Brigatinib
|
|
|
- CAS-Nr.
- 1197953-54-0
- Englisch Name:
- Brigatinib
- Synonyma:
- Brig;AP26113 (Brigatinib);140455;atinib;brigatib;Bri atinib;Brigatinib;Bouguer for;Brigatinib API;Bogtinib (AP26113)
- CBNumber:
- CB43041390
- Summenformel:
- C29H39ClN7O2P
- Molgewicht:
- 584.09
- MOL-Datei:
- 1197953-54-0.mol
|
Brigatinib Eigenschaften
- Schmelzpunkt:
- >203°C (dec.)
- Siedepunkt:
- 781.8±70.0 °C(Predicted)
- Dichte
- 1.31±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- L?slichkeit
- Soluble in DMSO (1 mg/ml with warming)
- Aggregatzustand
- solid
- pka
- 8.14±0.42(Predicted)
- Farbe
- White to off-white
- Stabilit?t:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
- InChIKey
- AILRADAXUVEEIR-UHFFFAOYSA-N
- SMILES
- C1(NC2=CC=C(N3CCC(N4CCN(C)CC4)CC3)C=C2OC)=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1
- CAS Datenbank
- 1197953-54-0
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
|
|
| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
|
Brigatinib Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Brigatinib is a small molecule inhibitor of both ALK and EGFR [195]. In preclinical models, “triple-mutant EGFR”-positive cells (activating EGFR mutation/
T790M/C797S) responded to the combination of brigatinib with an anti-EGFR
monoclonal antibody, cetuximab or panitumumab [196]. Single-agent activity of
brigatinib in a phase I/II trial was only 5% [197], possibly compounded by low
plasma concentrations [196], but the addition of an anti-EGFR monoclonal antibody remains to be clinically tested. The preclinical data with brigatinib and
EAI045?in laboratory models with a C797S mutation demonstrate that combination
therapies with an anti-EGFR monoclonal antibody may lead to overcoming resistance to osimertinib.
Trademarks
Alunbrig?
Brigatinib Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Brigatinib Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 307)Lieferanten
- Brigatinib
- Brigatinib, AP26113
- 5-Chloro-N4-[2-(dimethylphosphinyl)phenyl]-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-2,4-pyrimidinediamine
- atinib
- Bri atinib
- 2,4-Pyrimidinediamine, 5-chloro-N4-[2-(dimethylphosphinyl)phenyl]-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-
- Brigatinib USP/EP/BP
- 1197953-54-0 Brigatinib
- Brigatinib - AP 26113 | Alunbrig
- Bogtinib (AP26113)
- 140455
- brigatib
- 5-chloro-N4-(2-(dimethylphosphoryl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine
- AP26113 (Brigatinib)
- Brig
- Bouguer for
- Brigatinib API
- Serpatinib LOXO-292
- 1197953-54-0
- 197953-54-0
- C29H39ClN7O2P
- API
- 1197953-54-0
