(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosin Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
S-
Adenosyl-
L-
homocysteine (SAH) is an amino acid derivative and an intermediate, by-
product, or modulator of several metabolic pathways, including the activated methyl cycle and cysteine biosynthesis. It is also a product of S-
adenosyl-
methionine (SAM)-
dependent methylation of biological molecules, including DNA, RNA, and histones and other proteins. SAH is a risk factor for many diseases, including cancer and neurodegenerative diseases. In addition, inhibitors that block its hydrolysis are being developed as anti-
viral, anti-
parasitic, anti-
arthritic and immunosuppressive agents.
Chemische Eigenschaften
Pale Beige Solid
Verwenden
A novel biomarker for predicting susceptibility of a subject to a mental or neurodegenerative disorder.
Definition
ChEBI: The S-adenosyl derivative of L-homocysteine.
l?uterung methode
It has been recrystallised several times from aqueous EtOH or H2O to give small prisms and has max 260nm in H2O. The picrate has m 170o(dec) from H2O. [Baddiley & Jameison J Chem Soc 1085 1955, de la Haba & Cantoni J Biol Chem 234 603 1959, Borchardt et al. J Org Chem 41 565 1976, NMR: Follmann et al. Eur J Biochem 47 187 1974, Beilstein 26 III/IV 3676.]
(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
