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Naftifine

Naftifine Struktur
65472-88-0
CAS-Nr.
65472-88-0
Englisch Name:
Naftifine
Synonyma:
Naftin;naftifin;Exoderil;NAFTIFINE;AW-105-843;SN-105-843;Naftifungin;Naftifine D3;Naftifinebase;Naftifine 13CD3
CBNumber:
CB5211922
Summenformel:
C21H21N
Molgewicht:
287.4
MOL-Datei:
65472-88-0.mol

Naftifine Eigenschaften

Schmelzpunkt:
177 °C
Siedepunkt:
bp0.015 torr 162-167°
Dichte
1.082±0.06 g/cm3(Predicted)
L?slichkeit
Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Very Slightly)
Aggregatzustand
Thick Oil
pka
7.99±0.50(Predicted)
Farbe
Colourless to Dark Yellow
Merck 
6355
CAS Datenbank
65472-88-0(CAS DataBase Reference)

Sicherheit

HS Code  29214990

Naftifine Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Naftifine (Naftin) is a synthetic allylamine derivative topical antifungal agent that works by blocking squalene 2,3-epoxidase, resulting in increased cell membrane permeability and cell death. It is structurally and pharmacologically related to terbinafine. It also has some antiinflammatory properties that may be due to its ability to alter chemotaxis by polymorphonucleocytes. It is most effective against dermatophytes, moderately active against molds, and less active against yeasts, including C. albicans.

Indications

Naftifine (Naftin) is a synthetic allylamine derivative topical antifungal agent that works by blocking squalene 2,3-epoxidase, resulting in increased cell membrane permeability and cell death. It is structurally and pharmacologically related to terbinafine. It also has some antiinflammatory properties that may be due to its ability to alter chemotaxis by polymorphonucleocytes. It is most effective against dermatophytes, moderately active against molds, and less active against yeasts, including C. albicans.

Definition

ChEBI: A tertiary amine in which the nitrogen is substituted by methyl, alpha-naphthylmethyl, and (1E)-cinnamyl groups. It is used (usually as its hydrochloride salt) for the treatment of fungal skin infections.

Antimicrobial activity

Naftifine is fungicidal against dermatophytes such as Epidermophyton floccosum, Trichophyton and Microsporum species. Against pathogenic yeasts such as Candida species and moulds, it shows only an intermediate fungistatic activity in vitro.

Pharmazeutische Anwendungen

A topical antifungal used as a 1% cream for the treatment of dermatophytoses, including tinea pedis, tinea corporis and tinea cruris.

Clinical Use

Naftifine was the first allyl amine to be discovered and marketed. It is subject to extensive first-pass metabolism to be orally active and, consequently, is only available in topical preparations. The widest use of naftifine is against various tinea infections of the skin.

Naftifine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Naftifine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 77)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29811 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 22784 58
AFINE CHEMICALS LIMITED
+86-0571-85134551
sales@afinechem.com China 15352 58
Hebei Fengjia New Material Co., Ltd
+86-0311-87836622 +86-17333973358
sales06@hbduling.cn China 8051 58
GIHI CHEMICALS CO.,LIMITED
+8618058761490
info@gihichemicals.com China 49978 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652
info@fdachem.com China 20284 58
SHANGHAI KEAN TECHNOLOGY CO., LTD.
+8613817748580
cooperation@kean-chem.com China 40066 58
Amadis Chemical Company Limited
571-89925085
sales@amadischem.com China 131957 58
Mainchem Co., Ltd. +86-0592-6210733
sale@mainchem.com China 32343 55
Chemwill Asia Co.,Ltd. 86-21-51086038
chemwill_asia@126.com CHINA 23912 58

65472-88-0()Verwandte Suche:


  • naftifin
  • n-trans-cinnamyl-n-methyl-(1-naphthylmethyl)amine
  • NAFTIFINE
  • (e)-n-methyl-n-(1-naphthyl methyl)-3-phenyl-2-propen-1-amine
  • AW-105-843
  • Exoderil
  • Naftifungin
  • Naftin
  • SN-105-843
  • N-[(E)-3-Phenyl-2-propenyl]-N-methylnaphthalene-1-methanamine
  • N-Methyl-N-[(E)-3-phenyl-2-propenyl]-1-naphthalenemethanamine
  • (E)-N-methyl-N-(naphthalen-1-ylmethyl)-3-phenyl-prop-2-en-1-amine
  • (E)-N-methyl-N-(naphthalen-1-ylmethyl)-3-phenylprop-2-en-1-amine
  • METHYL-NAPHTHALEN-1-YLMETHYL-((E)-3-PHENYL-ALLYL)-AMINE
  • Naftifinebase
  • N-TRANS-CINNAMYL-N-METHYL-(1-NAPPHTHYLMETHYL)AMINE HYDROCHLORIDE
  • (E)-N-Methyl-N-(3-phenyl-2-propenyl)-1-naphthalenemethanamine
  • methyl-(1-naphthylmethyl)-[(E)-3-phenylallyl]amine
  • 1-NaphthaleneMethanaMine,N-Methyl-N-[(2E)-3-phenyl-2-propen-1-yl]-
  • N-trans-Cinnamyl-N-methyl-(1-naphthylmethyl)amine Hydrochloride, ≥ 98.0%
  • Naftifine USP/EP/BP
  • Naftifine 13CD3
  • Naftifine D3
  • 65472-88-0
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