


[(2R)-1-[(2S)-2-Amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid mesylate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 109)Lieferanten
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150080-09-4()Verwandte Suche:


  • [(2R)-1-[(2S)-2-Amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid mesylate
  • Boronic acid, ((2R)-1-((2S)-2-amino-3-methyl-1-oxobutyl)-2-pyrrolidinyl)-, monomethanesulfonate
  • Unii-V8zg4Y1B51
  • Methanesulfonic acid ((R)-1-((S)-2-amino-3-methyl-butanoyl)pyrrolidin-2-yl)boronic acid (1:1)
  • Talabostat mesylate
  • Talabostat Mesilate
  • [(2R)-1-[(2S)-2-Amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid mesylate Talabostat mesilate
  • Talabostat mesylate [(2R)-1-[(2S)-2-Amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid mesylate
  • [(2R)-1-(L-Valyl)-2-pyrrolidinyl]boronic acid methanesulfonate (1:1)
  • [(2R)-1-[(2S)-2-Amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid mesylate ISO 9001:2015 REACH
  • (2R)-1-[(2S)-2-amino-3-methylbutanoyl]pyrrolidin-2-yl]boronicacid,methanesulfonicaci
  • PT100 mesylate
  • B-[(2R)-1-[(2S)-2-Amino-3-methyl-1-oxobutyl]-2-pyrrolidinyl]boronic acid methanesulfonate
  • Talabostat-mesylate, PT-100
  • CS-1219
  • Val-boroPro mesylate
  • [(2R)-1-[(2S)-2-amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid,methanesulfonic acid
  • (R)-1-[(S)-2-Amino-3-methylbutanoyl]pyrrolidine-2-boronic Acid Methanesulfonate
  • methanesulfonic acid compound with ((R)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-yl)boronic acid (1:1)
  • Adrafinil Impurity 6
  • 150080-09-4
  • C10H23BN2O6S
  • C9H19BN2O3CH4O3S
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