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Trihexyphenidylhydrochlorid

Benzhexol hydrochloride Struktur
52-49-3
CAS-Nr.
52-49-3
Bezeichnung:
Trihexyphenidylhydrochlorid
Englisch Name:
Benzhexol hydrochloride
Synonyma:
tremin;win511;Trihexy;Sedrina;Broflex;peragit;pipanol;Aparkane;Antitrem;Parkidyl
CBNumber:
CB4447818
Summenformel:
C20H31NO.ClH
Molgewicht:
337.93
MOL-Datei:
52-49-3.mol

Trihexyphenidylhydrochlorid Eigenschaften

Schmelzpunkt:
Free base, mp 114.3-115.0°
Dichte
0.9801 (rough estimate)
Brechungsindex
1.5790 (estimate)
storage temp. 
Inert atmosphere,Room Temperature
L?slichkeit
H2O: soluble
Aggregatzustand
solid
Farbe
white
Wasserl?slichkeit
670.9ug/L(22.5 ºC)
Merck 
14,9695
Stabilit?t:
Stable at RT, Stable At Rt
InChI
InChI=1S/C20H31NO.ClH/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21;/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2;1H
InChIKey
QDWJJTJNXAKQKD-UHFFFAOYSA-N
SMILES
C(O)(CCN1CCCCC1)(C1CCCCC1)C1C=CC=CC=1.Cl
CAS Datenbank
52-49-3(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 22
S-S?tze: 36
RIDADR  3249
WGK Germany  3
RTECS-Nr. TN2625000
HazardClass  6.1(b)
PackingGroup  III
HS Code  2933399090
Toxizit?t TDLo orl-wmn: 800 mg/kg:BAH BJPYAJ 145,300,84
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Trihexyphenidylhydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R22:Gesundheitssch?dlich beim Verschlucken.

S-S?tze Betriebsanweisung:

S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

Trihexyphenidyl is an antagonist of M1 muscarinic acetylcholine receptors. It binds to rat M1 receptors in cerebral cortex selectively over rat M2 receptors in heart tissue (IC50s = 3.7 and 31 nM, respectively). Trihexyphenidyl inhibits contractions induced by acetylcholine in guinea pig ileum (IC50 = 22 nM). It also inhibits oxotremorine-induced tremors and physostigmine-induced mortality in mice (ED50s = 2 and 3.6 mg/kg, respectively). Trihexyphenidyl (20 mg/kg) improves abnormal movement in a mouse model of L-3,4-dihydroxyphenylalanine (L-DOPA) responsive dystonia (DRD) that expresses mutant tyrosine hydroxylase (TH). Formulations containing trihexyphenidyl have been used in the symptomatic treatment of Parkinson''s disease.

Chemische Eigenschaften

Benzhexol hydrochloride is White Solid

Verwenden

Benzhexol hydrochloride is an anticholinergic tertiary amine that can gain access to the CNS. It is used to treat parkinsonism and the extrapyramidal side effects of anti-psychotic drugs. The drug is a muscarinic anta gonist that qualitatively resembles the belladonna alkaloids in its pharmacological actions and side effects.

Allgemeine Beschreibung

Trihexyphenidylhydrochloride, α-cyclohexyl-α-phenyl-1-piperidinepropanolhydrochloride (Artane, Tremin, Pipanol), introduced in1949, is approximately half as active as atropine as an antispasmodicbut is claimed to have milder side effects, such asmydriasis, drying of secretions, and cardioacceleration. It hasa good margin of safety, although it is about as toxic as atropine.It has found a place in the treatment of parkinsonismand is claimed to provide some measure of relief from themental depression often associated with this condition. It does, however, exhibit some of the side effects typical of theparasympatholytic-type preparation, although adjusting thedose carefully may often eliminate these.

Nebenwirkungen

Common side effects of Benzhexol hydrochloride include drowsiness, dizziness, constipation, flushing, nausea, nervousness, blurred vision or dry mouth. Severe may include: decreased sexual performance, severe stomach/abdominal pain, difficulty/pain in swallowing, difficulty in urinating, chest pain, severe dizziness/fainting, high fever, fast/irregular/slow heartbeat, mental/mood changes (e.g., blurred consciousness, hallucinations, memory problems), pain/swelling/reddening of the eyes, changes in vision (e.g., seeing rainbows around lights at night). Symptoms of very severe allergic reactions in some patients include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, and difficulty breathing. In addition, studies have shown that Benzhexol hydrochloride has minimal side effects in the treatment of salivation in children with cerebral palsy.

