Anti-UV radiation resistance-associated gene Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Anti-UVRAG antibody produced in rabbit has been used:
- in western blotting
- in immunofluorescence
Allgemeine Beschreibung
Ultraviolet irradiation resistance-associated gene (UVRAG) is an important autophagic tumor suppressor, encoded by the gene mapped to human chromosome 11q13.5. The encoded protein is characterized with four functional domains, such as proline-rich domain, a lipid-binding C2 domain, a beclin1-binding coiled-coil domain (CCD) and a C-terminal domain involved in centrosome integrity and DNA damage repair.
Biochem/physiol Actions
Ultraviolet irradiation resistance-associated gene (UVRAG) is implicated in the regulation of intracellular membrane trafficking, including autophagy and chromosomal stability. The encoded protein regulates apoptosis by suppressing the BCL2-associated X protein (Bax) activity. Mutation in the gene has been observed in various types of human cancers, including microsatellite unstable colon carcinomas.
Anti-UV radiation resistance-associated gene Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
