Sivelestat sodium Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Sivelestat is an acyl enzyme inhibitor of neutrophil elastase, developed as an injectable formulation for the treatment of acute lung injury associated with systemic inflammatory response syndrome. A neutrophil predominant inflammation associated with excessive release of human neutrophil elastase (HNE) from azurophilic granules is capable of damaging both the lung parenchymal cells and the extracellular matrix allowing an alveolar capillary barrier disruption. Sivelestat is a sulfonanilide-containing pivaloyloxy benzene derivative prepared in a three step synthesis. This agent acts as a reversible and selective inhibitor of HNE with an lG.0 value of 0.044 PM. Sivelestat has exhibited potent protective effects against various causes of lung injuries in animal models. In an acid-induced acute lung injury model in conscious hamster, administration of sivelestat for 48 h following HCI instillation, dose-dependently reduced mortality and significantly improved the protein levels in bronchoalveolar lavage fluids and pulmonary artery pressure. In a similar study, the agent inhibited the endotoxin-induced acute lung dysfunctions (marked elevation of pulmonary vascular permeability, leukocyte migration, hemorrhage and parenchymal injury) in different animal species. Moreover, in a cardiopulmonary bypass model in dog, sivelestat ameliorated the respiratory index and interstitial-intra-alveolar edema. Sivelestat has a relatively poor bioavailability, due to an extensive first-pass metabolism and is easily hydrolyzed in vitro to an inactive metabolite. In two animal species, the half-life time was approximately 5-7 min. Clinical trials have shown that treatment with the agent improves respiratory function and facilitates early removal of patients from mechanical ventilation. However, in the last clinical study, conducted by Eli Lilly in patients with acute lung injury, no difference in mortality and safety was seen between sivelestat and placebo.

Verwenden

Treatment of acute lung injury; acute respiratory distress syndrome (elastase inhibitor).

Sivelestat sodium Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Sivelestat sodium Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
airuikechemical co., ltd.	+undefined86-15315557071	sales02@sdzhonghuimaterial.com	China	983	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32070	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	China	52849	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24727	58
Chemtour Biotech Co., Ltd	+8617327281506	market@chemtour.com	China	1460	58
PT CHEM GROUP LIMITED		peter68@ptchemgroup.com	China	35425	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	49979	58

201677-61-4()Verwandte Suche:

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• SIVELESTAT SODIUM HYDRATE
• SIVELESTAT SODIUM TETRAHYDRATE
• n-[2-[[[4-(2,2-dimethyl-1-oxopropoxy)phenyl]sulfonyl]amino]benzoyl]-(s)-glycine monosodium salt tetrahydrate
• Sivelestat sodium
• N-[2-[[[4-(2,2-dimethyl-1-oxopropoxy)phenyl]sulfonyl]amino]benzoyl]-Glycine monosodium salt tetrahydrate
• Sivelestat(anhydrous)
• Glycine, N-[2-[[[4-(2,2-diMethyl-1-oxopropoxy)phenyl]sulfonyl]aMino]benzoyl]-, MonosodiuM salt, tetrahydrate
• sodium,2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetate,tetrahydrate
• Sivelestat sodium Impurity A
• EI546 sodium tetrahydrate
• LY544349 sodium tetrahydrate
• ONO5046 sodium tetrahydrate
• LY 544349;ONO-5046;LY-544349;LY544349
• Sivelestat sodium hydrate (ONO-5046 sodium hydrate)
• Propanoic acid, 2,2-dimethyl-, 4-[[[2-[[(carboxymethyl)amino]carbonyl]phenyl]amino]sulfonyl]phenyl ester, sodium salt, hydrate (1:1:4)
• Elaspol
• Sodium 2-(2-(4-(pivaloyloxy)phenylsulfonamido)benzamido)acetate tetrahydrate
• Ono-EI-600 sodium tetrahydrate
• N-[2-[[[4-(2,2-dimethyl-1-oxopropoxy) phenyl]sulfonyl]amino]benzoyl]-(s)-glycine monosodium salt tetra hydrate
• 201677-61-4
• C20H21N2O7SNa4H2O
• C20H21N2NaO7S
• C20H21N2NaO7S4H2O
• C20H29N2NaO11S