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1-(2-Chlorethyl)-3-cyclohexyl-1-nitrosoharnstoff

Lomustine Struktur
13010-47-4
CAS-Nr.
13010-47-4
Bezeichnung:
1-(2-Chlorethyl)-3-cyclohexyl-1-nitrosoharnstoff
Englisch Name:
Lomustine
Synonyma:
cinu;CCNU;ceenu;rb1509;cecenu;sri2200;nsc79037;icig1109;Lomustin;belustine
CBNumber:
CB5123021
Summenformel:
C9H16ClN3O2
Molgewicht:
233.7
MOL-Datei:
13010-47-4.mol

1-(2-Chlorethyl)-3-cyclohexyl-1-nitrosoharnstoff Eigenschaften

Schmelzpunkt:
88-90
Siedepunkt:
63.6°C (rough estimate)
Dichte
1.3840 (rough estimate)
Brechungsindex
1.5790 (estimate)
storage temp. 
2-8°C
L?slichkeit
Practically insoluble in water, freely soluble in acetone and in methylene chloride, soluble in ethanol (96 per cent).
Aggregatzustand
Solid
pka
10.88±0.20(Predicted)
Farbe
Light orange to Yellow to Green
Merck 
14,5564
InChIKey
GQYIWUVLTXOXAJ-UHFFFAOYSA-N
CAS Datenbank
13010-47-4(CAS DataBase Reference)
IARC
2A (Vol. 26, Sup 7) 1987
EPA chemische Informationen
1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (13010-47-4)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher T
R-S?tze: 45-25
S-S?tze: 53-45
RIDADR  3249
WGK Germany  3
RTECS-Nr. YS4900000
HazardClass  6.1(a)
PackingGroup  II
HS Code  29299090
Giftige Stoffe Daten 13010-47-4(Hazardous Substances Data)
Toxizit?t LD50 in male mice (mg/kg): 51 orally; 56 i.p.; 61 s.c. (Thompson, Larson)
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizit?t oral Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P264, P270, P301+P310, P321, P330,P405, P501
H350 Kann Krebs verursachen. Karzinogenit?t Kategorie 1A Achtung GHS hazard pictogramssrc="/GHS08.jpg" width="20" height="20" />
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

1-(2-Chlorethyl)-3-cyclohexyl-1-nitrosoharnstoff Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R45:Kann Krebs erzeugen.
R25:Giftig beim Verschlucken.

S-S?tze Betriebsanweisung:

S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).

Chemische Eigenschaften

Lomustine is a pale yellow powder.

Verwenden

CCNU is an oral anticancer drug that was approved by the U.S. Food and Drug Administration in 1976 for marketing, as lomustine (FDA 2009a). CCNU is used alone or in combination with other antineoplastic agents, including procarbazine and vincristine, etoposide and prednimustine, and other combinations (IARC 1981, HSDB 2009). It is used primarily in the treatment of Hodgkin’s disease and brain tumors, but it has also been used to treat other cancer, includ-ing lung cancer, non-Hodgkin’s lymphoma, malignant melanoma, breast cancer, kidney cancer, and cancer of the gastrointestinal tract (MedlinePlus 2009). It has also been applied to the skin to treat mycosis fungoides and psoriasis.

Definition

ChEBI: An N-nitrosourea that is urea in which one of the nitrogens is substituted by a 2-chloroethyl group and by a nitroso group, while the other nitrogen is substituted by a cyclohexyl group. An alkylating antineoplastic agent, it is used in he treatment of brain tumours, lung cancer, malignant melanoma and other solid tumours.

