LY 367385 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
LY 367385 is a selective mGlu1a receptor antagonist used to treat inflammatory diseases (ie. multiple sclerosis) and neurodegenerative diseases (ie. Alzheimer’s) (1,2).
Biologische Aktivit?t
A selective mGlu 1a receptor antagonist, with an IC 50 value of 8.8 μ M for blockade of quisqualate-induced phosphoinositide hydrolysis vs. > 100 μ M for mGlu 5a , and negligible action on group II and III receptors. Also available as part of the Group I mGlu Receptor Tocriset™ .
Biochem/physiol Actions
LY-367385 hydrochloride has an ability to inhibit induction of long-term potentiation (LTP).
LY 367385 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte