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U0126

U0126 Struktur
109511-58-2
CAS-Nr.
109511-58-2
Englisch Name:
U0126
Synonyma:
U0126;UO 126;CS-1122;U0126 >99%;U0126, >=98%;U0126;U 0126;U0126 (Uo126);U 0126 - U 126;1,4-DIAMINO-2,3-DICYANO-1;Bis[amino(o-aminophenylthio)methylene]succinonitrile
CBNumber:
CB4758734
Summenformel:
C18H16N6S2
Molgewicht:
380.49
MOL-Datei:
109511-58-2.mol

U0126 Eigenschaften

Schmelzpunkt:
approximate 154℃(dec.)
Siedepunkt:
565.1±50.0 °C(Predicted)
Dichte
1.44
RTECS-Nr.
EJ9710000
storage temp. 
Desiccate at +4°C
L?slichkeit
Soluble in DMSO (up to 200 mg/ml).
Aggregatzustand
White solid
pka
2.11±0.10(Predicted)
Farbe
White
Wasserl?slichkeit
Soluble in DMSO. Poorly soluble in ethanol and water
Stabilit?t:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
HS Code  2930909899
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P304+P340 BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P405 Unter Verschluss aufbewahren.

U0126 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

U-0126 is a MEK inhibitor with IC50 values of 72 nM and 58 nM for MEK1 and MEK2, respectively. It is noncompetitive with respect adenosine triphosphate (ATP) and its phosphorylation target ERK and it shows little to no inhibition against a number of other kinases including PKC, Ab1, Raf, MEKK, ERK, JNK, MKK-3, MKK-4, MKK-6, Cdk2, and Cdk4. However, U-0126 does phosphorylate and activate AMP-activated protein kinase (AMPK) in a dose-dependent manner (EC50 = 15 μM in HEK293 cells). It increases the ratios of ADP to ATP and AMP to ATP and increases phosphorylation of the AMPK target acetyl-CoA carboxylase (ACC).

Verwenden

U0126 is a MEK inhibitor.

Definition

ChEBI: A dinitrile that is succinonitrile in which the methylene hydrogens at positions 2 and 3 are substituted by (2-aminophenyl)sulfanyl]methylidene groups. A potent and selective non-competitive inhibitor of MAP kinase kinase.

Allgemeine Beschreibung

A potent and specific inhibitor of MEK1 (IC50 = 72 nM) and MEK2 (IC50 = 58 nM). The inhibition is noncompetitive with respect to MEK substrates, ATP and ERK. Has very little effect on other kinases, such as Abl, Cdk2, Cdk4, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, PKC, and Raf. Shown to block doxazosin-induced osteoblastic differentiation. U0126 also acts as an immunosuppressant by effectively blocking IL-2 synthesis and T cell proliferation without affecting the long-term outcomes of either T cell activation or tolerance. Noncompetitive with respect to ATP. Also available in InSolution format (Cat. No. 662009.

Biologische Aktivit?t

Potent and selective non-competitive inhibitor of MAP kinase kinase. Inhibits MEK-1 and MEK-2 (IC 50 values of 0.07 and 0.06 μ M respectively) with little or no effect on the activities of PKC, Abl, Raf, MEKK, ERK, JNK, MKK-3, MKK-4/SEK, MKK-6, Cdk2 or Cdk4. Centrally active following systemic administration in vivo . Also available as part of the MAPK Cascade Inhibitor Tocriset™ and MAPK Inhibitor Tocriset™ .

U0126 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


U0126 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 115)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29791 60
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
Zhengzhou Alfa Chemical Co.,Ltd
+8618530059196
sale04@alfachem.cn China 11818 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Career Henan Chemica Co
+86-0371-86658258 +8613203830695
laboratory@coreychem.com China 30239 58
Shanghai UCHEM Inc.
+862156762820 +86-13564624040
sales@myuchem.com China 7629 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471
sales@sarms4muscle.com China 10473 58
InvivoChem
+1-708-310-1919 +1-13798911105
sales@invivochem.cn United States 6391 58
Henan Aochuang Chemical Co.,Ltd.
+86-0371-63689365 +8618638391208
sales@aochuangchem.com China 9245 58
ShenZhen Trendseen Biological Technology Co.,Ltd.
13417589054
trendseenbio@gmail.com China 11681 58

109511-58-2()Verwandte Suche:


  • U0126
  • 1,4-DIAMINO-2,3-DICYANO-1,4-BIS(2-AMINOPHENYLTHIO)BUTADIENE
  • 1,4-DIAMINO-2,3-DICYANO-1,4-BIS(2-AMINOPHYNYLTIO)BUTADIENE
  • 1,4-DIAMINO-2,3-DICYANO-1,4-BIS(O-AMINOPHENYLMERCAPTO)BUTADIENE
  • 1,4-DIAMINO-2,3-DICYANO-1
  • UO 126
  • U0126 >99%
  • 2,3-Bis[amino[(2-aminophenyl)thio]methylene]butanedinitrile
  • Bis[amino(o-aminophenylthio)methylene]succinonitrile
  • U0126, >=98%
  • (2Z,3Z)-2,3-bis(amino((2-aminophenyl)thio)methylene)succinonitrile
  • (2Z,3Z)-bis{amino[(2-aminophenyl)sulfanyl]methylidene}butanedinitrile
  • Butanedinitrile,2,3-bis[aMino[(2-aMinophenyl)thio]Methylene]-
  • U0126 (Uo126)
  • U 0126 - U 126
  • CS-1122
  • U0126;U 0126
  • (2Z,3Z)-2,3-bis(amino((2-aminophenyl)thio)methylene)succinonitrile/U0126
  • 2,3-Bis(amino((2-aminophenyl)thio)methylene)succinonitrile
  • 109511-58-2
  • 109522-58-2
  • C18H16N6S2
  • Signalling
  • Protein Kinase
  • Inhibitor
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