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MERBARONE

MERBARONE Struktur
97534-21-9
CAS-Nr.
97534-21-9
Englisch Name:
MERBARONE
Synonyma:
RLBN1001;RLBN-1001;MERBARONE;NSC-336628;Merbarone - CAS 97534-21-9 - Calbiochem;5-(N-PHENYLCARBAMOYL)-2-THIOBARBITURIC ACID;5-(N-PHENYLCARBOXAMIDO)-2-THIOBARBITURIC ACID;5-(N-Phenylcarbamoyl)-2-thiobarbituric acid, NSC-336628;hexahydro-4,6-dioxo-n-phenyl-2-thioxo-5-pyrimidinecarboxamid;4,6-Dioxo-N-phenyl-2-thioxohexahydropyrimidine-5-carboxamide
CBNumber:
CB4494665
Summenformel:
C11H9N3O3S
Molgewicht:
263.27
MOL-Datei:
97534-21-9.mol

MERBARONE Eigenschaften

Dichte
1.51±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
L?slichkeit
DMSO: >5mg/mL
Aggregatzustand
solid
pka
-2.16±0.20(Predicted)
Farbe
Pink to purple

Sicherheit

WGK Germany  3
RTECS-Nr. UV7714625

MERBARONE Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Merbarone has been used to study its effect on the occurrence of DNA lesions.

Allgemeine Beschreibung

A cell-permeable anticancer drug that inhibits the catalytic activity of topoisomerase II (topo II) without damaging DNA or stabilizing DNA-topo II cleavable complexes (IC50 = 20 μM for purified mammalian topo II versus IC50 = ~ 200 μM for topo I). Also induces apoptosis in human leukemic CEM cells through a caspase-3-like protease-dependent mechanism.

Biochem/physiol Actions

Cell permeable: yes

MERBARONE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

MERBARONE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 41)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
LGM Pharma 1-(800)-881-8210
inquiries@lgmpharma.com United States 2123 70
Sigma-Aldrich 021-61415566 800-8193336
 orderCN@merckgroup.com China 51456 80
Jinan Sanyuan Chemical Co. LTD 0531-58585914 13335164090
 1660423085@qq.com China 411 58
Chunchuang (Wuhan) Technology Co., Ltd 15342225168
 yutianchun2007@126.com China 10003 58
Shanghai Naiys Biological Technology Co., Ltd 18321139117
 316441092@qq.con China 3010 58
Zhengzhou convergence chemical co., LTD 0371-0371-55153829 18003835034
 2853979819@qq.com China 9732 58
Bide Pharmatech Ltd. 400-1647117 13681763483
 product02@bidepharm.com China 62075 58
Changzhou Bojia Biomedical Technology Co., Ltd. 2122619822
 czbjpharma@126.com China 18478 58
TargetMol Chemicals Inc. 4008200310
 marketing@tsbiochem.com China 24644 58
  • 5-(N-PHENYLCARBAMOYL)-2-THIOBARBITURIC ACID
  • 5-(N-PHENYLCARBOXAMIDO)-2-THIOBARBITURIC ACID
  • NSC-336628
  • hexahydro-4,6-dioxo-n-phenyl-2-thioxo-5-pyrimidinecarboxamid
  • 5-(N-Phenylcarbamoyl)-2-thiobarbituric acid, NSC-336628
  • MERBARONE
  • 4,6-dioxo-N-phenyl-2-sulfanylidene-1,3-diazinane-5-carboxamide
  • Merbarone - CAS 97534-21-9 - Calbiochem
  • 5-Pyrimidinecarboxamide, hexahydro-4,6-dioxo-N-phenyl-2-thioxo-
  • RLBN1001
  • RLBN-1001
  • 4,6-Dioxo-N-phenyl-2-thioxohexahydropyrimidine-5-carboxamide , Merbarone
  • 4,6-Dioxo-N-phenyl-2-thioxohexahydropyrimidine-5-carboxamide
  • 97534-21-9
  • Reagents
  • Tools for Gene Regulation Research
  • Gene Regulation and Expression
  • Cell Biology
  • Cell Signaling and Neuroscience
  • BioChemical
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