Allgemeine Beschreibung

Lomustine is available in 10-, 40-, and 100-mg capsules fororal administration in the treatment of primary and metastaticbrain cancers and Hodgkin’s lymphoma. This lipophilicagent is well absorbed, widely distributed, and crosses theblood-brain barrier. Lomustine undergoes extensive hepaticmetabolism, which is mediated by CYP3A4 to give severalhydroxylated metabolites, which arise as a result of oxidationof the cyclohexyl ring. Several of these are more activethan the parent compound. Denitrosation and dechlorinationhave also been demonstrated to occur for lomustine as well.The intact drug was not found in plasma when the agent wasadministered orally. Elimination occurs primarily in theurine with an elimination half-life of 16 to 72 hours.Myelosuppression is dose limiting and presents in a mannersimilar to that seen with carmustine. Other toxicities includenausea, vomiting, anorexia, impotence, sterility, amenorrhea,and infertility. Pulmonary and renal toxicity are rarelyseen during standard-dose therapy but increase during highdosetherapy.

Mechanism of action

Like other nitrosoureas, lomustine acts as a DNA-alkylating agent, and it also inhibits various key enzymatic reactions by carbamoylating proteins.

Sicherheitsprofil

Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Poison by ingestion, intraperitoneal, subcutaneous, intravenous, and possibly other routes. Human systemic effects by ingestion: anorexia, nausea or vomiting, leukopenia (decrease in the white blood cell count), and thrombocytopenia (decrease in the number of blood platelets). Experimental teratogenic and reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of Cland NOx. See also NNITROSO COMPOUNDS.

m?gliche Exposition

A potential danger to those involved in the manufacture, administration or consumption of this antineoplastic (anti-cancer) agent

Carcinogenicity

1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

Versand/Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials

Waste disposal

It is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.

1-(2-Chlorethyl)-3-cyclohexyl-1-nitrosoharnstoff Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


1-(2-Chlorethyl)-3-cyclohexyl-1-nitrosoharnstoff Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 351)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5889 58
Shaanxi TNJONE Pharmaceutical Co., Ltd
+8618092446649
sarah@tnjone.com China 1143 58
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3009 60
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3619 58
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
sales@sdzschem.com China 2930 58
Xiamen AmoyChem Co., Ltd
+86-86-5926051114 +8618959220845
sales@amoychem.com China 6383 58
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22963 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63687 58

13010-47-4(1-(2-Chlorethyl)-3-cyclohexyl-1-nitrosoharnstoff)Verwandte Suche:


  • (chloro-2-ethyl)-1-cyclohexyl-3-nitrosourea
  • (cloro-2-etil)-1-cicloesil-3-nitrosourea
  • 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosoure
  • 1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-ure
  • belustine
  • nci-c04740
  • nsc79037
  • nsc-79037
  • rb1509
  • sri2200
  • cecenu
  • ceenu
  • chloroethylcyclohexylnitrosourea
  • cinu
  • cyclohexylchloroethylnitrosourea
  • icig1109
  • n-(2-chloroethyl)-n’-cyclohexyl-n-nitroso-ure
  • 1-(2-CHLOROETHYL)-3-CYCLOHEXYL-1-NITROSOUREA
  • N-(2-CHLOROETHYL)-N'-CYCLOHEXYL-N-NITROSOUREA
  • Lomustin
  • 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea - Lomustine
  • Urea, N-(2-chloroethyl)-N'-cyclohexyl-N-nitroso-
  • LOMUSTINE(CCNU)
  • 3-(2-chloroethyl)-1-cyclohexyl-3-nitrosourea
  • LoMustine(CeeNU)
  • Lomustine, >=98%
  • LOMUSTINE
  • CCNU
  • Lomustine :LOMUSTINE
  • Lomustine CRS
  • Lomustine>
  • Lomustine USP/EP/BP
  • Lomustine (1369419)
  • 1-(2-chloroethyl) 3-cyclo Hexyl nitroso urea
  • 13010-47-4
  • C9H16ClN3O2
  • Other APIs
  • API
  • CEENU
  • Intermediates & Fine Chemicals
  • Nitric Oxide Reagents
  • Pharmaceuticals
  • Pharmaceutical
  • 13010-47-4
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