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Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)-

Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)- Struktur
170858-33-0
CAS-Nr.
170858-33-0
Englisch Name:
Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)-
Synonyma:
U 101387;PNU 101387;PF-05191680;PNU-101387G;Sonepiprazole;Sonepiprazole hydrate;Sonepiprazole, 10 mM in DMSO;inhibit,Dopamine Receptor,U-101387G,Sonepiprazole,PNU-101387G,Inhibitor;4-[4-[2-[(1S)-Isochroman-1-yl]ethyl]piperazin-1-yl]benzenesulfonamide hydrate;(S)-4-[4-[2-(3,4-Dihydro-1H-2-benzopyran-1-yl)ethyl]-1-piperazinyl]benzenesulfonaMide
CBNumber:
CB51245409
Summenformel:
C21H27N3O3S
Molgewicht:
401.52
MOL-Datei:
170858-33-0.mol

Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)- Eigenschaften

storage temp. 
room temp
L?slichkeit
DMSO: >10mg/mL
Aggregatzustand
powder
Farbe
white to off-white

Sicherheit

WGK Germany  3

Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)- Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Sonepiprazole is a selective antagonist of the dopamine 4 (D4) receptor (Kis = 10 nM). It is highly selective over D1, D2, and D3 receptors, serotonin 1A and 2 receptors, as well as α1- and α2-adrenergic receptors (Kis > 2,000 nM). Its safety profile in rat studies is improved in comparison to classical antipsychotics but it is not effective for positive or negative symptoms of schizophrenia in patients. In a pharmacological model of stress exposure in rhesus monkeys, sonepiprazole reverses stress-induced cognitive deficits.

Verwenden

Sonepiprazole is a dopamine D4 antagonist with Ki=10 nM.

Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)- Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)- Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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  • (S)-4-[4-[2-(3,4-Dihydro-1H-2-benzopyran-1-yl)ethyl]-1-piperazinyl]benzenesulfonaMide
  • 4-[4-[2-[(1S)-3,4-Dihydro-1H-2-benzopyran-1-yl]ethyl]-1-piperazinyl]benzenesulfonaMide
  • PF-05191680
  • PNU 101387
  • Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)-
  • U 101387
  • Sonepiprazole
  • 4-[4-[2-[(1S)-Isochroman-1-yl]ethyl]piperazin-1-yl]benzenesulfonamide hydrate
  • PNU-101387G
  • Sonepiprazole hydrate
  • Benzenesulfonamide, 4-[4-[2-[(1S)-3,4-dihydro-1H-2-benzopyran-1-yl]ethyl]-1-piperazinyl]-
  • inhibit,Dopamine Receptor,U-101387G,Sonepiprazole,PNU-101387G,Inhibitor
  • Sonepiprazole, 10 mM in DMSO
  • 170858-33-0
  • 70858-33-0
  • Aromatics
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pfizer Compounds
  • Pharmaceuticals
  • Sulfur & Selenium Compounds
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