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[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol

[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Struktur
5428-80-8
CAS-Nr.
5428-80-8
Englisch Name:
[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol
Synonyma:
Vacquinol-1;CS-2185;NSC13316;NSC-13316;NSC 13316;Vacquinol-1（NSC13316）;NSC 13316;NSC13316;NSC-13316;VACQUINOL 1;VACQUINOL1;4-Quinolinemethanol,2-(4-chlorophenyl)-a-2-piperidinyl-;[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol;4-Quinolinemethanol, 2-(4-chlorophenyl)-α-2-piperidinyl-
CBNumber:
CB51254607
Summenformel:
C21H21ClN2O
Molgewicht:
352.86
MOL-Datei:
5428-80-8.mol

[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Eigenschaften

Schmelzpunkt:
198-199.5 °C
Siedepunkt:
551.4±50.0 °C(Predicted)
Dichte
1.244±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
DMF: 10 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 1 mg/ml; Ethanol: 0.25 mg/ml
Aggregatzustand
A crystalline solid
pka
13.22±0.20(Predicted)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
HS Code  2933499090
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H317 Kann allergische Hautreaktionen verursachen. Sensibilisierung der Haut Kategorie 1A Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Vacquinols are a new class of quinine-derivatives that stimulate death in glioblastoma cells by massive macropinocytotic vacuolization, ATP depletion, and cytoplasmic membrane rupture. A key effector of vacquinols is MAPK kinase 4 (MKK4). Vacquinol-1 is an activator of MKK4-dependent macropinocytotic cell death in glioblastoma cells. It induces ATP depletion in glioblastoma cells (IC50 = 3.14 μM at 1 day) without affecting fibroblasts, embryonic stem cells, or osteosarcoma cells. Vacquinol-1 is orally bioavailable with good brain penetrance and excellent pharmacokinetics. Oral administration of vacquinol-1 (20 mg/kg once daily for five days) substantially impairs the growth of engrafted glioblastoma cell tumors in mice and prolongs survival.

Verwenden

Vacquinol-1 is in the vacquinol class of quinine derivatives that stimulate death in glioblastoma cells through massive macropinocytotic vacuolization, ATP depletion and eventual cytoplasmic membrane rupture.

[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 73)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
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career henan chemical co 		+86-0371-86658258 +8613203830695
 factory@coreychem.com China 29811 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
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InvivoChem 		+1-708-310-1919 +1-13798911105
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TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054
 trendseenbio@gmail.com China 11681 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525
 masar@topule.com China 8467 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		+86-18341751992 +86-15382112998
 757984502@qq.com China 892 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+undefined18621343501
 product@acmec-e.com China 33338 58
  • [2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol
  • 4-Quinolinemethanol,2-(4-chlorophenyl)-a-2-piperidinyl-
  • NSC 13316
  • NSC 13316;NSC13316;NSC-13316;VACQUINOL 1;VACQUINOL1
  • NSC13316
  • NSC-13316
  • CS-2185
  • 4-Quinolinemethanol, 2-(4-chlorophenyl)-α-2-piperidinyl-
  • Vacquinol-1
  • Vacquinol-1（NSC13316）
  • 5428-80-8
  • C21H23Cl3N2O
  • building block
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