R22:Gesundheitssch?dlich beim Verschlucken. R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren. S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Yellow Solid
Verwenden
Clozapine N-oxide has been used:
for the activation of human M4 muscarinic (hM4Di) in primary motor cortex
for inducing in vivo chemogenetic manipulation and impairing locomotor activity in Th-cre transgenic mice
in behavioral testing in mice and for stimulating (HEK293) cells
Allgemeine Beschreibung
Clozapine N-oxide (CNO), inactive from of clozapine drug, activates G-protein-coupled receptors (GPCRs). CNO serves as a synthetic ligand for engineered human muscarinic receptor. It elicits clozapine-like effects upon metabolic conversion. Clozapine conversion to CNO favors its passage through blood-brain barrier.
CLOZAPINE N-OXIDE Upstream-Materialien And Downstream Produkte
Clozapine N-OxideQ: What is
Clozapine N-Oxide Q: What is the CAS Number of
Clozapine N-Oxide Q: What is the storage condition of
Clozapine N-Oxide Q: What are the applications of
Clozapine N-Oxide