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ml390

ml390 Struktur
2029049-79-2
CAS-Nr.
2029049-79-2
Englisch Name:
ml390
Synonyma:
ml390;ML390, 10 mM in DMSO;(R)-N-(3-Oxo-3-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)propyl)-4-(trifluoromethoxy)benzamide;Benzamide, N-[3-oxo-3-[[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]propyl]-4-(trifluoromethoxy)-;ER-HoxA9,Dihydroorotate Dehydrogenase,inhibit,AML,ML 390,differentiatio,U937,DHODH,ML390,myeloid,ML-390,Inhibitor,THP1
CBNumber:
CB43145908
Summenformel:
C21H21F3N2O3
Molgewicht:
406.4
MOL-Datei:
2029049-79-2.mol

ml390 Eigenschaften

Siedepunkt:
599.7±50.0 °C(Predicted)
Dichte
1.31±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
≥40.6 mg/mL in DMSO; insoluble in H2O; ≥17.47 mg/mL in EtOH
Aggregatzustand
solid
pka
13.65±0.46(Predicted)
Farbe
White to off-white

Sicherheit

ml390 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

ML-390 is an inhibitor of dihydroorotate dehydrogenase (DHODH), the enzyme that converts dihydroorotate to orotate during de novo pyrimidine synthesis. In acute myeloid leukemia, leukemic myeloblast development is halted at an immature stage leading to perpetual self-renewal rather than differentiation. ML-390 induces differentiation in the acute myeloid leukemia cell lines U937 (murine) and THP-1 (human) cell lines with an EC50 value of approximately 2 μM.

ml390 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

ml390 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 42)Lieferanten
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  • ml390
  • Benzamide, N-[3-oxo-3-[[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]propyl]-4-(trifluoromethoxy)-
  • ER-HoxA9,Dihydroorotate Dehydrogenase,inhibit,AML,ML 390,differentiatio,U937,DHODH,ML390,myeloid,ML-390,Inhibitor,THP1
  • (R)-N-(3-Oxo-3-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)propyl)-4-(trifluoromethoxy)benzamide
  • ML390, 10 mM in DMSO
  • 2029049-79-2
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