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SGI-1027

SGI-1027 Struktur
1020149-73-8
CAS-Nr.
1020149-73-8
Englisch Name:
SGI-1027
Synonyma:
CS-1144;SGI-1027;SGI1027; SGI 1027;SGI-1027 USP/EP/BP;DNA Methyltransferase Inhibitor II;N-[4-[(2-Amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide;N-[4-[(2-amino-6-methylpyrimidin-4-yl)amino]phenyl]-4-(quinolin-4-ylamino)benzamide;Benzamide, N-[4-[(2-amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)-;N-[4-[(2-Amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide SGI-1027;SGI-1027 N-[4-[(2-Amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide
CBNumber:
CB42663344
Summenformel:
C27H23N7O
Molgewicht:
461.52
MOL-Datei:
1020149-73-8.mol

SGI-1027 Eigenschaften

Schmelzpunkt:
>280℃
Dichte
1.387±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
L?slichkeit
Soluble in DMSO (up to 35 mg/ml)
pka
13.31±0.70(Predicted)
Aggregatzustand
powder
Farbe
white to light brown
Stabilit?t:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Sicherheit

SGI-1027 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

SGI-1027 is a quinoline derivative and a potent inhibitor of DNA methyltransferase (DNMT). SGI-1027 can be used as a potential therapeutic agent for the treatment of cancer and other diseases and also as a research tool to investigate the role of DNMTs in epigenetic events.

Biochem/physiol Actions

SGI-1027 is a DNA methyltransferase (DNMT) inhibitor with IC50 values of 6-13 μM for DNMT3B, DNMT3A and DNMT1. SGI-1027 directly inhibits DNMT activity by competing with the cofactor, S-adenosylmethionine (SAM) in the methylation reaction. SGI-1027 treatment of cancer cell lines induced degradation of DNMT1, but not DNMT3A or DNMT3B, and in RKO cells caused re-expression of the silenced tumor supressor genes p16, MLH1 and TIMP3.

SGI-1027 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

ethyl 4-(quinolin-4-ylamino)benzoate 4-(QUINOLIN-4-YLAMINO)-BENZOIC ACID 2,4-Pyrimidinediamine, N4-(4-aminophenyl)-6-methyl- 2,4-Pyrimidinediamine, 6-methyl-N4-(4-nitrophenyl)- Benzamide, N-[4-[(2-amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-nitro- 4-Chlorchinolin 4-Chlor-6-methylpyrimidin-2-ylamin 4-aMino-N-(4-(2-aMino-6-MethylpyriMidin-4-ylaMino)phenyl)benzaMide Benzocain Nitroanilin (p)

Downstream Produkte

SGI-1027 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 93)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32956 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695
 laboratory@coreychem.com China 30236 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
 sales@hzclap.com CHINA 6312 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250
 1026@dideu.com China 22787 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471
 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
Coresyn Pharmatech Co., Ltd. 		+86-571-86626709 +86-18157142896
 cbc@coresyn.com China 9984 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054
 trendseenbio@gmail.com China 11681 58
LEAPCHEM CO., LTD. 		+86-852-30606658
market18@leapchem.com China 43340 58

1020149-73-8()Verwandte Suche:

  • N-[4-[(2-amino-6-methylpyrimidin-4-yl)amino]phenyl]-4-(quinolin-4-ylamino)benzamide
  • SGI-1027
  • N-[4-[(2-Amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide
  • DNA Methyltransferase Inhibitor II
  • Benzamide, N-[4-[(2-amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)-
  • N-[4-[(2-Amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide SGI-1027
  • SGI-1027 N-[4-[(2-Amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide
  • CS-1144
  • SGI1027; SGI 1027
  • SGI-1027 USP/EP/BP
  • 1020149-73-8
  • C27H23N7O
  • Inhibitors
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