Sicherheitsprofil

Poison by ingestion,intraperitoneal, intravenous, and subcutaneous routes. Ananticholinergic agent which causes human psychotropiceffects. Human systemic effects by ingestion: distortedperceptions, eye effects, hallucinations, toxic psychosis.When he

Trihexyphenidylhydrochlorid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Trihexyphenidylhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 274)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
shandong perfect biotechnology co.ltd
+86-53169958659; +8618596095638
sales@sdperfect.com China 294 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177
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SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
sales@sdzschem.com China 2930 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
Shandong chuangyingchemical Co., Ltd.
18853181302
sale@chuangyingchem.com CHINA 5906 58
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sales@chemdad.com China 39894 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58

52-49-3(Trihexyphenidylhydrochlorid)Verwandte Suche:


  • Antitrem
  • Aparkane
  • Broflex
  • Parkidyl
  • Parkinane
  • Parkisan
  • Partigan
  • Sedrina
  • Trihexy
  • Trihexyphenidyl chlorhydrate
  • trihexyphenydyl hydrochloride
  • Triphedinon
  • 1-Cyclohexyl-1-phenyl-3-(1-piperidyl)propan-1-ol hydrochloride
  • parcopane
  • pargitan
  • parkinsan
  • parkopan
  • peragit
  • pipanol
  • romparkin
  • 1-CYCLOHEXYL-1-PHENYL-3-PIPERIDINEPROPANOLHYDROCHLORIDE
  • 1-Phenyl-1-cyclohexyl-3-(N-piperidino)-propanol hydrochloride
  • 1-Piperidinepropanol, a-cyclohexyl-a-phenyl-, hydrochloride (1:1)
  • Triphenidyl hydrochloride
  • Trihexyphenidyl Hydrochloride (200 mg)
  • Trihexyphenidyl Hydrochloride Benzhexol HCL
  • Benzhexol hydrochloride API
  • Benzhexol hydrochloride CP2000,BP98
  • BENZHEXOL HYDROCHLORIDE /ARTANE
  • benzhexolHCl/artane
  • α-Cyclohexyl-α-phenyl-1-piperidinepropanol hydrochloride
  • C20H31NO.ClH
  • TRIHEXYPHENIDYL HCL
  • TRIHEXYPHENIDYL HYDROCHLORIDE
  • TRIHEXYLPHENIDYL HYDROCHLORIDE
  • 1-phenyl-1-cyclohexyl-3-piperidyl-1-propanolhydrochloride
  • 3-(1-piperidyl)-1-cyclohexyl-1-phenyl-1-propanolhydrochloride
  • alpha-cyclohexyl-alpha-phenyl-1-piperidinepropanohydrochloride
  • artanehydrochloride
  • benzhexolchloride
  • cyclodol
  • pacitane
  • paralest
  • tremin
  • triesifenidile
  • triexifenidila
  • tsiklodol
  • win511
  • BENZHEXOL HCL
  • BENZHEXOL HYDROCHLORIDE
  • DL-TRIHEXYPHENIDYL HYDROCHLORIDE
  • ALPHA-CYCLOHEXYL-ALPHA-PHENYL-1-PIPERIDINEPROPANOL HYDROCHLORIDE
  • A-CYCLOHEXYL-A-PHENYL-1-PIPERIDINEPROPANOL, HCL
  • BENHEXOLHYDROCHLORIDE
  • TRIHEXYPHENIDYLHYDROCHLORIDE,USP
  • BENZHEXOL HYDROCHLORIDE /ARTANE/TRIHEXYPHENIDYL HCL
  • 1-Piperidinepropanol, a-cyclohexyl-a-phenyl-, hydrochloride (6CI, 7CI, 8CI, 9CI)
  • 3-(1-Piperidyl)-1-phenyl-1-cyclohexyl-1-propanol hydrochloride
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