2'-Deoxy-L-thymidine
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- CAS-Nr.
- 3424-98-4
- Englisch Name:
- 2'-Deoxy-L-thymidine
- Synonyma:
- Ldt;L-Dt;Sebivo;NV 02B;Epavudine;Aids112549;elbivudine;Aids-112549;L-Deoxythymidine;BETA-L-THYMIDINE
- CBNumber:
- CB4321891
- Summenformel:
- C10H14N2O5
- Molgewicht:
- 242.23
- MOL-Datei:
- 3424-98-4.mol
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2'-Deoxy-L-thymidine Eigenschaften
- Schmelzpunkt:
- 188-190°C
- alpha
- D20 -20.3° (c = 0.192 in water)
- Dichte
- 1.452±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- L?slichkeit
- H2O: soluble10mg/mL (clear solution)
- pka
- 9.55±0.10(Predicted)
- Aggregatzustand
- powder
- Farbe
- white to beige
- Optische Aktivit?t
- [α]/D -15 to -22°, c = 1 in H2O
- InChIKey
- IQFYYKKMVGJFEH-CSMHCCOUSA-N
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher |
Xn |
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R-S?tze: |
22 |
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S-S?tze: |
24/25 |
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WGK Germany |
3 |
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RTECS-Nr. |
UV9048500 |
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HS Code |
29349990 |
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Bildanzeige (GHS) |
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Alarmwort |
Warnung |
Gefahrenhinweise |
Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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Sicherheit |
P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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2'-Deoxy-L-thymidine Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Telbivudine is a b-L-thymidine nucleoside analog launched for the
once-daily oral treatment of chronic hepatitis B virus (HBV) infection. It is
the fourth nucleoside or nucleotide analog to be marketed for this indication. The
previous drugs from this class include lamivudine, a deoxythiacytosine analog,
adefovir, a nucleotide analog, and entecavir, a guanosine analog. Adefovir, entecavir,
and telbivudine are specifically indicated for HBV, whereas lamivudine is indicated for both HBV and HIV infections. Telbivudine is efficiently phosphorylated
by cellular kinases to the active triphosphate derivative, which
inhibits HBV DNA polymerase by competing with the natural substrate, thymidine-
5’-triphosphate.
Chemische Eigenschaften
2'-Deoxy-L-thymidine is White Solid
Definition
ChEBI: A pyrimidine 2'-deoxyribonucleoside that is the L-enantiomer of thymine. A synthetic thymidine nucleoside analogue with activity against HBV DNA polymerase.
2'-Deoxy-L-thymidine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2'-Deoxy-L-thymidine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 315)Lieferanten
3424-98-4()Verwandte Suche:
- 2'-Deoxy-L-thyMidine(Telbivudine)
- Telbivudine(Tyzeka, Sebivo)
- 1-(2-Deoxy-β-L-erythro-pentofuranosyl)-5-Methyl-
- Telbivudine(L-ThyMidine,LDT-600)
- 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)oxolan-2-yl]-5-Methyl-1,2,3,4-tetrahydropyriMidine-2,4-dione
- 2,4(1H,3H)-PyriMidinedione,1-(2-deoxy-b-L-erythro-pentofuranosyl)-5-Methyl-
- Sebivo
- Telbivudine(L-ThyMidine)
- Telbivudine, >=98%
- 1-(2-Deoxy--L-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione
- 1-(2-deoxy--L-erythro-pentofuranosyl)thymine
- Epavudine
- NV 02B
- Aids112549
- Aids-112549
- L-Deoxythymidine
- Ldt
- L-Dt
- Thymine, 1-(2-deoxy-.beta.-L-erythro-pentofuranosyl)-
- BETA-L-THYMIDINE
- 2'-DEOXY-L-THYMIDINE
- L-Thymidine(Telbivudine)
- 1-[(2S,4R,5S)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione
- Β-L-2'-DEOXY-THYMIDINE
- 1-[(2S,4R,5S)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
- 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-β-L-erythro-pentofuranosyl)-5-methyl-
- elbivudine
- 2'-Deoxy-L-thymidine USP/EP/BP
- Telbivudine (Epavudine)
- Telbivudine 13C 15N2
- Inhibitor,Telbivudine,inhibit,HBV,Hepatitis B virus
- 1-[(2S,4R,5S)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
- 2'-Deoxy-L-thymidine
- 3424-98-4
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