Elafibranor(GFT505)
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- CAS-Nr.
- 923978-27-2
- Englisch Name:
- Elafibranor(GFT505)
- Synonyma:
- CS-2411;SureCN815512;elafibranor E;Elafibranor(GFT505);GFT505(ELAFIBRANOR);GFT505; GFT-505; GFT 505;;Elafibranor (GFT-505, Ph III);ELAFIBRANOR;GF T505;GFT-505;GFT505;Elafibranor(GFT505) ISO 9001：2015 REACH;Propanoic acid, 2-[2,6-dimethyl-4-[(1E)-3-[4-
- CBNumber:
- CB43049684
- Summenformel:
- C22H24O4S
- Molgewicht:
- 384.49
- MOL-Datei:
- 923978-27-2.mol
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Elafibranor(GFT505) Eigenschaften
- Siedepunkt:
- 569.0±50.0 °C(Predicted)
- Dichte
- 1.21±0.1 g/cm3(Predicted)
- storage temp.
- -20°
- L?slichkeit
- Soluble in DMSO (up to at least 25 mg/ml).
- Aggregatzustand
- solid
- pka
- 3.30±0.11(Predicted)
- Farbe
- Pale yellow
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Elafibranor(GFT505) Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Elafibranor is an agonist of the peroxisome proliferator-activated receptors (PPAR) α and δ. It increases HDL secretion and expression of the lipid-related genes
ABCA1,
PLIN2, and
ABHD5 in Caco-2/TC7 cells in a PPARα-dependent manner. Elafibranor (10 mg/kg) decreases levels of plasma triglycerides and total cholesterol while increasing plasma HDL and expression of
Acox1, a PPARα target gene, in the liver of ApoE2-KI wild-type, but not PPARα knockout, mice fed a Western diet. However, PPARα knockout mice exhibit a decrease in plasma total and non-HDL cholesterol levels, indicating PPARδ has a role in these functions. Elafibranor (30 mg/kg) reduces diet-induced macro- and micro-steatosis in a PPARα-deficient mouse model of non-alcoholic steatohepatitis. It also reduces cholesterol and triglyceride accumulation as well as macrovesicular steatosis in the liver of insulin-resistant
db/db mice fed the methionine-choline deficient (MCD) diet. Formulations containing elafibranor are under clinical investigation for the treatment of non-alcoholic steatohepatitis.
Verwenden
GFT-505 is a?dual?PPARα/δ agonist. Studies have shown that GFT-505 improves hepatic and peripheral insulin sensitivity in abdominally obese subjects. It may also be a potential new drug candidate for treating lipid and glucose disorders.
Elafibranor(GFT505) Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Elafibranor(GFT505) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 134)Lieferanten
923978-27-2()Verwandte Suche:
- Elafibranor(GFT505)
- elafibranor E
- Propanoic acid, 2-[2,6-dimethyl-4-[(1E)-3-[4-(methylthio)phenyl]-3-oxo-1-propen-1-yl]phenoxy]-2-methyl-
- 2-[2,6-Dimethyl-4-[(1E)-3-[4-(methylthio)phenyl]-3-oxo-1-propen-1-yl]phenoxy]-2-methylpropanoic acid
- (E)-2-(2,6-dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxoprop-1-en-1-yl)phenoxy)-2-methylpropanoic acid
- SureCN815512
- Elafibranor (GFT-505, Ph III)
- GFT505(ELAFIBRANOR)
- ELAFIBRANOR;GF T505;GFT-505;GFT505
- CS-2411
- GFT505; GFT-505; GFT 505;
- Elafibranor(GFT505) ISO 9001：2015 REACH
- Propanoic acid, 2-[2,6-dimethyl-4-[(1E)-3-[4-
- inhibit,Elafibranor,PPAR,GFT-505,Peroxisome proliferator-activated receptors,GFT 505,Inhibitor
- 923978-27-2
- C22H24O4S
