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Sobuzoxane

Sobuzoxane Struktur
98631-95-9
CAS-Nr.
98631-95-9
Englisch Name:
Sobuzoxane
Synonyma:
e)(ester);Sobuzoxane;Perazoline;Sobuzoxane/MST 16;methylpropyl)ester;1,2-bis(4-isobutoxycarbonyloxymethyl-3,5-dioxo-piperazin-1-yl)ethane;4,4’-ethylenebis(1-(hydroxymethyl)-2,6-piperazinedione)bis(isobutylcarbonat;1,2-ethanediylbis((2,6-dioxo-4,1-piperazinediyl)methylene)bis(2-carbonicaci;4,4'-Ethylenebis(2,6-dioxopiperazine-1-methanol)bis(2-methylpropoxyformate);MST-16, 4,4μ-(1,2-Ethanediyl)bis(1-isobutoxycarbonyloxmethyl-2,6-piperazinedione)
CBNumber:
CB4498395
Summenformel:
C22H34N4O10
Molgewicht:
514.53
MOL-Datei:
98631-95-9.mol

Sobuzoxane Eigenschaften

Schmelzpunkt:
128-130°; mp 132-133° (Cai, 1989)
Siedepunkt:
664.9±55.0 °C(Predicted)
Dichte
1.272±0.06 g/cm3(Predicted)
L?slichkeit
DMSO: 19 mg/mL
pka
2.75±0.20(Predicted)
Aggregatzustand
solid

Sicherheit

WGK Germany  2
RTECS-Nr. FG1582500
Toxizit?t LD50 in male, female mice, rats (mg/kg): 807, 960, 877, 567 i.p.; 400, 673, 3025, 2821 s.c.; >5 g/kg orally in all species (Tokiwa)

Sobuzoxane Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Sobuzoxane, a novel bis(2,6-dioxopiperazine) derivative, was introduced in Japan for the treatment of malignant lymphoma and adult T-cell IeukemiaQmphoma (ATLL), which is resistant to chemotherapy and has a poor prognosis. Sobuzoxane exhibits 8 broad spectrum of antitumor activity. It is a noncleavable complexstabilizing topoisomerase II inhibitor and exerts its function via interfering with the catalytic activity of the enzyme to result in an irreversible inhibition of cell division by blockade of chromosome condensation and segregation. Due to Its unique mode of cytocidai activity, it has no cross resistance with many currently available anticancer agents. Sobuzoxane is reported to significantly inhibit growth of human colon, lung, gastric, and breast cancers and is in clinical trials for these indications.

Verwenden

Sobuzoxane is an inhibitor of DNA topoisomerase II which induces apoptosis.

Sobuzoxane Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Sobuzoxane Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 14)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
CONIER CHEM AND PHARMA LIMITED 		+8618523575427
 sales@conier.com China 49374 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 52924 58
LGM Pharma 1-(800)-881-8210
inquiries@lgmpharma.com United States 2123 70
Heterochem 027-88041443 13072715837
 sales@hetero-chem.com China 696 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581
 sales@chemhifuture.com China 4988 58
United States Biological --
 sales@advtechind.com United States 6075 58

98631-95-9()Verwandte Suche:

  • 1,2-bis(4-isobutoxycarbonyloxymethyl-3,5-dioxo-piperazin-1-yl)ethane
  • 1,2-ethanediylbis((2,6-dioxo-4,1-piperazinediyl)methylene)bis(2-carbonicaci
  • 4,4’-ethylenebis(1-(hydroxymethyl)-2,6-piperazinedione)bis(isobutylcarbonat
  • e)(ester)
  • methylpropyl)ester
  • MST-16, 4,4μ-(1,2-Ethanediyl)bis(1-isobutoxycarbonyloxmethyl-2,6-piperazinedione)
  • 4,4'-Ethylenebis(2,6-dioxopiperazine-1-methanol)bis(2-methylpropoxyformate)
  • Perazoline
  • Sobuzoxane
  • [4-[2-[4-(2-METHYLPROPOXYCARBONYLOXYMETHYL)-3,5-DIOXOPIPERAZIN-1-YL]ETHYL]-2,6-DIOXOPIPERAZIN-1-YL]METHYL 2-METHYLPROPYL CARBONATE
  • Carbonic acid, C,C'-[1,2-ethanediylbis[(2,6-dioxo-4,1-piperazinediyl)methylene]] C,C'-bis(2-methylpropyl) ester
  • Sobuzoxane/MST 16
  • 98631-95-9
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