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ARANIDIPINE

ARANIDIPINE Struktur
86780-90-7
CAS-Nr.
86780-90-7
Englisch Name:
ARANIDIPINE
Synonyma:
Sapresta;MPC-1304;ARANIDIPINE;Asanidipine;Aranidipine MPC1304;ARANIDIPINE USP/EP/BP;ARANIDIPINE MPC1304;MPC-1304;MPC 1304;Calcium Channel,inhibit,MPC 1304,Inhibitor,MPC-1304,Aranidipine,Ca channels,Ca2+ channels;3-Methyl 5-(2-oxopropyl) 2,6-diMethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;2,6-Dimethyl-4-(2-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylic acid methyl 2-oxopropyl ester
CBNumber:
CB4386708
Summenformel:
C19H20N2O7
Molgewicht:
388.37
MOL-Datei:
86780-90-7.mol

ARANIDIPINE Eigenschaften

Schmelzpunkt:
155°
Siedepunkt:
530.0±50.0 °C(Predicted)
Dichte
1.284±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
L?slichkeit
DMSO : 125 mg/mL (321.86 mM)
Aggregatzustand
Solid
pka
2.56±0.70(Predicted)
Farbe
Light yellow to yellow

Sicherheit

Toxizit?t LD50 in male, female mice, rats (mg/kg): 143, 193, 1982, 1459 orally; LD50 in male, female mice (mg/kg): 7.3, 9.1 i.p. (Nakano)

ARANIDIPINE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Aranidipine was launched in Japan as an antihypertensive agent. Its pharmacological effects are similar to other dihydropyridine derivatives, e.g., nefidipine, however, it is more potent and longer lasting. This is partially due to the fact that its initial metabolite (ketone reduction) is just as effective as the parent compound. Aranidipine exerts its activity by blocking Ca+2 entry during depolarization via L-type voltagegated Ca channels. This causes decreased levels of intracellular Ca which leads to enhanced relaxation of smooth and cardiac muscle. It is a selective α2-adrenoreceptor antagonist which inhibits vasoconstrictive responses. As a dihydropyridine derivative, it can be synthesized via a modified Hantsch synthesis. While sold as a racemate, the (S)-enantiomer is 150 times more active than the (R)- antipode.

ARANIDIPINE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


ARANIDIPINE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 68)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32957 60
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-89586680 +86-18192503167
1026@dideu.com China 7724 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739
info@dycnchem.com China 52849 58
InvivoChem
+1-708-310-1919 +1-13798911105
sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc.

support@targetmol.com United States 38631 58
PT CHEM GROUP LIMITED
+86-85511178; +86-85511178;
peter68@ptchemgroup.com China 35425 58
LGM Pharma 1-(800)-881-8210
inquiries@lgmpharma.com United States 2123 70
Hangzhou Yuhao Chemical Technology Co., Ltd 0571-82693216
info@yuhaochemical.com China 9387 52
Shanghai T&W Pharmaceutical Co., Ltd. +86 21 61551611
China 9891 58

86780-90-7()Verwandte Suche:


  • ARANIDIPINE
  • 2,6-Dimethyl-4-(2-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylic acid methyl 2-oxopropyl ester
  • MPC-1304
  • Sapresta
  • 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-(2-oxopropyl) ester
  • Asanidipine
  • 3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, 3-methyl 5-(2-oxopropyl)ester
  • 3-Methyl 5-(2-oxopropyl) 2,6-diMethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • Aranidipine MPC1304
  • ARANIDIPINE MPC1304;MPC-1304;MPC 1304
  • ARANIDIPINE USP/EP/BP
  • Calcium Channel,inhibit,MPC 1304,Inhibitor,MPC-1304,Aranidipine,Ca channels,Ca2+ channels
  • 86780-90-7
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