1H-Isoindole-1,3(2H)-dione, 5-[5-[[3-(4-broMophenyl)-2-iMino-4-oxo-5-thiazolidinylidene]Methyl]-2-furanyl]-
CAS-Nr.
1420071-30-2
Englisch Name:
1H-Isoindole-1,3(2H)-dione, 5-[5-[[3-(4-broMophenyl)-2-iMino-4-oxo-5-thiazolidinylidene]Methyl]-2-furanyl]-
Synonyma:
CS-1259;BioyMifi;(DR5 ACTIVATOR);Bioymifi (~90%);Bioymifi >=98% (HPLC);Bioymifi, 1420071-30-2;Bioymifi, DR5 Activator;Bioymifi,DR5 Activator, >95%;Bioymifi/High quality/Best price;(Z)-5-(5-[(3-[4-Bromophenyl]-2-imino-4-oxothiazolidin-5-ylidene)methyl]furan-2-yl)isoindoline-1,3-dione
CBNumber:
CB42667852
Summenformel:
C22H12BrN3O4S
Molgewicht:
494.32
MOL-Datei:
1420071-30-2.mol
1H-Isoindole-1,3(2H)-dione, 5-[5-[[3-(4-broMophenyl)-2-iMino-4-oxo-5-thiazolidinylidene]Methyl]-2-furanyl]- Eigenschaften
Dichte
1.75±0.1 g/cm3(Predicted)
storage temp.
2-8°C
L?slichkeit
DMSO: soluble2mg/mL, clear (warmed)
Aggregatzustand
powder
pka
9.62±0.20(Predicted)
Farbe
orange to dark orange red
Sicherheit
Risiko- und Sicherheitserkl?rung
Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher
Xn
R-S?tze:
22
WGK Germany
3
Bildanzeige (GHS)
Alarmwort
Warnung
Gefahrenhinweise
Code
Gefahrenhinweise
Gefahrenklasse
Abteilung
Alarmwort
Symbol
P-Code
H302
Gesundheitssch?dlich bei Verschlucken.
Akute Toxizit?t oral
Kategorie 4
Warnung
src="/GHS07.jpg" width="20" height="20" />
P264, P270, P301+P312, P330, P501
H317
Kann allergische Hautreaktionen verursachen.
Sensibilisierung der Haut
Kategorie 1A
Warnung
src="/GHS07.jpg" width="20" height="20" />
P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
Sicherheit
P280
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
1H-Isoindole-1,3(2H)-dione, 5-[5-[[3-(4-broMophenyl)-2-iMino-4-oxo-5-thiazolidinylidene]Methyl]-2-furanyl]- Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TNF-related apoptosis-inducing ligand (TRAIL or Apo2L), a member of this family, activates apoptosis in a variety of tumor cell lines by signaling through the death receptors, DR4 and DR5. Bioymifi directly activates DR5 (K
d = 1.2 μM; IC
50 = 2 μM), inducing DR5 clustering, which leads to the initiation of FADD/caspase-8-dependent apoptosis in various cancer cells.
1H-Isoindole-1,3(2H)-dione, 5-[5-[[3-(4-broMophenyl)-2-iMino-4-oxo-5-thiazolidinylidene]Methyl]-2-furanyl]- Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
1H-Isoindole-1,3(2H)-dione, 5-[5-[[3-(4-broMophenyl)-2-iMino-4-oxo-5-thiazolidinylidene]Methyl]-2-furanyl]- Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 84)Lieferanten
China 71
United Kingdom 1
United States 12
Global 84
1H-Isoindole-1,3(2H)-dione, 5-[5-[[3-(4-broMophenyl)-2-iMino-4-oxo-5-thiazolidinylidene]Methyl]-2-furanyl]-
BioyMifi
(E)-5-(5-((3-(4-bromophenyl)-2-imino-4-oxothiazolidin-5-ylidene)methyl)furan-2-yl)isoindoline-1,3-dione
Bioymifi 1H-Isoindole-1,3(2H)-dione, 5-[5-[[3-(4-broMophenyl)-2-iMino-4-oxo-5-thiazolidinylidene]Methyl]-2-furanyl]-
Bioymifi, 1420071-30-2
(Z)-5-(5-[(3-[4-Bromophenyl]-2-imino-4-oxothiazolidin-5-ylidene)methyl]furan-2-yl)isoindoline-1,3-dione
5-[5-[[(5Z)-3-(4-Bromophenyl)-2-imino-4-oxo-5-thiazolidinylidene]methyl]-2-furanyl]-1H-isoindole-1,3(2H)-dione
(Z)-5-(5-((3-(4-bromophenyl)-2-imino-4-oxothiazolidin-5-ylidene)methyl)furan-2-yl)isoindoline-1,3-dione (Bioymifi)
Bioymifi,DR5 Activator, >95%
Bioymifi, DR5 Activator
CS-1259
(DR5 ACTIVATOR)
Bioymifi (~90%)
1H-Isoindole-1,3(2H)-dione, 5-[5-[[(5Z)-3-(4-bromophenyl)-2-imino-4-oxo-5-thiazolidinylidene]methyl]-2-furanyl]-
Bioymifi >=98% (HPLC)
Bioymifi/High quality/Best price
1420071-30-2
C22H12BrN3O4S
Inhibitors